U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    cbll1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase [ Danio rerio (zebrafish) ]

    Gene ID: 394041, updated on 4-Jan-2025

    Summary

    Go to the top of the page Help
    Official Symbol
    cbll1provided by ZNC
    Official Full Name
    Cbl proto-oncogene-like 1, E3 ubiquitin protein ligaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-691
    See related
    Ensembl:ENSDARG00000015222 AllianceGenome:ZFIN:ZDB-GENE-040426-691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55308
    Summary
    Predicted to enable metal ion binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to be located in nucleus. Is expressed in telencephalon. Orthologous to human CBLL1 (Cbl proto-oncogene like 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cbll1 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18836791..18841071, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18847815..18852095, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137491543 Neighboring gene solute carrier family 26 member 3, tandem duplicate 2 Neighboring gene uncharacterized LOC110439362 Neighboring gene solute carrier family 26 member 3 Neighboring gene BCL2 interacting killer Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial)

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC55308

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    E3 ubiquitin-protein ligase Hakai
    Names
    Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
    NP_001296297.1
    NP_001296298.1
    NP_957360.2
    XP_017210471.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309368.1 → NP_001296297.1  E3 ubiquitin-protein ligase Hakai isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      BX649534, EH556329, EH577429
      UniProtKB/TrEMBL
      A0A8M1P6L1
      Conserved Domains (1) summary
      pfam13923
      Location:107 → 144
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    2. NM_001309369.1 → NP_001296298.1  E3 ubiquitin-protein ligase Hakai isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      BX649534, EH556329, EH577429
      UniProtKB/TrEMBL
      A0A8M1P220, F1QLJ4
      Related
      ENSDARP00000021149.7, ENSDART00000015834.8
      Conserved Domains (1) summary
      pfam13923
      Location:1 → 25
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    3. NM_201066.2 → NP_957360.2  E3 ubiquitin-protein ligase Hakai isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      BX649534, EH556329, EH577429
      UniProtKB/TrEMBL
      A0A8M1PDZ7, Q5RGV4
      Related
      ENSDARP00000066977.4, ENSDART00000066978.6
      Conserved Domains (1) summary
      pfam13923
      Location:100 → 137
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18836791..18841071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017354982.3 → XP_017210471.1  E3 ubiquitin-protein ligase Hakai isoform X1

      UniProtKB/TrEMBL
      A0A8M1PDZ7, Q5RGV4
      Conserved Domains (1) summary
      pfam13923
      Location:100 → 137
      zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.