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    Ints11 integrator complex subunit 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298688, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ints11provided by RGD
    Official Full Name
    integrator complex subunit 11provided by RGD
    Primary source
    RGD:1306841
    See related
    EnsemblRapid:ENSRNOG00000019712 AllianceGenome:RGD:1306841
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    int11; Cpsf3l
    Summary
    Predicted to enable RNA endonuclease activity. Predicted to be involved in snRNA processing. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of integrator complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with motor and language delay, ocular defects, and brain abnormalities. Orthologous to human INTS11 (integrator complex subunit 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 119.4), Lung (RPKM 114.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ints11 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171761370..171779883)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166479134..166497956)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (173318435..173336930)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene dishevelled segment polarity protein 1 Neighboring gene taste 1 receptor member 3 Neighboring gene ceramide-1-phosphate transfer protein Neighboring gene pseudouridine synthase like 1 Neighboring gene ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Neighboring gene sodium channel epithelial 1 delta subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nuclear-localized Asunder regulates cytoplasmic dynein localization via its role in the integrator complex. Jodoin JN, et al. Mol Biol Cell, 2013 Sep. PMID 23904267, Free PMC Article
    2. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Baillat D, et al. Cell, 2005 Oct 21. PMID 16239144
    3. Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability. Bastos-Amador P, et al. J Proteomics, 2012 Jun 27. PMID 22516433
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124975

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in snRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in snRNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of integrator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of integrator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    integrator complex subunit 11
    Names
    CPSF3-like protein
    cleavage and polyadenylation specific factor 3-like
    cleavage and polyadenylation-specific factor 3-like protein
    NP_001029064.2
    XP_006239611.1
    XP_006239612.1
    XP_006239613.1
    XP_006239614.1
    XP_006239615.1
    XP_017448807.1
    XP_063143576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033892.2 → NP_001029064.2  integrator complex subunit 11

      See identical proteins and their annotated locations for NP_001029064.2

      Status: VALIDATED

      Source sequence(s)
      BC105303, JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6B2F1, A0A8L2UK86, A6IUT8
      Related
      ENSRNOP00000095330.1, ENSRNOT00000107036.2
      Conserved Domains (5) summary
      smart01027
      Location:246 → 364
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 445
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 417
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:7 → 205
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:409 → 481
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171761370..171779883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239549.5 → XP_006239611.1  integrator complex subunit 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6B2F1
      Conserved Domains (4) summary
      smart01027
      Location:246 → 364
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 445
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 417
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:7 → 205
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

    2. XM_006239550.5 → XP_006239612.1  integrator complex subunit 11 isoform X2

      UniProtKB/TrEMBL
      A0A8I6B2F1
      Conserved Domains (4) summary
      smart01027
      Location:246 → 364
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 445
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 417
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:7 → 205
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

    3. XM_006239551.4 → XP_006239613.1  integrator complex subunit 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6B2F1
      Conserved Domains (5) summary
      smart01027
      Location:246 → 364
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 445
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:377 → 417
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:7 → 205
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain
      cl02570
      Location:409 → 481
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...

    4. XM_006239553.5 → XP_006239615.1  integrator complex subunit 11 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6F2
      Related
      ENSRNOP00000087757.1, ENSRNOT00000101518.2
      Conserved Domains (4) summary
      smart01027
      Location:198 → 316
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:5 → 397
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:329 → 369
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cl23716
      Location:7 → 157
      metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

    5. XM_006239552.4 → XP_006239614.1  integrator complex subunit 11 isoform X4

      UniProtKB/TrEMBL
      A0A8I6B2F1
      Conserved Domains (4) summary
      smart01027
      Location:216 → 334
      Beta-Casp; Beta-Casp domain
      COG1236
      Location:1 → 415
      YSH1; RNA processing exonuclease, beta-lactamase fold, Cft2 family [Translation, ribosomal structure and biogenesis]
      pfam07521
      Location:347 → 387
      RMMBL; RNA-metabolizing metallo-beta-lactamase
      cd16291
      Location:1 → 175
      INTS11-like_MBL-fold; Integrator complex subunit 11, and related proteins; MBL-fold metallo-hydrolase domain

    6. XM_063287506.1 → XP_063143576.1  integrator complex subunit 11 isoform X6

      UniProtKB/TrEMBL
      A0A8I6B2F1
      Related
      ENSRNOP00000026725.6, ENSRNOT00000026725.6

    7. XM_017593318.3 → XP_017448807.1  integrator complex subunit 11 isoform X7

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3MHC2.1 GenPept UniProtKB/Swiss-Prot:Q3MHC2

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