CEACAM1 CEA cell adhesion molecule 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CEACAM1provided by HGNC
Official Full Name: CEA cell adhesion molecule 1provided by HGNC
Primary source: HGNC:HGNC:1814
See related: Ensembl:ENSG00000079385 MIM:109770; AllianceGenome:HGNC:1814
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BGP; BGP1; BGPI
Summary: This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
Expression: Biased expression in colon (RPKM 99.7), esophagus (RPKM 21.9) and 12 other tissues See more
Orthologs: all
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Genomic context

Location:: 19q13.2

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (42507306..42528481, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (45326710..45347884, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (43011458..43032633, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Title: Loss of CEACAM1 in hepatocytes causes hepatic fibrosis.
Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.
Title: Conditional deletion of CEACAM1 in hepatic stellate cells causes their activation.
Spliced CEACAM1: A Potential Novel Biomarker and Target for Ameliorating Liver Ischemia-reperfusion Injury.
Title: Spliced CEACAM1: A Potential Novel Biomarker and Target for Ameliorating Liver Ischemia-reperfusion Injury.
The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer.
Title: The role of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer.
Alternative splicing of CEACAM1 by hypoxia-inducible factor-1alpha enhances tolerance to hepatic ischemia in mice and humans.
Title: Alternative splicing of CEACAM1 by hypoxia-inducible factor-1α enhances tolerance to hepatic ischemia in mice and humans.
Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis.
Title: Human CEACAM1 is targeted by a Streptococcus pyogenes adhesin implicated in puerperal sepsis pathogenesis.
CEACAM1 Is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma.
Title: CEACAM1 Is a Prognostic Biomarker and Correlated with Immune Cell Infiltration in Clear Cell Renal Cell Carcinoma.
NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
Title: NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.
TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8[+] T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome.
Title: TIM3/CEACAM1 pathway involves in myeloid-derived suppressor cells induced CD8(+) T cells exhaustion and bone marrow inflammatory microenvironment in myelodysplastic syndrome.
Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis.
Title: Increased CEACAM1 expression on peripheral blood neutrophils in patients with rheumatoid arthritis.

Submit: New GeneRIF Correction See all GeneRIFs (232)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in human primary T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-17429 (e-PCR)
- UniSTS:20736

D19S1014 (e-PCR)
- UniSTS:80201

SHGC-35228 (e-PCR)
- UniSTS:70555

STS-AA024986 (e-PCR)
- UniSTS:55717

STS-M72238 (e-PCR)
- UniSTS:55230

SHGC-35229 (e-PCR)
- UniSTS:51950

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables bile acid transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables calmodulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables filamin binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in angiogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in bile acid and bile salt transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood vessel development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell migration	NAS Non-traceable Author Statement more info	PubMed
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in common myeloid progenitor cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	NAS Non-traceable Author Statement more info	PubMed
involved_in insulin catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in insulin receptor internalization	ISS Inferred from Sequence or Structural Similarity more info
involved_in integrin-mediated signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cytotoxic T cell degranulation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of granulocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of lipid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of platelet aggregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of vascular permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood vessel remodeling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endothelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of homophilic cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of immune system process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in wound healing, spreading of cells	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in lateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microvillus membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in specific granule membrane	TAS Traceable Author Statement more info
located_in tertiary granule membrane	TAS Traceable Author Statement more info
located_in transport vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cell adhesion molecule CEACAM1; carcinoembryonic antigen-related cell adhesion molecule 1

Names: CD66a antigen; antigen CD66; carcinoembryonic antigen related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029051.2 RefSeqGene

Range

5029..26204

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001024912.3 → NP_001020083.1 cell adhesion molecule CEACAM1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001020083.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus and is shorter than isoform 1. This variant has been referred to by multiple names, including BGPc, transmembrane carcinoembryonic antigen 3, TM3-CEA, and CEACAM1-4S.

Source sequence(s)

AC004785, BC014473, BC024164, DA432598, X16354

Consensus CDS

CCDS46089.1

UniProtKB/TrEMBL

Q3KRG8

Related

ENSP00000384709.3, ENST00000403444.7

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001184813.2 → NP_001171742.1 cell adhesion molecule CEACAM1 isoform 4 precursor

See identical proteins and their annotated locations for NP_001171742.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate, in-frame, exon, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1.

Source sequence(s)

AC004785, DA432598, X14831

Consensus CDS

CCDS54273.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000244291.6, ENST00000352591.9

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184815.2 → NP_001171744.1 cell adhesion molecule CEACAM1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001171744.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has one and lacks a different alternate, in-frame, segment, compared to variant 1. The resulting protein (isoform 3) is shorter when it was compared to isoform 1. This variant has been referred to as 'alternative spliced isoform 3S' and 'short form 3'.

Source sequence(s)

AC004785, AK314211, M76743, X16354

Consensus CDS

CCDS54274.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000351165.2, ENST00000358394.7

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain
NM_001184816.2 → NP_001171745.1 cell adhesion molecule CEACAM1 isoform 5 precursor

See identical proteins and their annotated locations for NP_001171745.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two coding region segments, one of which shifts the reading frame, compared to variant 1. The resulting protein (isoform 5) has a shorter and distinct C-terminus when it is compared to isoform 1.

Source sequence(s)

AC004785, AY766113, DA432598, X16354

Consensus CDS

CCDS54272.1

UniProtKB/Swiss-Prot

P13688

Related

ENSP00000384083.1, ENST00000403461.5

Conserved Domains (5) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:323 → 355

DUF4690; Domain of unknown function (DUF4690)
NM_001205344.2 → NP_001192273.1 cell adhesion molecule CEACAM1 isoform 6 precursor

See identical proteins and their annotated locations for NP_001192273.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks a segment, which results in a frameshift, compared to variant 1. The resulting protein (isoform 6) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL833584, BC014473, BU161659, DA432598, J03858, X14831

UniProtKB/TrEMBL

Q3KRG8

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM; Immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain
NM_001712.5 → NP_001703.2 cell adhesion molecule CEACAM1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001703.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). This variant has been referred to by multiple names, including transmembrane carcinoembryonic antigen BGPa, TM1-CEA, and CEACAM1-4L.

Source sequence(s)

AC004785, DA432598, X16354

Consensus CDS

CCDS12609.1

UniProtKB/Swiss-Prot

A6NE38, A8MY49, O60430, P13688, Q069I7, Q13854, Q13857, Q13858, Q13859, Q13860, Q15600, Q15601, Q16170, Q5UB49, Q7KYP5, Q96CA7, Q9UQV9

UniProtKB/TrEMBL

Q3KRG8

Related

ENSP00000161559.6, ENST00000161559.11

Conserved Domains (7) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam07679
Location:317 → 408

I-set; Immunoglobulin I-set domain

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain

pfam15756
Location:419 → 451

DUF4690; Domain of unknown function (DUF4690)

cl11960
Location:340 → 415

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

42507306..42528481 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011527206.3 → XP_011525508.1 carcinoembryonic antigen-related cell adhesion molecule 1 isoform X1

See identical proteins and their annotated locations for XP_011525508.1

UniProtKB/Swiss-Prot

P13688

Conserved Domains (4) summary

cd05740
Location:146 → 233

Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

cd05774
Location:36 → 140

Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)

smart00410
Location:157 → 233

IG_like; Immunoglobulin like

pfam13895
Location:240 → 318

Ig_2; Immunoglobulin domain