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    FCER2 Fc epsilon receptor II [ Homo sapiens (human) ]

    Gene ID: 2208, updated on 10-Dec-2024

    Summary

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    Official Symbol
    FCER2provided by HGNC
    Official Full Name
    Fc epsilon receptor IIprovided by HGNC
    Primary source
    HGNC:HGNC:3612
    See related
    Ensembl:ENSG00000104921 MIM:151445; AllianceGenome:HGNC:3612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CD23; FCE2; CD23A; IGEBF; CLEC4J; FCErII; BLAST-2
    Summary
    The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
    Expression
    Biased expression in spleen (RPKM 20.9), lymph node (RPKM 16.3) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCER2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7688776..7702131, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7689661..7703156, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7753662..7767017, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9990 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 435 Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7749795-7749977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13897 Neighboring gene uncharacterized LOC105372262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13899 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7785915-7786414 Neighboring gene CLEC4G promoter region Neighboring gene C-type lectin domain family 4 member G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The CD23a and CD23b proximal promoters display different sensitivities to exogenous stimuli in B lymphocytes. Ewart MA, et al. Genes Immun, 2002 May. PMID 12070780
    2. CD23-mediated cell signaling in human B cells differs from signaling in cells of the monocytic lineage. Chan MA, et al. Clin Immunol, 2010 Dec. PMID 20805040
    3. CD23/FcεRII: molecular multi-tasking. Acharya M, et al. Clin Exp Immunol, 2010 Oct. PMID 20831712, Free PMC Article
    4. CD23-bound IgE augments and dominates recall responses through human naive B cells. Griffith QK, et al. J Immunol, 2011 Jan 15. PMID 21160045
    5. CD23-dependent transcytosis of IgE and immune complex across the polarized human respiratory epithelial cells. Palaniyandi S, et al. J Immunol, 2011 Mar 15. PMID 21307287

    See all (149) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
      Title: Role of CD23 Activated ERK Signaling Pathway in the Pathogenesis of Eosinophilic Chronic Sinusitis with Nasal Polyps.
    2. IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
      Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.
    3. An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
      Title: An FCER2 polymorphism is associated with increased oral leukotriene receptor antagonists and allergic rhinitis prescribing.
    4. Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
      Title: Reviving lost binding sites: Exploring calcium-binding site transitions between human and murine CD23.
    5. Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
      Title: Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease.
    6. Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
      Title: Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction.
    7. Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
      Title: Correlations between exhaled nitric oxide, rs28364072 polymorphism of FCER2 gene, asthma control, and inhaled corticosteroid responsiveness in children with asthma.
    8. CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
      Title: CD23 mediated the induction of pro-inflammatory cytokines Interleukin-1 beta and tumor necrosis factors-alpha in Aspergillus fumigatus keratitis.
    9. Human DC-SIGN and CD23 do not interact with human IgG.
      Title: Human DC-SIGN and CD23 do not interact with human IgG.
    10. FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.
      Title: FCER2 T2206C variant associated with FENO levels in asthmatic children using inhaled corticosteroids: The PACMAN study.
    Submit: New GeneRIF Correction See all GeneRIFs (103)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Fc fragment of IgE, low affinity receptor II (FCER2; CD23) in human B cells PubMed
    env CD23 protein membrane expression is upregulated by HIV-1 gp120 and this upregulation induces the production of nitric oxide (NO) and IL-1beta PubMed
    Envelope surface glycoprotein gp160, precursor env Antibodies against cell surface molecules LFA-1, ICAM-1, HLA-DR, and CD28 inhibit the HIV-1 gp160-induced B cell differentiation response; gp160 also induces IL-6R and CD23 molecule expression on B cells PubMed
    Nef nef In macrophages, activation of CD40 or expression of HIV-1 Nef induces the release of sCD23 and sICAM, which mediate effects on T lymphocytes, rendering them permissive to HIV-1 infection PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables IgE binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables integrin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables low-affinity IgE receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in B cell antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Fc receptor-mediated immune complex endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Fc-epsilon receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macrophage activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of humoral immune response mediated by circulating immunoglobulin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of nitric-oxide synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    low affinity immunoglobulin epsilon Fc receptor
    Names
    C-type lectin domain family 4, member J
    CD23 antigen
    Fc fragment of IgE receptor II
    Fc fragment of IgE, low affinity II, receptor for (CD23)
    FcepsilonRII
    fc-epsilon-RII
    immunoglobulin E-binding factor
    immunoglobulin epsilon-chain
    lymphocyte IgE receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029554.1 RefSeqGene

      Range
      5016..18371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001207019.3 → NP_001193948.2  low affinity immunoglobulin epsilon Fc receptor isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b, also known as CD23b) is shorter and has a distinct N-terminus, compared to isoform a. This variant is supported by data in PubMed IDs 12379312 and 15843555.
      Source sequence(s)
      AC008763, BC014108
      UniProtKB/TrEMBL
      K3W4U1
      Related
      ENSP00000353178.4, ENST00000360067.8
      Conserved Domains (2) summary
      smart00034
      Location:162 → 281
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:76 → 152
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_001220500.2 → NP_001207429.1  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001207429.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate donor splice site in the 5' UTR, compared to variant 1. Both variants 1 and 3 encode the same isoform (a, also known as CD23a).
      Source sequence(s)
      BC062591, DA957269
      Consensus CDS
      CCDS12184.1
      UniProtKB/Swiss-Prot
      P06734
      Related
      ENSP00000471974.1, ENST00000597921.6
      Conserved Domains (2) summary
      smart00034
      Location:163 → 282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77 → 153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_002002.5 → NP_001993.2  low affinity immunoglobulin epsilon Fc receptor isoform a

      See identical proteins and their annotated locations for NP_001993.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a, also known as CD23a). Both variants 1 and 3 encode the same isoform.
      Source sequence(s)
      BC014108, DA957269
      Consensus CDS
      CCDS12184.1
      UniProtKB/Swiss-Prot
      P06734
      Related
      ENSP00000264072.6, ENST00000346664.9
      Conserved Domains (2) summary
      smart00034
      Location:163 → 282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77 → 153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7688776..7702131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005272462.5 → XP_005272519.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

      See identical proteins and their annotated locations for XP_005272519.1

      UniProtKB/Swiss-Prot
      P06734
      Conserved Domains (2) summary
      smart00034
      Location:163 → 282
      CLECT; C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
      cl23720
      Location:77 → 153
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7689661..7703156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054320198.1 → XP_054176173.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

      UniProtKB/Swiss-Prot
      P06734
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P06734.1 GenPept UniProtKB/Swiss-Prot:P06734

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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