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    S2bpcox16 synaptojanin 2 binding protein Cox16 readthrough [ Mus musculus (house mouse) ]

    Gene ID: 105940408, updated on 2-Nov-2024

    Summary

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    Official Symbol
    S2bpcox16provided by MGI
    Official Full Name
    synaptojanin 2 binding protein Cox16 readthroughprovided by MGI
    Primary source
    MGI:MGI:5141963
    See related
    Ensembl:ENSMUSG00000021139 AllianceGenome:MGI:5141963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arip2; Omp25; ARIP2a; Gm20498; Synj2bp; Synj2bp-cox16
    Summary
    This locus represents naturally occurring readthrough transcription between the neighboring Synj2bp (synaptojanin 2 binding protein) and Cox16 (cytochrome c oxidase assembly protein 16) genes on chromosome 12. The readthrough transcripts encode fusion proteins that share sequence similarity with each individual gene product. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2015]
    Expression
    Ubiquitous expression in testis adult (RPKM 7.7), bladder adult (RPKM 6.6) and 27 other tissues See more
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    Genomic context

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    See S2bpcox16 in Genome Data Viewer
    Location:
    12 D1; 12 37.6 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (81405626..81579685, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (81358852..81532911, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 3 Neighboring gene predicted gene 3693 Neighboring gene STARR-seq mESC enhancer starr_32669 Neighboring gene STARR-seq mESC enhancer starr_32670 Neighboring gene predicted gene, 53730 Neighboring gene cytochrome c oxidase assembly protein 16 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 4787 Neighboring gene heat shock protein 1 (chaperonin 10), pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_32671 Neighboring gene STARR-seq mESC enhancer starr_32672 Neighboring gene a disintegrin and metallopeptidase domain 4 Neighboring gene STARR-seq mESC enhancer starr_32673 Neighboring gene STARR-positive B cell enhancer ABC_E9388 Neighboring gene STARR-positive B cell enhancer ABC_E7157 Neighboring gene STARR-seq mESC enhancer starr_32674 Neighboring gene synaptojanin 2 binding protein Neighboring gene a disintegrin and metallopeptidase domain 21 Neighboring gene 40S ribosomal protein S23 pseudogene Neighboring gene mediator complex subunit 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel factors in regulation of activin signaling. Tsuchida K, et al. Mol Cell Endocrinol, 2004 Oct 15. PMID 15451561
    2. Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway. Matsuzaki T, et al. J Biol Chem, 2002 May 24. PMID 11882656
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in intracellular distribution of mitochondria ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Synj2bp-cox16 protein
    Names
    Activin receptor-interacting protein 2
    Activin receptor-interacting protein 4
    Mitochondrial outer membrane protein 25
    Synaptojanin-2-binding protein
    Synj2bp-cox16 readthrough
    activin receptor-interacting protein 2a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309847.1 → NP_001296776.1  Synj2bp-cox16 protein isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC132391, AC154908, AK148649
      UniProtKB/TrEMBL
      E9PVN6, Q3UFD0
      Related
      ENSMUSP00000131728.2, ENSMUST00000166664.2
      Conserved Domains (2) summary
      cd00992
      Location:13 → 97
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam14138
      Location:100 → 164
      COX16; Cytochrome c oxidase assembly protein COX16

    2. NM_001309848.1 → NP_001296777.1  Synj2bp-cox16 protein isoform 2

      See identical proteins and their annotated locations for NP_001296777.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon, differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC132391, AC154908, AY157057
      UniProtKB/TrEMBL
      Q6Y642
      Related
      ENSMUSP00000132941.2, ENSMUST00000164386.8
      Conserved Domains (2) summary
      cd00992
      Location:13 → 97
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam14138
      Location:100 → 146
      COX16; Cytochrome c oxidase assembly protein COX16

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      81405626..81579685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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