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    Ptpn5 protein tyrosine phosphatase, non-receptor type 5 [ Mus musculus (house mouse) ]

    Gene ID: 19259, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptpn5provided by MGI
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 5provided by MGI
    Primary source
    MGI:MGI:97807
    See related
    Ensembl:ENSMUSG00000030854 AllianceGenome:MGI:97807
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Step
    Summary
    Enables protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in several cellular components, including perikaryon; proximal dendrite; and synaptic vesicle. Predicted to be active in cell junction; cytosol; and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; genitourinary system; retina; and submandibular gland. Orthologous to human PTPN5 (protein tyrosine phosphatase non-receptor type 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 44.4), whole brain E14.5 (RPKM 40.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptpn5 in Genome Data Viewer
    Location:
    7 B3; 7 30.7 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46727543..46783774, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (47077795..47134026, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 22-like Neighboring gene transmembrane protein 86A Neighboring gene microRNA 7056 Neighboring gene STARR-seq mESC enhancer starr_18879 Neighboring gene STARR-positive B cell enhancer ABC_E4928 Neighboring gene predicted gene 14377 Neighboring gene STARR-seq mESC enhancer starr_18880 Neighboring gene STARR-positive B cell enhancer mm9_chr7:54405971-54406272 Neighboring gene MAS-related GPR, member A6 Neighboring gene MAS-related GPR, member A1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases. Sharma E, et al. Brain Res Mol Brain Res, 1995 Aug. PMID 7494467
    2. The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications. Carty NC, et al. Transl Psychiatry, 2012 Jul 10. PMID 22781170, Free PMC Article
    3. Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory. Venkitaramani DV, et al. Eur J Neurosci, 2011 Jun. PMID 21501258, Free PMC Article
    4. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Hicklin TR, et al. Proc Natl Acad Sci U S A, 2011 Apr 19. PMID 21464302, Free PMC Article
    5. Tyrosine phosphatase STEP61 negatively regulates amyloid β-mediated ERK/CREB signaling pathways via α7 nicotinic acetylcholine receptors. Zhang L, et al. J Neurosci Res, 2013 Dec. PMID 24123152

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
      Title: Mechanisms of mGluR-dependent plasticity in hippocampal area CA2.
    2. Tyrosine phosphatase STEP61 in human dementia and in animal models with amyloid and tau pathology.
      Title: Tyrosine phosphatase STEP(61) in human dementia and in animal models with amyloid and tau pathology.
    3. Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP61) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
      Title: Reelin Regulates Neuronal Excitability through Striatal-Enriched Protein Tyrosine Phosphatase (STEP(61)) and Calcium Permeable AMPARs in an NMDAR-Dependent Manner.
    4. Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
      Title: Regulation of post-ischemic inflammatory response: A novel function of the neuronal tyrosine phosphatase STEP.
    5. Levels of Ptpn5 protein are elevated in a mouse model of sepsis-associated encephalopathy with associated decreases in phosphorylated forms of GluN2B, CREB, PSD95, ERK1, BDNF, and ERK2.
      Title: Disruption of Striatal-Enriched Protein Tyrosine Phosphatase Signaling Might Contribute to Memory Impairment in a Mouse Model of Sepsis-Associated Encephalopathy.
    6. Deletion of STEP has a beneficial effect on motor coordination and cognition in a mouse model of Huntington's disease.
      Title: Pharmacogenetic modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.
    7. STEP61 undergoes proteolytic degradation in conditions leading to synaptic strengthening and memory formation
      Title: Proteolytic Degradation of Hippocampal STEP(61) in LTP and Learning.
    8. activation of synaptic NMDAR by bicuculline or D-serine results in the ubiquitination and proteasomal degradation of STEP61, and increased surface localization of GluN1/GluN2B receptors.
      Title: Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP(61).
    9. STEP plays an important role at nerve terminals in the regulation of Ca(2+) homeostasis and neurotransmitter release.
      Title: Altered Intracellular Calcium Homeostasis Underlying Enhanced Glutamatergic Transmission in Striatal-Enriched Tyrosine Phosphatase (STEP) Knockout Mice.
    10. STEP61 degradation is an important event in BDNF-mediated effects.
      Title: BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotyrosine residue binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exploration behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of long-term synaptic potentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein targeting to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of receptor internalization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of response to drug ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to immobilization stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in proximal dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 5
    Names
    neural-specific protein-tyrosine phosphatase
    striatum-enriched protein-tyrosine phosphatase
    NP_001157037.1
    NP_001404109.1
    NP_038671.2
    XP_006540776.1
    XP_006540777.1
    XP_017177535.1
    XP_030098098.1
    XP_036008691.1
    XP_036008692.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163565.2 → NP_001157037.1  tyrosine-protein phosphatase non-receptor type 5

      See identical proteins and their annotated locations for NP_001157037.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
      Source sequence(s)
      AC113001
      Consensus CDS
      CCDS21294.1
      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Related
      ENSMUSP00000033142.6, ENSMUST00000033142.13
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    2. NM_001417180.1 → NP_001404109.1  tyrosine-protein phosphatase non-receptor type 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC113001
      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9

    3. NM_013643.3 → NP_038671.2  tyrosine-protein phosphatase non-receptor type 5

      See identical proteins and their annotated locations for NP_038671.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All three variants encode the same protein.
      Source sequence(s)
      AC113001
      Consensus CDS
      CCDS21294.1
      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Related
      ENSMUSP00000099686.2, ENSMUST00000102626.10
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46727543..46783774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242238.1 → XP_030098098.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    2. XM_006540714.4 → XP_006540777.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      See identical proteins and their annotated locations for XP_006540777.1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    3. XM_006540713.4 → XP_006540776.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      See identical proteins and their annotated locations for XP_006540776.1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    4. XM_036152798.1 → XP_036008691.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    5. XM_036152799.1 → XP_036008692.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5

    6. XM_017322046.2 → XP_017177535.1  tyrosine-protein phosphatase non-receptor type 5 isoform X1

      UniProtKB/Swiss-Prot
      P54830, Q64694, Q8CAN0
      UniProtKB/TrEMBL
      Q80WU9
      Conserved Domains (1) summary
      cd14613
      Location:274 → 531
      PTPc-N5; catalytic domain of tyrosine-protein phosphatase non-receptor type 5
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54830.2 GenPept UniProtKB/Swiss-Prot:P54830

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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