Incenp inner centromere protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Incenpprovided by MGI
Official Full Name: inner centromere proteinprovided by MGI
Primary source: MGI:MGI:1313288
See related: Ensembl:ENSMUSG00000024660 AllianceGenome:MGI:1313288
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C130081E20; 2700067E22Rik
Summary: Predicted to enable molecular function activator activity. Predicted to be involved in meiotic spindle midzone assembly; metaphase chromosome alignment; and mitotic cytokinesis. Located in several cellular components, including chromocenter; midbody; and synaptonemal complex. Is expressed in brain ventricular layer; cerebral cortex subventricular zone; and heart. Orthologous to human INCENP (inner centromere protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E14 (RPKM 26.8), CNS E11.5 (RPKM 25.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 6.1 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (9849659..9876853, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (9872295..9899489, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

INCENP labels the spermatogonia synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocentres
Title: Dynamic relocalization of the chromosomal passenger complex proteins inner centromere protein (INCENP) and aurora-B kinase during male mouse meiosis.
INCENP recruits Aurora-C (or some other factor(s) recruit INCENP and Aurora-C) to meiotic chromosomes, while Aurora-C may either work alone or cooperate with Aurora-B to regulate chromosome segregation during male meiosis
Title: Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136422 (e-PCR)
- UniSTS:210411

MARC_3953-3954:996679214:1 (e-PCR)
- UniSTS:269294

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular function activator activity	IEA Inferred from Electronic Annotation more info
enables molecular function activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in metaphase chromosome alignment	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle midzone assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle organization	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of attachment of mitotic spindle microtubules to kinetochore	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic sister chromatid separation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in central element	IDA Inferred from Direct Assay more info	PubMed
located_in chromocenter	IDA Inferred from Direct Assay more info	PubMed
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info	PubMed
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral element	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISS Inferred from Sequence or Structural Similarity more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptonemal complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inner centromere protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001369356.1 → NP_001356285.1 inner centromere protein isoform 1

Status: VALIDATED

Source sequence(s)

AC132253

Consensus CDS

CCDS89338.1

UniProtKB/Swiss-Prot

Q7TN28, Q8BGN4, Q8CGI4, Q9WU62

Related

ENSMUSP00000157547.2, ENSMUST00000237439.2

Conserved Domains (3) summary

PTZ00121
Location:513 → 656

PTZ00121; MAEBL; Provisional

pfam03941
Location:795 → 849

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
NM_016692.4 → NP_057901.2 inner centromere protein isoform 2

See identical proteins and their annotated locations for NP_057901.2

Status: VALIDATED

Source sequence(s)

AC132253

Consensus CDS

CCDS37912.1

UniProtKB/Swiss-Prot

Q9WU62

Related

ENSMUSP00000025562.8, ENSMUST00000025562.9

Conserved Domains (4) summary

pfam03941
Location:795 → 846

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam12178
Location:6 → 41

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal

cd16269
Location:588 → 599

GBP_C; coiled coil [structural motif]

cl20817
Location:515 → 619

GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

9849659..9876853 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526708.2 → XP_006526771.2 inner centromere protein isoform X2

Conserved Domains (4) summary

PTZ00121
Location:503 → 659

PTZ00121; MAEBL; Provisional

pfam03941
Location:798 → 852

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam09726
Location:394 → 595

Macoilin; Macoilin family

pfam12178
Location:13 → 48

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_006526710.2 → XP_006526773.2 inner centromere protein isoform X4

Conserved Domains (4) summary

PTZ00121
Location:520 → 625

PTZ00121; MAEBL; Provisional

pfam03941
Location:762 → 816

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam09726
Location:394 → 582

Macoilin; Macoilin family

pfam12178
Location:13 → 48

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_011247154.1 → XP_011245456.1 inner centromere protein isoform X3

Conserved Domains (4) summary

PTZ00121
Location:516 → 663

PTZ00121; MAEBL; Provisional

pfam03941
Location:782 → 836

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam09726
Location:394 → 599

Macoilin; Macoilin family

pfam12178
Location:13 → 48

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal
XM_006526707.2 → XP_006526770.2 inner centromere protein isoform X1

Conserved Domains (4) summary

PTZ00121
Location:520 → 663

PTZ00121; MAEBL; Provisional

pfam03941
Location:802 → 856

INCENP_ARK-bind; Inner centromere protein, ARK binding region

pfam09726
Location:394 → 599

Macoilin; Macoilin family

pfam12178
Location:13 → 48

INCENP_N; Chromosome passenger complex (CPC) protein INCENP N terminal