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    CEBPD CCAAT enhancer binding protein delta [ Homo sapiens (human) ]

    Gene ID: 1052, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CEBPDprovided by HGNC
    Official Full Name
    CCAAT enhancer binding protein deltaprovided by HGNC
    Primary source
    HGNC:HGNC:1835
    See related
    Ensembl:ENSG00000221869 MIM:116898; AllianceGenome:HGNC:1835
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CELF; CRP3; C/EBP-delta; NF-IL6-beta
    Summary
    The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
    Orthologs
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    Genomic context

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    See CEBPD in Genome Data Viewer
    Location:
    8q11.21
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (47736913..47738164, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (48112630..48113881, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48649475..48650726, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene scaffold protein involved in DNA repair Neighboring gene ubiquitin conjugating enzyme E2 N pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19171 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48552828-48553328 Neighboring gene RNA, U6 small nuclear 665, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48649750-48650688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48664855-48665355 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27329 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:48678117-48678684 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:48734487-48735248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48737843-48738343 Neighboring gene Sharpr-MPRA regulatory region 7649 Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48770411-48770910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27330 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48836071-48836571 Neighboring gene uncharacterized LOC105375818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48867403-48867904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19177 Neighboring gene origin of replication upstream of MCM4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19179 Neighboring gene minichromosome maintenance complex component 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CCAAT/enhancer binding protein delta (C/EBPdelta) expression and elevation in Alzheimer's disease. Li R, et al. Neurobiol Aging, 2004 Sep. PMID 15212823
    2. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. Kaji H, et al. Metab Syndr Relat Disord, 2008 Mar. PMID 18370833
    3. C/EBPδ drives interactions between human MAIT cells and endothelial cells that are important for extravasation. Lee CH, et al. Elife, 2018 Feb 22. PMID 29469805, Free PMC Article
    4. The C/EBPdelta tumor suppressor is silenced by hypermethylation in acute myeloid leukemia. Agrawal S, et al. Blood, 2007 May 1. PMID 17234736
    5. HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells. Li CF, et al. Mol Cancer Ther, 2015 Nov. PMID 26358750

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation.
      Title: Systematic transcriptome profiling of hPSC-derived osteoblasts unveils CORIN's mastery in governing osteogenesis through CEBPD modulation.
    2. CCAAT enhancer binding protein delta activates vesicle associated membrane protein 3 transcription to enhance chemoresistance and extracellular PD-L1 expression in triple-negative breast cancer.
      Title: CCAAT enhancer binding protein delta activates vesicle associated membrane protein 3 transcription to enhance chemoresistance and extracellular PD-L1 expression in triple-negative breast cancer.
    3. Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
      Title: Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD.
    4. C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
      Title: C/EBP-Family Redundancy Determines Patient Survival and Lymph Node Involvement in PDAC.
    5. C/EBPdelta Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration.
      Title: C/EBPδ Suppresses Motility-Associated Gene Signatures and Reduces PDAC Cell Migration.
    6. CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection.
      Title: CCAAT/enhancer binding protein (C/EBP) delta promotes the expression of PTX3 and macrophage phagocytosis during A. fumigatus infection.
    7. Angiogenesis Driven by the CEBPD-hsa-miR-429-VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression.
      Title: Angiogenesis Driven by the CEBPD-hsa-miR-429-VEGFA Signaling Axis Promotes Urothelial Carcinoma Progression.
    8. C/EBPdelta drives key endocrine signals in the human amnion at parturition.
      Title: C/EBPδ drives key endocrine signals in the human amnion at parturition.
    9. PERK signaling through C/EBPdelta contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.
      Title: PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells.
    10. Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.
      Title: Non-Tumor CCAAT/Enhancer-Binding Protein Delta Potentiates Tumor Cell Extravasation and Pancreatic Cancer Metastasis Formation.
    Submit: New GeneRIF Correction See all GeneRIFs (80)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates C/EBPdelta expression in human mesenchymal stem cells PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of CCAAT/enhancer binding protein (C/EBP), delta (CEBPD) in primary human brain microvascular endothelial cells PubMed
    Vpr vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of CXCL8 (IL8) in astrocytes PubMed
    vpr HIV-1 Vpr involves the CEBPD (C/EBP-delta) transcription factor in the induction of IL6 in astrocytes PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inner ear development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in integrated stress response signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of RNA polymerase II transcription regulator complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CCAAT/enhancer-binding protein delta
    Names
    CCAAT/enhancer binding protein (C/EBP), delta
    c/EBP delta
    nuclear factor NF-IL6-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005195.4 → NP_005186.2  CCAAT/enhancer-binding protein delta

      See identical proteins and their annotated locations for NP_005186.2

      Status: REVIEWED

      Source sequence(s)
      AC023991, BC105109, BQ773696, M83667
      Consensus CDS
      CCDS6142.1
      UniProtKB/Swiss-Prot
      P49716, Q14937, Q2M2X9
      Related
      ENSP00000386165.3, ENST00000408965.4
      Conserved Domains (1) summary
      cd14714
      Location:188 → 252
      bZIP_CEBPD; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein delta (CEBPD): a DNA-binding and dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      47736913..47738164 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      48112630..48113881 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49716.2 GenPept UniProtKB/Swiss-Prot:P49716

    Gene LinkOut

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