Fmc1 formation of mitochondrial complex V assembly factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fmc1provided by RGD
Official Full Name: formation of mitochondrial complex V assembly factor 1provided by RGD
Primary source: RGD:1559476
See related: EnsemblRapid:ENSRNOG00000005618 AllianceGenome:RGD:1559476
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in mitochondrial proton-transporting ATP synthase complex assembly. Predicted to act upstream of or within negative regulation of lipid catabolic process and regulation of type B pancreatic cell proliferation. Predicted to be active in mitochondrion. Orthologous to several human genes including FMC1 (formation of mitochondrial complex V assembly factor 1 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 144.0), Muscle (RPKM 130.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (68241009..68249045)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (67274104..67282140)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (66276835..66284868)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial proton-transporting ATP synthase complex assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: protein FMC1 homolog

Names: UPF0562 protein C7orf55 homolog; formation of mitochondrial complex V assembly factor 1 homolog; formation of mitochondrial complexes 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037795.1 → NP_001032884.1 protein FMC1 homolog

See identical proteins and their annotated locations for NP_001032884.1

Status: PROVISIONAL

Source sequence(s)

BC098843

UniProtKB/Swiss-Prot

Q4G012

UniProtKB/TrEMBL

A6IES4

Related

ENSRNOP00000007544.2, ENSRNOT00000007544.5

Conserved Domains (1) summary

cd20271
Location:7 → 103

Complex1_LYR_FMC1; LYR (leucine-tyrosine-arginine) motif found in formation of mitochondrial complex V assembly factor 1 (FMC1) and similar proteins