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    PRAC2 PRAC2 small nuclear protein [ Homo sapiens (human) ]

    Gene ID: 360205, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PRAC2provided by HGNC
    Official Full Name
    PRAC2 small nuclear proteinprovided by HGNC
    Primary source
    HGNC:HGNC:30143
    See related
    Ensembl:ENSG00000229637 MIM:610787; AllianceGenome:HGNC:30143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HOXBAS5; C17orf93; HOXB-AS5; HOXB13-AS1; NCRNA00253
    Summary
    This gene is highly expressed in prostate, rectum, colon, and testis. This gene may produce a non-coding RNA or may encode a short protein that might localize to the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in prostate (RPKM 2.7), colon (RPKM 1.1) and 1 other tissue See more
    Orthologs
    all
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    Genomic context

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    See PRAC2 in Genome Data Viewer
    Location:
    17q21.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (48718666..48724758)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (49582267..49588359)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (46800547..46802120)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2086 Neighboring gene ribosomal protein L9 pseudogene 28 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:46790297-46790470 Neighboring gene cytochrome c oxidase subunit 6B1 pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46799826-46800340 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:46800341-46800856 Neighboring gene microRNA 3185 Neighboring gene PRAC1 small nuclear protein Neighboring gene homeobox B13 Neighboring gene uncharacterized LOC105371811

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Inflammation-associated DNA methylation patterns in epithelium of ulcerative colitis. Barnicle A, et al. Epigenetics, 2017 Aug. PMID 28557546, Free PMC Article
    2. PRAC2: a new gene expressed in human prostate and prostate cancer. Olsson P, et al. Prostate, 2003 Jul 1. PMID 12746837
    3. Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma. Xiong Y, et al. Cancer Med, 2018 Sep. PMID 30105866, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our study indicated that HOXB13-AS1 could regulate HOXB13 gene expression by methylation HOXB13 promoter and acts as an epigenetic oncogenic in glioma.
      Title: Long noncoding RNA HOXB13-AS1 regulates HOXB13 gene methylation by interacting with EZH2 in glioma.
    2. PRAC2 may have a function in prostate growth and development(PRAC2)
      Title: PRAC2: a new gene expressed in human prostate and prostate cancer.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative protein PRAC2
    Names
    HOXB cluster antisense RNA 5
    prostate cancer susceptibility candidate 2
    prostate, rectum and colon 2
    prostate, rectum and colon expressed gene 2 protein
    prostate, rectum and colon expressed gene protein 2
    putative protein PRCA2
    small nuclear protein PRAC2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282275.2 → NP_001269204.1  putative protein PRAC2 isoform b precursor

      See identical proteins and their annotated locations for NP_001269204.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AF532777, AI201489, BX106051
      Consensus CDS
      CCDS74100.1
      UniProtKB/Swiss-Prot
      D3DTV9
      Related
      ENSP00000481367.1, ENST00000422730.4

    2. NM_001282276.1 → NP_001269205.1  putative protein PRAC2 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (a).
      Source sequence(s)
      AI201489, AI762586, BX106051
      Consensus CDS
      CCDS74099.1
      UniProtKB/TrEMBL
      A0A087X2F6
      Related
      ENSP00000484945.1, ENST00000432056.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      48718666..48724758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047435918.1 → XP_047291874.1  putative protein PRAC2 isoform X1

      UniProtKB/Swiss-Prot
      D3DTV9

    2. XM_011524747.2 → XP_011523049.1  putative protein PRAC2 isoform X1

      See identical proteins and their annotated locations for XP_011523049.1

      UniProtKB/Swiss-Prot
      D3DTV9

    3. XM_011524748.1 → XP_011523050.1  putative protein PRAC2 isoform X1

      See identical proteins and their annotated locations for XP_011523050.1

      UniProtKB/Swiss-Prot
      D3DTV9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      49582267..49588359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315954.1 → XP_054171929.1  putative protein PRAC2 isoform X1

      UniProtKB/Swiss-Prot
      D3DTV9

    2. XM_054315952.1 → XP_054171927.1  putative protein PRAC2 isoform X1

      UniProtKB/Swiss-Prot
      D3DTV9

    3. XM_054315953.1 → XP_054171928.1  putative protein PRAC2 isoform X1

      UniProtKB/Swiss-Prot
      D3DTV9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3DTV9.1 GenPept UniProtKB/Swiss-Prot:D3DTV9

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