pld-1 Phospholipase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pld-1
Official Full Name: Phospholipase
Primary source: WormBase:WBGene00004040
Locus tag: CELE_C04G6.3
See related: AllianceGenome:WB:WBGene00004040
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable phospholipase D activity. Predicted to be involved in phospholipid catabolic process and regulation of vesicle-mediated transport. Predicted to be active in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including intestine; nervous system; pharyngeal-intestinal valve; rectal gland cell; and reproductive system. Human ortholog(s) of this gene implicated in developmental cardiac valvular defect. Orthologous to several human genes including PLD1 (phospholipase D1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pld-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 18

Sequence:: Chromosome: II; NC_003280.10 (5083848..5091690, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We show that pld-1 animals present decreased phosphatidic acid levels, that PLD is the only source of total PLD activity and that pld-1 animals are more sensitive to the acute effects of ethanol.
Title: Phospholipase D functional ablation has a protective effect in an Alzheimer's disease Caenorhabditis elegans model.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C04G6.5 (e-PCR)
- UniSTS:315403

C04G6.3 (e-PCR)
- UniSTS:308463

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables N-acylphosphatidylethanolamine-specific phospholipase D activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phospholipase D activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase D activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidic acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Phospholipase

NP_494939.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

5083848..5091690 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_062538.7 → NP_494939.1 Phospholipase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_494939.1

Status: REVIEWED

UniProtKB/TrEMBL

G5EDU3

Conserved Domains (5) summary

cd09138
Location:528 → 674

PLDc_vPLD1_2_yPLD_like_1; Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins

cd09141
Location:1101 → 1278

PLDc_vPLD1_2_yPLD_like_2; Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, yeast PLDs, and similar proteins

PLN02866
Location:988 → 1426

PLN02866; phospholipase D

cd01254
Location:372 → 502

PH_PLD; Phospholipase D pleckstrin homology (PH) domain

cl02563
Location:153 → 384

PX_domain; The Phox Homology domain, a phosphoinositide binding module