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    FECH ferrochelatase [ Pan troglodytes (chimpanzee) ]

    Gene ID: 455437, updated on 3-Dec-2024

    Summary

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    Official Symbol
    FECHprovided by VGNC
    Official Full Name
    ferrochelataseprovided by VGNC
    Primary source
    VGNC:VGNC:5169
    Locus tag
    CK820_G0011396
    See related
    Ensembl:ENSPTRG00000010045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See FECH in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 17 NC_072415.2 (67614286..67652014, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 18 NC_072416.1 (66550731..66588447, complement)

    Chromosome 17 - NC_072415.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134808617 Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 Neighboring gene one cut homeobox 2 Neighboring gene uncharacterized LOC134808618 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene ATPase phospholipid transporting 8B1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Contribution of a common single-nucleotide polymorphism to the genetic predisposition for erythropoietic protoporphyria. Gouya L, et al. Am J Hum Genet, 2006 Jan. PMID 16385445, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ferrochelatase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferrochelatase, mitochondrial
    Names
    ferrochelatase (protoporphyria)
    heme synthase
    heme synthetase
    protoheme ferro-lyase
    NP_001033101.1
    XP_016788687.1
    XP_016788688.1
    XP_016788690.1
    XP_016788692.1
    XP_016788693.1
    XP_054527641.1
    XP_054527642.1
    XP_054527643.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038012.1 → NP_001033101.1  ferrochelatase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001033101.1

      Status: PROVISIONAL

      Source sequence(s)
      DQ149645
      UniProtKB/Swiss-Prot
      Q3YA36
      UniProtKB/TrEMBL
      K7A567
      Related
      ENSPTRP00000054886.4, ENSPTRT00000062330.4
      Conserved Domains (3) summary
      cd00419
      Location:235 → 372
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:69 → 230
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:69 → 389
      Ferrochelatase; Ferrochelatase

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072415.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      67614286..67652014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054671667.2 → XP_054527642.1  ferrochelatase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      K7A567

    2. XM_054671666.2 → XP_054527641.1  ferrochelatase, mitochondrial isoform X3

      UniProtKB/TrEMBL
      K7A567

    3. XM_016933201.4 → XP_016788690.1  ferrochelatase, mitochondrial isoform X4

      UniProtKB/TrEMBL
      K7A567

    4. XM_016933199.4 → XP_016788688.1  ferrochelatase, mitochondrial isoform X2

      UniProtKB/TrEMBL
      K7A567
      Conserved Domains (3) summary
      cd00419
      Location:241 → 366
      Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      cd03411
      Location:75 → 236
      Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
      pfam00762
      Location:75 → 375
      Ferrochelatase; Ferrochelatase

    5. XM_016933198.4 → XP_016788687.1  ferrochelatase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A2I3REE8, A0A2J8NDP1, A0A6D2XZB8, K7A567
      Related
      ENSPTRP00000063006.1
      Conserved Domains (1) summary
      pfam00762
      Location:75 → 395
      Ferrochelatase; Ferrochelatase

    6. XM_016933204.4 → XP_016788693.1  ferrochelatase, mitochondrial isoform X6

      UniProtKB/TrEMBL
      H2RB24
      Conserved Domains (1) summary
      pfam00762
      Location:1 → 317
      Ferrochelatase

    7. XM_016933203.4 → XP_016788692.1  ferrochelatase, mitochondrial isoform X6

      UniProtKB/TrEMBL
      H2RB24
      Conserved Domains (1) summary
      pfam00762
      Location:1 → 317
      Ferrochelatase

    8. XM_054671668.2 → XP_054527643.1  ferrochelatase, mitochondrial isoform X6

      UniProtKB/TrEMBL
      H2RB24
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YA36.1 GenPept UniProtKB/Swiss-Prot:Q3YA36

    Gene LinkOut

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