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    Kif9 kinesin family member 9 [ Mus musculus (house mouse) ]

    Gene ID: 16578, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Kif9provided by MGI
    Official Full Name
    kinesin family member 9provided by MGI
    Primary source
    MGI:MGI:1098237
    See related
    Ensembl:ENSMUSG00000032489 AllianceGenome:MGI:1098237
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including ATP hydrolysis activity; identical protein binding activity; and microtubule binding activity. Involved in regulation of flagellated sperm motility. Located in sperm flagellum. Is expressed in cochlea; hippocampus; lateral ventricle choroid plexus; metanephros; and metencephalon part of 4th ventricle choroid plexus. Orthologous to human KIF9 (kinesin family member 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 35.4) and lung adult (RPKM 1.2) See more
    Orthologs
    human all
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    Genomic context

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    See Kif9 in Genome Data Viewer
    Location:
    9 F2; 9 59.92 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110306062..110354242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110476738..110525174)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch-like 18 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318 Neighboring gene STARR-seq mESC enhancer starr_25264 Neighboring gene SET domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_25267 Neighboring gene neurotrophin receptor associated death domain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum. Miyata H, et al. Exp Anim, 2022 Feb 9. PMID 34526446, Free PMC Article
    2. Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility. Fang C, et al. J Cell Biol, 2024 Nov 4. PMID 39158699,
    3. Testis-enriched kinesin KIF9 is important for progressive motility in mouse spermatozoa. Miyata H, et al. FASEB J, 2020 Apr. PMID 32072696, Free PMC Article
    4. The Ras-like GTPase Gem is involved in cell shape remodelling and interacts with the novel kinesin-like protein KIF9. Piddini E, et al. EMBO J, 2001 Aug 1. PMID 11483511, Free PMC Article
    5. NXF2 is involved in cytoplasmic mRNA dynamics through interactions with motor proteins. Takano K, et al. Nucleic Acids Res, 2007. PMID 17403691, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.
      Title: Distinct roles of Kif6 and Kif9 in mammalian ciliary trafficking and motility.
    2. The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum.
      Title: The motor domain of testis-enriched kinesin KIF9 is essential for its localization in the mouse flagellum.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141389

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in extracellular matrix disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organelle disassembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of podosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in podosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF9
    Names
    kinesin 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163569.2 → NP_001157041.1  kinesin-like protein KIF9 isoform 1

      See identical proteins and their annotated locations for NP_001157041.1

      Status: VALIDATED

      Source sequence(s)
      AC132103
      Consensus CDS
      CCDS52938.1
      UniProtKB/TrEMBL
      Q3V3Y6, Q8C0X6
      Related
      ENSMUSP00000057896.7, ENSMUST00000061155.12
      Conserved Domains (1) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup

    2. NM_001411177.1 → NP_001398106.1  kinesin-like protein KIF9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC132103
      UniProtKB/TrEMBL
      Q3V3Y6, Q8C0X6

    3. NM_001411178.1 → NP_001398107.1  kinesin-like protein KIF9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC132103
      UniProtKB/Swiss-Prot
      E9QMT7, O35070, Q9WV04
      UniProtKB/TrEMBL
      Q3V3Y6

    4. NM_001411179.1 → NP_001398108.1  kinesin-like protein KIF9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC132103
      UniProtKB/TrEMBL
      Q3V3Y6

    5. NM_001411180.1 → NP_001398109.1  kinesin-like protein KIF9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC132103
      UniProtKB/TrEMBL
      Q3V3Y6

    6. NM_010628.4 → NP_034758.2  kinesin-like protein KIF9 isoform 2

      See identical proteins and their annotated locations for NP_034758.2

      Status: VALIDATED

      Source sequence(s)
      AC132103
      Consensus CDS
      CCDS23568.1
      UniProtKB/Swiss-Prot
      E9QMT7, O35070, Q9WV04
      UniProtKB/TrEMBL
      Q3V3Y6
      Related
      ENSMUSP00000082016.6, ENSMUST00000084952.8
      Conserved Domains (2) summary
      cd01375
      Location:6 → 338
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
      pfam00225
      Location:12 → 340
      Kinesin; Kinesin motor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110306062..110354242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511944.3 → XP_006512007.1  kinesin-like protein KIF9 isoform X2

      See identical proteins and their annotated locations for XP_006512007.1

      UniProtKB/TrEMBL
      Q3V3Y6
      Conserved Domains (1) summary
      cd01375
      Location:20 → 352
      KISc_KIF9_like; Kinesin motor domain, KIF9-like subgroup
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV04.2 GenPept UniProtKB/Swiss-Prot:Q9WV04

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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