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    Irag2 inositol 1,4,5-triphosphate receptor associated 2 [ Mus musculus (house mouse) ]

    Gene ID: 16970, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Irag2provided by MGI
    Official Full Name
    inositol 1,4,5-triphosphate receptor associated 2provided by MGI
    Primary source
    MGI:MGI:108424
    See related
    Ensembl:ENSMUSG00000030263 AllianceGenome:MGI:108424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jaw1; Lrmp; D6Int3; D6Int4; D6Int5; D6Int7; D6Int8
    Summary
    Enables microtubule binding activity. Involved in nucleus organization. Located in endoplasmic reticulum membrane and nuclear envelope. Is expressed in brain; liver; and thymus primordium. Orthologous to human IRAG2 (inositol 1,4,5-triphosphate receptor associated 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 34.9), thymus adult (RPKM 34.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Irag2 in Genome Data Viewer
    Location:
    6 G3; 6 77.34 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (145061357..145120655)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (145111715..145174929)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene branched chain aminotransferase 1, cytosolic Neighboring gene predicted gene, 26666 Neighboring gene STARR-seq mESC enhancer starr_17771 Neighboring gene STARR-positive B cell enhancer ABC_E11339 Neighboring gene STARR-seq mESC enhancer starr_17772 Neighboring gene predicted gene, 38925 Neighboring gene STARR-positive B cell enhancer ABC_E8147 Neighboring gene STARR-seq mESC enhancer starr_17775 Neighboring gene STARR-seq mESC enhancer starr_17776 Neighboring gene STARR-positive B cell enhancer ABC_E2809 Neighboring gene STARR-positive B cell enhancer mm9_chr6:145072197-145072498 Neighboring gene STARR-positive B cell enhancer ABC_E4880 Neighboring gene dynein axonemal intermediate chain 7 Neighboring gene predicted gene 15543 Neighboring gene electron transfer flavoprotein regulatory factor 1 Neighboring gene Kirsten rat sarcoma viral oncogene homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets. Prüschenk S, et al. Int J Mol Sci, 2022 Jun 15. PMID 35743138, Free PMC Article
    2. IRAG2 Interacts with IP(3)-Receptor Types 1, 2, and 3 and Regulates Intracellular Ca(2+) in Murine Pancreatic Acinar Cells. Prüschenk S, et al. Int J Mol Sci, 2021 Dec 14. PMID 34948204, Free PMC Article
    3. Tumor suppressor p53 regulates intestinal type 2 immunity. Chang CY, et al. Nat Commun, 2021 Jun 7. PMID 34099671, Free PMC Article
    4. Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6. Grimm CH, et al. Autoimmunity, 2003 Jun. PMID 14563018
    5. Jaw1, A lymphoid-restricted membrane protein localized to the endoplasmic reticulum. Behrens TW, et al. J Immunol, 1994 Jul 15. PMID 8021504

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets.
      Title: Function of IRAG2 Is Modulated by NO/cGMP in Murine Platelets.
    2. The Lrmp protein is associated with type III IP3 receptor (IP3R3) via its coiled-coil domain in the heterologous expression system.
      Title: Lrmp/Jaw1 is expressed in sweet, bitter, and umami receptor-expressing cells.
    3. Lrmp is a condidate for the type I diabetes susceptility locus Idd6.
      Title: Lrmp and Bcat1 are candidates for the type I diabetes susceptibility locus Idd6.
    4. We hypothesize that the observed decrease in expression of the Lrmp gene in NOD mice may constitute a T1D susceptibility factor in the Idd6 region.
      Title: The Idd6.2 diabetes susceptibility region controls defective expression of the Lrmp gene in nonobese diabetic (NOD) mice.
    5. Lrmp is part of the complex multigenic Pas1 locus, with a functional role for its intragenic polymorphisms and AA changes in lung tumor susceptibility.It may be a tumor suppressor.
      Title: Haplotype sharing suggests that a genomic segment containing six genes accounts for the pulmonary adenoma susceptibility 1 (Pas1) locus activity in mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Not Applicable (2)  1 citation
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleus organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    inositol 1,4,5-triphosphate receptor associated 2
    Names
    lymphoid-restricted membrane protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281980.3 → NP_001268909.2  inositol 1,4,5-triphosphate receptor associated 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121950
      Consensus CDS
      CCDS39704.1

    2. NM_001281981.1 → NP_001268910.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC121950, AK169578
      UniProtKB/TrEMBL
      Q3TL84
      Conserved Domains (1) summary
      pfam05781
      Location:3 → 496
      MRVI1; MRVI1 protein

    3. NM_001361633.2 → NP_001348562.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121950
      UniProtKB/TrEMBL
      Q3TGD7
      Related
      ENSMUSP00000120248.2, ENSMUST00000132948.2
      Conserved Domains (1) summary
      pfam05781
      Location:1 → 443
      MRVI1; MRVI1 protein

    4. NM_001368864.1 → NP_001355793.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Variants 3 and 4 both encode the same isoform (2).
      Source sequence(s)
      AC121950
      UniProtKB/TrEMBL
      Q3TL84
      Conserved Domains (1) summary
      pfam05781
      Location:3 → 496
      MRVI1; MRVI1 protein

    5. NM_001428280.1 → NP_001415209.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC121950

    6. NM_001428281.1 → NP_001415210.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC121950

    7. NM_001428282.1 → NP_001415211.1  inositol 1,4,5-triphosphate receptor associated 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC121950

    8. NM_008511.6 → NP_032537.4  inositol 1,4,5-triphosphate receptor associated 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC121950
      Consensus CDS
      CCDS39704.1
      Related
      ENSMUSP00000032396.7, ENSMUST00000032396.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      145061357..145120655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241568.2 → XP_011239870.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

      See identical proteins and their annotated locations for XP_011239870.1

      UniProtKB/TrEMBL
      G5E880
      Conserved Domains (1) summary
      pfam05781
      Location:10 → 559
      MRVI1; MRVI1 protein

    2. XM_011241569.2 → XP_011239871.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

      See identical proteins and their annotated locations for XP_011239871.1

      UniProtKB/TrEMBL
      G5E880
      Conserved Domains (1) summary
      pfam05781
      Location:10 → 559
      MRVI1; MRVI1 protein

    3. XM_036165896.1 → XP_036021789.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X5

      UniProtKB/TrEMBL
      G5E880
      Conserved Domains (1) summary
      pfam05781
      Location:10 → 442
      MRVI1; MRVI1 protein

    4. XM_011241567.3 → XP_011239869.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X1

      See identical proteins and their annotated locations for XP_011239869.1

      UniProtKB/TrEMBL
      G5E880
      Conserved Domains (1) summary
      pfam05781
      Location:10 → 559
      MRVI1; MRVI1 protein

    5. XM_036165895.1 → XP_036021788.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X3

      UniProtKB/TrEMBL
      G5E880
      Conserved Domains (1) summary
      pfam05781
      Location:10 → 462
      MRVI1; MRVI1 protein

    6. XM_006506924.4 → XP_006506987.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X4

      Conserved Domains (1) summary
      pfam05781
      Location:1 → 443
      MRVI1; MRVI1 protein

    7. XM_011241571.1 → XP_011239873.1  inositol 1,4,5-triphosphate receptor associated 2 isoform X2

      UniProtKB/TrEMBL
      Q3TL84
      Conserved Domains (1) summary
      pfam05781
      Location:30 → 516
      MRVI1; MRVI1 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60664.1 GenPept UniProtKB/Swiss-Prot:Q60664

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