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    Pter phosphotriesterase related [ Mus musculus (house mouse) ]

    Gene ID: 19212, updated on 21-Dec-2024

    Summary

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    Official Symbol
    Pterprovided by MGI
    Official Full Name
    phosphotriesterase relatedprovided by MGI
    Primary source
    MGI:MGI:107372
    See related
    Ensembl:ENSMUSG00000026730 AllianceGenome:MGI:107372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mpr56-1
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds and zinc ion binding activity. Predicted to be involved in catabolic process and epithelial cell differentiation. Is expressed in liver lobe; urinary system; and ventricular layer. Orthologous to human PTER (phosphotriesterase related). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 33.8), frontal lobe adult (RPKM 10.9) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pter in Genome Data Viewer
    Location:
    2 A1; 2 9.63 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (12928828..13008265)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (12924037..13003454)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5886 Neighboring gene MINDY lysine 48 deubiquitinase 3 Neighboring gene STARR-seq mESC enhancer starr_03692 Neighboring gene STARR-seq mESC enhancer starr_03694 Neighboring gene predicted gene 13321 Neighboring gene STARR-seq mESC enhancer starr_03695 Neighboring gene STARR-seq mESC enhancer starr_03696 Neighboring gene STARR-seq mESC enhancer starr_03697 Neighboring gene STARR-positive B cell enhancer ABC_E4415 Neighboring gene STARR-seq mESC enhancer starr_03698 Neighboring gene predicted gene, 52597 Neighboring gene C1q-like 3 Neighboring gene STARR-seq mESC enhancer starr_03699 Neighboring gene Ras suppressor protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E5887 Neighboring gene STARR-positive B cell enhancer ABC_E1000 Neighboring gene STARR-positive B cell enhancer ABC_E5888 Neighboring gene STARR-seq mESC enhancer starr_03701 Neighboring gene STARR-seq mESC enhancer starr_03702 Neighboring gene predicted gene 13270 Neighboring gene cubilin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mouse kidney- and liver-expressed cDNA having homology with a prokaryotic parathion hydrolase (phosphotriesterase)-encoding gene: abnormal expression in injured and polycystic kidneys. Hou X, et al. Gene, 1996 Feb 12. PMID 8654936
    2. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity. Wei W, et al. Nature, 2024 Sep. PMID 39112712, Free PMC Article
    3. Homology and the evolution of vocal folds in the novel avian voice box. Longtine C, et al. Curr Biol, 2024 Feb 5. PMID 38183987
    4. Recent acquisition of imprinting at the rodent Sfmbt2 locus correlates with insertion of a large block of miRNAs. Wang Q, et al. BMC Genomics, 2011 Apr 21. PMID 21510876, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity.
      Title: PTER is a N-acetyltaurine hydrolase that regulates feeding and obesity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetyltaurine hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of appetite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in taurine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    N-acetyltaurine hydrolase; phosphotriesterase-related protein
    Names
    parathion hydrolase (phosphotriesterase)-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305436.1 → NP_001292365.1  N-acetyltaurine hydrolase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the UTRs and has multiple coding region differences that result in use of a downstream start codon and a frame-shift in the 3' coding region compared to variant 1. It encodes isoform 3, which has a shorter N-terminus and a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AI021584, AK012076, AK075604, AL929209, BM115320, BY241873, BY704600, U28016
      Consensus CDS
      CCDS84471.1
      UniProtKB/TrEMBL
      A2AUR3
      Related
      ENSMUSP00000028063.5, ENSMUST00000028063.7
      Conserved Domains (1) summary
      cl00281
      Location:15 → 257
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. NM_001305437.1 → NP_001292366.1  N-acetyltaurine hydrolase isoform 1

      See identical proteins and their annotated locations for NP_001292366.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK075604, AL929209, BB854955, BB868274, BY704600, U28016
      UniProtKB/TrEMBL
      A2AUR3
      Conserved Domains (1) summary
      pfam02126
      Location:27 → 359
      PTE; Phosphotriesterase family

    3. NM_008961.3 → NP_032987.1  N-acetyltaurine hydrolase isoform 2

      See identical proteins and their annotated locations for NP_032987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks an exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK075604, AL929209, BB868274, BY704600, U28016
      Consensus CDS
      CCDS15691.1
      UniProtKB/Swiss-Prot
      A2AUR4, A2AUR6, Q60866, Q8BTA3
      UniProtKB/TrEMBL
      A2AUR3
      Related
      ENSMUSP00000117009.2, ENSMUST00000134794.8
      Conserved Domains (1) summary
      pfam02126
      Location:15 → 347
      PTE; Phosphotriesterase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      12928828..13008265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497402.3 → XP_006497465.1  phosphotriesterase-related protein isoform X3

      UniProtKB/TrEMBL
      A2AUR5
      Related
      ENSMUSP00000110444.4, ENSMUST00000114796.9
      Conserved Domains (1) summary
      cl00281
      Location:15 → 279
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    2. XM_006497401.3 → XP_006497464.1  phosphotriesterase-related protein isoform X2

      UniProtKB/TrEMBL
      A2AUR5
      Conserved Domains (1) summary
      cl00281
      Location:27 → 291
      metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...

    3. XM_017316438.2 → XP_017171927.1  phosphotriesterase-related protein isoform X1

      UniProtKB/TrEMBL
      A2AUR3
      Conserved Domains (1) summary
      pfam02126
      Location:27 → 359
      PTE; Phosphotriesterase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60866.1 GenPept UniProtKB/Swiss-Prot:Q60866

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