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    Gipc2 GIPC PDZ domain containing family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 54120, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gipc2provided by MGI
    Official Full Name
    GIPC PDZ domain containing family, member 2provided by MGI
    Primary source
    MGI:MGI:1889209
    See related
    Ensembl:ENSMUSG00000039131 AllianceGenome:MGI:1889209
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Semcap2; 2200002N01Rik
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; gut; liver; lung; and metanephros. Orthologous to human GIPC2 (GIPC PDZ domain containing family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 43.0), placenta adult (RPKM 43.0) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gipc2 in Genome Data Viewer
    Location:
    3 H3; 3 76.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (151799476..151871537, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (152093839..152165900, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31739 Neighboring gene STARR-seq mESC enhancer starr_09277 Neighboring gene VISTA enhancer mm2010 Neighboring gene STARR-seq mESC enhancer starr_09278 Neighboring gene STARR-seq mESC enhancer starr_09279 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene Neighboring gene predicted gene, 31881 Neighboring gene predicted gene, 40179 Neighboring gene STARR-seq mESC enhancer starr_09281 Neighboring gene STARR-seq mESC enhancer starr_09282 Neighboring gene STARR-seq mESC enhancer starr_09283 Neighboring gene DnaJ heat shock protein family (Hsp40) member B4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:151866980-151867163 Neighboring gene STARR-positive B cell enhancer ABC_E2101 Neighboring gene predicted gene, 40180 Neighboring gene STARR-seq mESC enhancer starr_09284 Neighboring gene far upstream element (FUSE) binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. La Torre A, et al. Stem Cells, 2015 Sep. PMID 26013465, Free PMC Article
    2. A PDZ protein regulates the distribution of the transmembrane semaphorin, M-SemF. Wang LH, et al. J Biol Chem, 1999 May 14. PMID 10318831
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PDZ domain-containing protein GIPC2
    Names
    SEMCAP-2
    semaF cytoplasmic domain associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016867.1 → NP_058563.1  PDZ domain-containing protein GIPC2

      See identical proteins and their annotated locations for NP_058563.1

      Status: PROVISIONAL

      Source sequence(s)
      AF061262
      Consensus CDS
      CCDS17914.1
      UniProtKB/Swiss-Prot
      Q9CVG2, Q9Z2H7
      Related
      ENSMUSP00000037328.9, ENSMUST00000046614.10
      Conserved Domains (1) summary
      cd00992
      Location:116 → 179
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      151799476..151871537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240165.2 → XP_011238467.1  PDZ domain-containing protein GIPC2 isoform X1

      Conserved Domains (1) summary
      cd00992
      Location:24 → 87
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2H7.1 GenPept UniProtKB/Swiss-Prot:Q9Z2H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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