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    GPR39 G protein-coupled receptor 39 [ Homo sapiens (human) ]

    Gene ID: 2863, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPR39provided by HGNC
    Official Full Name
    G protein-coupled receptor 39provided by HGNC
    Primary source
    HGNC:HGNC:4496
    See related
    Ensembl:ENSG00000183840 MIM:602886; AllianceGenome:HGNC:4496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZnR
    Summary
    This gene is a member of the ghrelin receptor family and encodes a rhodopsin-type G-protein-coupled receptor (GPCR). The encoded protein is involved in zinc-dependent signaling in epithelial tissue in intestines, prostate and salivary glands. The protein may also be involved in the pathophysiology of depression. [provided by RefSeq, Jun 2016]
    Expression
    Broad expression in brain (RPKM 4.2), colon (RPKM 3.1) and 19 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR39 in Genome Data Viewer
    Location:
    2q21.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (132416805..132646582)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (132855128..133084942)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (133174378..133404155)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:133119050-133119870 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:133160772-133161322 Neighboring gene uncharacterized LOC124905948 Neighboring gene Sharpr-MPRA regulatory region 6129 Neighboring gene NANOG hESC enhancer GRCh37_chr2:133177398-133178039 Neighboring gene Sharpr-MPRA regulatory region 6766 Neighboring gene family with sequence similarity 201 member B Neighboring gene RNA, U6 small nuclear 175, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:133225978-133226478 Neighboring gene microRNA 9986 Neighboring gene RN7SK pseudogene 103 Neighboring gene Y-box binding protein 1 pseudogene 7 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:133362908-133363464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:133426641-133427604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16540 Neighboring gene LY6/PLAUR domain containing 1 Neighboring gene NCK associated protein 5 Neighboring gene Sharpr-MPRA regulatory region 3189 Neighboring gene uncharacterized LOC112268439 Neighboring gene NCKAP5 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression. Jiang Y, et al. J Dent Res, 2020 Jul. PMID 32325008
    2. Obestatin: is it really doing something? Trovato L, et al. Front Horm Res, 2014. PMID 24732935
    3. Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39. Bassilana F, et al. Nat Chem Biol, 2014 May. PMID 24633354
    4. GPR39 Zn(2+)-sensing receptor: a new target in antidepressant development? Młyniec K, et al. J Affect Disord, 2015 Mar 15. PMID 25490458
    5. Zinc, future mono/adjunctive therapy for depression: Mechanisms of antidepressant action. Nowak G. Pharmacol Rep, 2015 Jun. PMID 25933983

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Expressions of zinc homeostasis proteins, GPR39 and ANO1 mRNA in the sperm of asthenozoospermia patients and their clinical significance].
      Title: [Expressions of zinc homeostasis proteins, GPR39 and ANO1 mRNA in the sperm of asthenozoospermia patients and their clinical significance].
    2. Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles.
      Title: Zinc-sensing receptor activation induces endothelium-dependent hyperpolarization-mediated vasorelaxation of arterioles.
    3. GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.
      Title: GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain.
    4. Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.
      Title: Signaling pathway mechanisms of neurological diseases induced by G protein-coupled receptor 39.
    5. G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling.
      Title: G protein-coupled receptor 39 alleviates mitochondrial dysfunction and hepatocyte lipid accumulation via SIRT1/Nrf2 signaling.
    6. Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
      Title: Inhibition of GPR39 restores defects in endothelial cell-mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis.
    7. The expression and clinical significance of GPR39 in colon cancer.
      Title: The expression and clinical significance of GPR39 in colon cancer.
    8. Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.
      Title: Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist.
    9. Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression.
      Title: Interaction between Zinc, GPR39, BDNF and Neuropeptides in Depression.
    10. GPR39 promotes cardiac hypertrophy by regulating the AMPK-mTOR pathway and protein synthesis.
      Title: GPR39 promotes cardiac hypertrophy by regulating the AMPK-mTOR pathway and protein synthesis.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC149541

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 39
    Names
    zinc sensing receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050928.1 RefSeqGene

      Range
      5645..235422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001508.3 → NP_001499.1  G-protein coupled receptor 39

      See identical proteins and their annotated locations for NP_001499.1

      Status: REVIEWED

      Source sequence(s)
      AI459805, BC125046, BM981455, DA636860, DA653793
      Consensus CDS
      CCDS2170.1
      UniProtKB/Swiss-Prot
      B2RC12, B6V9G4, O43194, Q08AS2, Q53R01
      UniProtKB/TrEMBL
      B3KV24
      Related
      ENSP00000327417.3, ENST00000329321.4
      Conserved Domains (1) summary
      cd15135
      Location:31 → 355
      7tmA_GPR39; G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      132416805..132646582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      132855128..133084942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43194.1 GenPept UniProtKB/Swiss-Prot:O43194

    Gene LinkOut

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