Hapstr1 HUWE1 associated protein modifying stress responses [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hapstr1provided by MGI
Official Full Name: HUWE1 associated protein modifying stress responsesprovided by MGI
Primary source: MGI:MGI:1916303
See related: Ensembl:ENSMUSG00000022507 AllianceGenome:MGI:1916303
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tapr1; Gm19906; 1110017P05Rik; 1810013L24Rik; 3010002C02Rik
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of signal transduction by p53 class mediator and regulation of cellular response to stress. Predicted to be located in cytoplasm and nucleus. Is expressed in retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human HAPSTR1 (HUWE1 associated protein modifying stress responses). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 15.2), bladder adult (RPKM 10.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A1; 16 4.37 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (8647964..8676788)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (8830100..8858924)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.
Title: Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

General gene information

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Markers

C77786 (e-PCR)
- UniSTS:209160

AA792997 (e-PCR)
- UniSTS:160520

R74903 (e-PCR)
- UniSTS:160521

NoName (e-PCR)
- UniSTS:492113

UniSTS:237423 (e-PCR)
- UniSTS:237423

RH125126 (e-PCR)
- UniSTS:161948

C160rf72 (e-PCR)
- UniSTS:519358

AW124177 (e-PCR)
- UniSTS:186054

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction by p53 class mediator	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cellular response to stress	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to stress	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: HUWE1-associated protein modifying stress responses

Names: UPF0472 protein C16orf72 homolog; telomere attrition and p53 response 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.