U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Cd209b CD209b antigen [ Mus musculus (house mouse) ]

    Gene ID: 69165, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd209bprovided by MGI
    Official Full Name
    CD209b antigenprovided by MGI
    Primary source
    MGI:MGI:1916415
    See related
    Ensembl:ENSMUSG00000065987 AllianceGenome:MGI:1916415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OtB7; SIGNR1; mSIGNR1; DC-SIGNR1; 1810030I22Rik
    Summary
    Enables (1->3)-beta-D-glucan binding activity and D-mannose binding activity. Acts upstream of or within several processes, including detection of other organism; phagocytosis, recognition; and positive regulation of tumor necrosis factor production. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in Coronavirus infectious disease (multiple); aspergillosis; dengue disease (multiple); human immunodeficiency virus infectious disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including CD209 (CD209 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 21.2), spleen adult (RPKM 2.2) and 3 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cd209b in Genome Data Viewer
    Location:
    8 A1.1; 8 1.92 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3967655..3976841, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3917655..3926841, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CD209e antigen Neighboring gene STARR-seq mESC enhancer starr_20599 Neighboring gene STARR-seq mESC enhancer starr_20600 Neighboring gene CD209d antigen Neighboring gene STARR-seq mESC enhancer starr_20601 Neighboring gene CD209c antigen Neighboring gene predicted gene, 39122

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (1->3)-beta-D-glucan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables D-mannose binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables D-mannose binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables polysaccharide binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables virus receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD209 antigen-like protein B
    Names
    DC-SIGN-related protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037800.3NP_001032889.3  CD209 antigen-like protein B isoform b

      See identical proteins and their annotated locations for NP_001032889.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AF374471, AF424803, AK138999
      Consensus CDS
      CCDS22076.1
      UniProtKB/Swiss-Prot
      Q8CJ91
      UniProtKB/TrEMBL
      Q3UTX5, Q8CJ85
      Related
      ENSMUSP00000126070.2, ENSMUST00000171635.8
      Conserved Domains (1) summary
      cd03590
      Location:165287
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    2. NM_001287211.1NP_001274140.1  CD209 antigen-like protein B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon in the 5' coding region, and includes an additional in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC121948, AF374471, AF424803, AK138999
      Consensus CDS
      CCDS72089.1
      UniProtKB/Swiss-Prot
      Q8CJ91
      UniProtKB/TrEMBL
      Q3UTX5, Q8CJ85
      Related
      ENSMUSP00000140695.2, ENSMUST00000188386.2
      Conserved Domains (1) summary
      cd03590
      Location:165308
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    3. NM_026972.5NP_081248.4  CD209 antigen-like protein B isoform a

      See identical proteins and their annotated locations for NP_081248.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AF373409, AF424803, AK138999
      Consensus CDS
      CCDS22077.1
      UniProtKB/Swiss-Prot
      Q8BGZ0, Q8BHK7, Q8CJ86, Q8CJ87, Q8CJ88, Q8CJ89, Q8CJ90, Q8CJ91, Q8CJ92, Q8CJ93, Q8CJ94, Q91ZW4, Q91ZX0, Q9D8V4
      UniProtKB/TrEMBL
      Q3UTX5
      Related
      ENSMUSP00000081104.3, ENSMUST00000084086.9
      Conserved Domains (1) summary
      cd03590
      Location:195317
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    RNA

    1. NR_104430.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF424803, AK138999
      Related
      ENSMUST00000111014.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      3967655..3976841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508870.4XP_006508933.1  CD209 antigen-like protein B isoform X1

      Conserved Domains (1) summary
      cl02432
      Location:203286
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_104431.1: Suppressed sequence

      Description
      NR_104431.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.