Ffar4 free fatty acid receptor 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ffar4provided by RGD
Official Full Name: free fatty acid receptor 4provided by RGD
Primary source: RGD:1308252
See related: EnsemblRapid:ENSRNOG00000021763 AllianceGenome:RGD:1308252
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr120; O3far1
Summary: Predicted to enable arrestin family protein binding activity; fatty acid binding activity; and transmembrane signaling receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in cilium; cytoplasmic vesicle; and lysosomal membrane. Predicted to be active in plasma membrane. Orthologous to human FFAR4 (free fatty acid receptor 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 31.4), Thymus (RPKM 26.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q53

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (245286009..245304029)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (235873576..235891597)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (256786124..256804156)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings suggest that GPR120, the sensing receptor for extracorporeal shockwave treatment, may be useful in the treatment of interstitial cystitis by inhibiting inflammatory response in bladder cells.
Title: Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.
These present data have shown for the first time that total mRNA isolation and protein expression from both adipose tissues (abdominal and subcutaneous) of rat in obesity condition yield significative statistical difference among the control versus obese groups, showing that the diet high in carbohydrates modifies the total presence of mRNA and protein level expression of the receptors GPR41, 43 and 120
Title: Characterization of free fatty acid receptors expression in an obesity rat model with high sucrose diet.
GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy
Title: GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Data show that G protein-coupled receptor 120 protein (GPR120) appears strongly on interstitial cells and also on spermatogenic cells.
Title: Arachidonic acid triggers [Ca2+]i increases in rat round spermatids by a likely GPR activation, ERK signalling and ER/acidic compartments Ca2+ release.
GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma.
Title: Insulinotropic effects of GPR120 agonists are altered in obese diabetic and obese non-diabetic states.
demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders
Title: A novel anti-inflammatory role of GPR120 in intestinal epithelial cells.
results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles
Title: Endogenous Ligand for GPR120, Docosahexaenoic Acid, Exerts Benign Metabolic Effects on the Skeletal Muscles via AMP-activated Protein Kinase Pathway.
These results suggest that GPR120 plays an important role in the cell motile activity induced by TPA in WB-F344 cells.
Title: Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells.
opposite effects of GPR120 and GPR40 may be involved in the cell motile activity stimulated by ethionine in WB-F344 cells
Title: Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells.
These data shows a widespread expression of GPR120 in the gut epithelium and can not confirm a major role for GPR120 in the regulation of GLP-1 secretion.
Title: Expression of the fatty acid receptor GPR120 in the gut of diet-induced-obese rats and its role in GLP-1 secretion.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables arrestin family protein binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid binding	ISO Inferred from Sequence Orthology more info
enables fatty acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables taste receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in brown fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of chemical stimulus involved in sensory perception of taste	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ghrelin secretion	ISO Inferred from Sequence Orthology more info
involved_in ghrelin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in hormone secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of somatostatin secretion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of somatostatin secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of brown fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucagon secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glucagon secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of D-glucose transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of D-glucose transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in white fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in white fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in cilium	ISS Inferred from Sequence or Structural Similarity more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: free fatty acid receptor 4

Names: G-protein coupled receptor 120; omega-3 fatty acid receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.