alpl alkaline phosphatase, biomineralization associated [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: alplprovided by ZNC
Official Full Name: alkaline phosphatase, biomineralization associatedprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040420-1
See related: Ensembl:ENSDARG00000015546 AllianceGenome:ZFIN:ZDB-GENE-040420-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: alp; Akp2; zgc:56672
Summary: Predicted to enable alkaline phosphatase activity. Acts upstream of or within bone mineralization and response to mechanical stimulus. Predicted to be located in side of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural keel; brain; cardiovascular system; eye; and opercular flap. Human ortholog(s) of this gene implicated in adult hypophosphatasia; childhood hypophosphatasia; hypophosphatasia; and infantile hypophosphatasia. Orthologous to human ALPL (alkaline phosphatase, biomineralization associated). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (27968827..28012012)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (27721602..27766233)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development.
Title: Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alkaline phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkaline phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biomineral tissue development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within biomineral tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alkaline phosphatase, tissue-nonspecific isozyme

Names: alkaline phosphatase, liver/bone/kidney; tissue-nonspecific alkaline phosphatase

NP_957301.2

EC 3.1.3.1

XP_005169330.1

EC 3.1.3.1

XP_021335242.1

EC 3.1.3.1

XP_068080231.1

EC 3.1.3.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201007.2 → NP_957301.2 alkaline phosphatase, tissue-nonspecific isozyme

Status: VALIDATED

Source sequence(s)

BX248318

UniProtKB/TrEMBL

A0A8M1PDW2, F1Q5B5

Related

ENSDARP00000117214.1, ENSDART00000146461.3

Conserved Domains (1) summary

pfam00245
Location:88 → 526

Alk_phosphatase; Alkaline phosphatase

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007122.7 Reference GRCz11 Primary Assembly

Range

27968827..28012012

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005169273.5 → XP_005169330.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X2

UniProtKB/TrEMBL

A0A8M2BGI2

Conserved Domains (1) summary

pfam00245
Location:54 → 492

Alk_phosphatase; Alkaline phosphatase
XM_068224130.1 → XP_068080231.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X3
XM_021479567.2 → XP_021335242.1 alkaline phosphatase, tissue-nonspecific isozyme isoform X1

UniProtKB/TrEMBL

A0A8M9PUR2

Conserved Domains (1) summary

pfam00245
Location:81 → 519

Alk_phosphatase; Alkaline phosphatase