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    Ifitm3 interferon induced transmembrane protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66141, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ifitm3provided by MGI
    Official Full Name
    interferon induced transmembrane protein 3provided by MGI
    Primary source
    MGI:MGI:1913391
    See related
    Ensembl:ENSMUSG00000025492 AllianceGenome:MGI:1913391
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fgls; IP15; Cd225; mil-1; Cdw217; DSPA2b; 1110004C05Rik
    Summary
    Involved in negative regulation of viral entry into host cell and response to virus. Acts upstream of or within defense response to symbiont; negative regulation of cell population proliferation; and receptor-mediated endocytosis. Located in several cellular components, including apical part of cell; cell surface; and endoplasmic reticulum. Is expressed in several structures, including egg cylinder; embryo ectoderm; genitourinary system; gut; and mesenchyme derived from lateral plate. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 350.2), subcutaneous fat pad adult (RPKM 292.7) and 19 other tissues See more
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    Genomic context

    See Ifitm3 in Genome Data Viewer
    Location:
    7 F5; 7 86.25 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140589503..140590657, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141009590..141010744, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7514 Neighboring gene predicted gene, 33504 Neighboring gene STARR-seq mESC enhancer starr_20469 Neighboring gene interferon induced transmembrane protein 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:148234260-148234369 Neighboring gene predicted gene, 39114

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within defense response to virus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral entry into host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral genome replication IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of viral genome replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of viral transcription ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to interferon-alpha IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interferon-alpha ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to interferon-beta IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to interferon-beta ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to type II interferon ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type I interferon-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within type I interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in early endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon-induced transmembrane protein 3
    Names
    dispanin subfamily A member 2b
    fragilis protein
    ifitm-like protein 1
    interferon-inducible protein 15

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025378.2NP_079654.1  interferon-induced transmembrane protein 3

      See identical proteins and their annotated locations for NP_079654.1

      Status: PROVISIONAL

      Source sequence(s)
      AK003407
      Consensus CDS
      CCDS21996.1
      UniProtKB/Swiss-Prot
      Q9CQW9, Q9D8L6
      Related
      ENSMUSP00000026565.7, ENSMUST00000026565.7
      Conserved Domains (1) summary
      pfam04505
      Location:45117
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      140589503..140590657 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)