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    NCAN neurocan [ Pan troglodytes (chimpanzee) ]

    Gene ID: 468775, updated on 3-Dec-2024

    Summary

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    Official Symbol
    NCANprovided by VGNC
    Official Full Name
    neurocanprovided by VGNC
    Primary source
    VGNC:VGNC:2306
    Locus tag
    CK820_G0026039
    See related
    Ensembl:ENSPTRG00000010734
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Also known as
    CSPG3
    Orthologs
    human mouse all
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    Genomic context

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    See NCAN in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 20 NC_072418.2 (21867384..21907731)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 19 NC_072417.1 (21867401..21907766)

    Chromosome 20 - NC_072418.2Genomic Context describing neighboring genes Neighboring gene BLOC-1 related complex subunit 8 Neighboring gene regulatory factor X associated ankyrin containing protein Neighboring gene nuclear receptor 2C2 associated protein Neighboring gene U6 spliceosomal RNA Neighboring gene hyaluronan and proteoglycan link protein 4 Neighboring gene transmembrane 6 superfamily member 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Accelerated evolution of nervous system genes in the origin of Homo sapiens. Dorus S, et al. Cell, 2004 Dec 29. PMID 15620360
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables hyaluronic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in glial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of neuroblast proliferation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in perineuronal net IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurocan core protein
    Names
    chondroitin sulfate proteoglycan 3 (neurocan)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034170.1 → NP_001029342.1  neurocan core protein precursor

      See identical proteins and their annotated locations for NP_001029342.1

      Status: PROVISIONAL

      Source sequence(s)
      AY665287
      UniProtKB/Swiss-Prot
      Q5IS41
      UniProtKB/TrEMBL
      A0A2J8LSS5, A0A663DE60, H2QFV0
      Conserved Domains (7) summary
      cd05902
      Location:51 → 161
      Ig_Neurocan; Immunoglobulin (Ig)-like domain of the chondroitin sulfate proteoglycan core protein (CSPG), neurocan
      cd00033
      Location:1215 → 1271
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:1046 → 1082
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd03517
      Location:160 → 254
      Link_domain_CSPGs_modules_1_3; Link_domain_CSPGs_modules_1_3; this extracellular link domain is found in the first and third link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan. In addition, it is found in the first link module of three other CSPGs: ...
      cd03520
      Location:261 → 356
      Link_domain_CSPGs_modules_2_4; Link_domain_CSPGs_modules_2_4; this link domain is found in the second and fourth link modules of the chondroitin sulfate proteoglycan core protein (CSPG) aggrecan and, in the second link module of three other CSPGs: versican, neurocan, and brevican. The ...
      pfam00008
      Location:1012 → 1042
      EGF; EGF-like domain
      cl02432
      Location:1088 → 1211
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072418.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      21867384..21907731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009435041.5 → XP_009433316.3  neurocan core protein isoform X1

      UniProtKB/TrEMBL
      A0A2J8LSS5, A0A663DE60, H2QFV0

    2. XM_009435039.5 → XP_009433314.3  neurocan core protein isoform X3

      UniProtKB/TrEMBL
      A0A2J8LSS5, A0A663DE60, H2QFV0

    3. XM_016934115.4 → XP_016789604.2  neurocan core protein isoform X2

      UniProtKB/TrEMBL
      A0A2J8LSQ5

    4. XM_054672482.2 → XP_054528457.1  neurocan core protein isoform X1

      UniProtKB/TrEMBL
      A0A2J8LSS5, A0A663DE60, H2QFV0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5IS41.1 GenPept UniProtKB/Swiss-Prot:Q5IS41

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials