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    Trim36 tripartite motif-containing 36 [ Mus musculus (house mouse) ]

    Gene ID: 28105, updated on 9-Dec-2024

    Summary

    Official Symbol
    Trim36provided by MGI
    Official Full Name
    tripartite motif-containing 36provided by MGI
    Primary source
    MGI:MGI:106264
    See related
    Ensembl:ENSMUSG00000033949 AllianceGenome:MGI:106264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    haprin; D18Wsu100e
    Summary
    Enables alpha-tubulin binding activity and ubiquitin-protein transferase activity. Involved in regulation of cell cycle. Acts upstream of or within acrosome reaction. Located in acrosomal vesicle. Is expressed in extraembryonic component; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in anencephaly. Orthologous to human TRIM36 (tripartite motif containing 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 82.8), whole brain E14.5 (RPKM 6.2) and 2 other tissues See more
    Orthologs
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    Genomic context

    See Trim36 in Genome Data Viewer
    Location:
    18 C; 18 24.41 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (46298367..46345674, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (46165300..46212607, complement)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A330093E20 gene Neighboring gene STARR-seq mESC enhancer starr_44494 Neighboring gene predicted gene, 26262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:46252362-46252681 Neighboring gene STARR-positive B cell enhancer ABC_E7582 Neighboring gene predicted gene, 52355 Neighboring gene predicted gene, 51427 Neighboring gene predicted gene, 52364 Neighboring gene STARR-positive B cell enhancer ABC_E9977 Neighboring gene STARR-seq mESC enhancer starr_44498 Neighboring gene protein geranylgeranyltransferase type I, beta subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acrosome reaction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within acrosome reaction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within microtubule bundle formation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cytokinesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of microtubule cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of microtubule cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spindle organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase Trim36
    Names
    RING-type E3 ubiquitin transferase TRIM36
    acrosome RBCC protein
    tripartite motif-containing protein 36
    NP_001164326.1
    NP_849203.2
    XP_036017058.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170855.1NP_001164326.1  E3 ubiquitin-protein ligase Trim36 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC124717, BC058106, BM938922, CJ046908, CJ301781
      Consensus CDS
      CCDS50279.1
      UniProtKB/TrEMBL
      E9Q3A0
      Related
      ENSMUSP00000129771.2, ENSMUST00000167364.9
      Conserved Domains (5) summary
      smart00060
      Location:419482
      FN3; Fibronectin type 3 domain
      cd00021
      Location:199237
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:2149
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:504707
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:244368
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_178872.4NP_849203.2  E3 ubiquitin-protein ligase Trim36 isoform 1

      See identical proteins and their annotated locations for NP_849203.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC058106, BM938922, CJ167273, CJ301781
      Consensus CDS
      CCDS29229.1
      UniProtKB/Swiss-Prot
      Q7TNM1, Q80WG7
      Related
      ENSMUSP00000037978.5, ENSMUST00000037011.6
      Conserved Domains (5) summary
      smart00060
      Location:431494
      FN3; Fibronectin type 3 domain
      cd00021
      Location:211249
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam13445
      Location:3361
      zf-RING_UBOX; RING-type zinc-finger
      cd12894
      Location:516719
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cl23765
      Location:256380
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      46298367..46345674 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161165.1XP_036017058.1  E3 ubiquitin-protein ligase Trim36 isoform X1

      Conserved Domains (7) summary
      smart00502
      Location:167291
      BBC; B-Box C-terminal domain
      smart00060
      Location:342405
      FN3; Fibronectin type 3 domain
      cd12894
      Location:427630
      SPRY_PRY_TRIM36; PRY/SPRY domain in tripartite motif-containing protein 36 (TRIM36)
      cd19778
      Location:121165
      Bbox2_TRIM36_C-I; B-box-type 2 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      cd19848
      Location:62116
      Bbox1_TRIM36_C-I; B-box-type 1 zinc finger found in tripartite motif-containing protein 36 (TRIM36) and similar proteins
      pfam18568
      Location:270318
      COS; TRIM C-terminal subgroup One Signature domain
      cl17238
      Location:2236
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain