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    Umps uridine monophosphate synthetase [ Mus musculus (house mouse) ]

    Gene ID: 22247, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Umpsprovided by MGI
    Official Full Name
    uridine monophosphate synthetaseprovided by MGI
    Primary source
    MGI:MGI:1298388
    See related
    Ensembl:ENSMUSG00000022814 AllianceGenome:MGI:1298388
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700095D23Rik
    Summary
    Enables orotate phosphoribosyltransferase activity and orotidine-5'-phosphate decarboxylase activity. Involved in 'de novo' UMP biosynthetic process and UDP biosynthetic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including branchial arch; limb bud; metanephros; pancreas; and surface ectoderm. Human ortholog(s) of this gene implicated in orotic aciduria and purine-pyrimidine metabolic disorder. Orthologous to human UMPS (uridine monophosphate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.6), liver E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Umps in Genome Data Viewer
    Location:
    16 B3; 16 24.26 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (33775152..33787408, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (33954782..33967038, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_40715 Neighboring gene STARR-seq mESC enhancer starr_40716 Neighboring gene STARR-seq mESC enhancer starr_40719 Neighboring gene predicted gene, 34967 Neighboring gene integrin beta 5 Neighboring gene STARR-positive B cell enhancer ABC_E8630 Neighboring gene STARR-seq mESC enhancer starr_40721 Neighboring gene VISTA enhancer mm268 Neighboring gene kalirin, RhoGEF kinase Neighboring gene STARR-seq mESC enhancer starr_40723 Neighboring gene STARR-seq mESC enhancer starr_40724 Neighboring gene predicted gene, 41448 Neighboring gene STARR-seq mESC enhancer starr_40725 Neighboring gene ropporin, rhophilin associated protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma. Kavipurapu PR, et al. J Biol Chem, 1976 Sep 25. PMID 965379
    2. Localization of the adenosine deaminase, transferrin, and UMP synthetase genes on Chinese hamster chromosomes 4 and 6 by in situ hybridization. Qumsiyeh MB, et al. J Hered, 1990 Mar-Apr. PMID 2338490
    3. Expression and sequence analysis of a cDNA encoding the orotidine-5'-monophosphate decarboxylase domain from Ehrlich ascites uridylate synthase. Ohmstede CA, et al. J Biol Chem, 1986 Mar 25. PMID 2419341
    4. Control of de novo pyrimidine biosynthesis in mammalian tissues. Levels and turnover of early intermediates in mouse spleen in vivo. Hisata T, et al. Eur J Biochem, 1980 Mar. PMID 6154574
    5. Pyrimidine Metabolism: Dynamic and Versatile Pathways in Pathogens and Cellular Development. Garavito MF, et al. J Genet Genomics, 2015 May 20. PMID 26059768

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables orotate phosphoribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orotate phosphoribosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables orotate phosphoribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables orotidine-5'-phosphate decarboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables orotidine-5'-phosphate decarboxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables orotidine-5'-phosphate decarboxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' UMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' UMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in UDP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in UMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyrimidine nucleobase biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    uridine 5'-monophosphate synthase
    Names
    UMP synthase
    NP_001335016.1
    NP_033497.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348087.1 → NP_001335016.1  uridine 5'-monophosphate synthase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an in-frame portion of the 5' coding region, and uses a downstream start codon compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC165079, AK035997
      Conserved Domains (1) summary
      pfam00215
      Location:74 → 288
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family

    2. NM_009471.3 → NP_033497.1  uridine 5'-monophosphate synthase isoform 1

      See identical proteins and their annotated locations for NP_033497.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC165079, AK035821, BM219105
      Consensus CDS
      CCDS28136.1
      UniProtKB/Swiss-Prot
      P13439, Q99L26
      UniProtKB/TrEMBL
      Q3TVV7, Q544K9
      Related
      ENSMUSP00000023510.7, ENSMUST00000023510.7
      Conserved Domains (2) summary
      pfam00215
      Location:252 → 466
      OMPdecase; Orotidine 5'-phosphate decarboxylase / HUMPS family
      cl00309
      Location:9 → 204
      PRTases_typeI; Phosphoribosyl transferase (PRT)-type I domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      33775152..33787408 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P13439.3 GenPept UniProtKB/Swiss-Prot:P13439

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