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    cg combgap [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36571, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cgprovided by FlyBase
    Official Full Name
    combgapprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000289
    Locus tag
    Dmel_CG8367
    See related
    AllianceGenome:FB:FBgn0000289
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cg; CG; CG8367; Combgap; Dmel\CG8367; l(2)07659; l(2)k11504; mig
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in imaginal disc-derived wing morphogenesis. Located in nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. Orthologous to several human genes including ZNF221 (zinc finger protein 221); ZNF284 (zinc finger protein 284); and ZNF41 (zinc finger protein 41). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    Location:
    50E1-50E1; 2-69 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (14173693..14182838)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (10061198..10070343)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44368 Neighboring gene uncharacterized protein Neighboring gene Receptor expression enhancing protein B Neighboring gene mitochondrial ribosomal protein S16 Neighboring gene SAXO downstream of blistered Neighboring gene Vesicular GABA Transporter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Su(Hw) interacts with Combgap to establish long-range chromatin contacts. Vorobyeva NE, et al. Epigenetics Chromatin, 2024 May 21. PMID 38773468, Free PMC Article
    2. Biometrical analysis of larval digging behavior in Drosophila melanogaster. Godoy-Herrera R. Behav Genet, 1994 Sep. PMID 7993319
    3. Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C. Hitrik A, et al. PLoS Genet, 2016 Nov. PMID 27846223, Free PMC Article
    4. Developmental genetics of the mutant combgap in Drosophila melanogaster. I. Effect on the morphology and chaetotaxy of the prothoracic leg. Datta RK, et al. Genetics, 1971 Jun. PMID 5099237, Free PMC Article
    5. Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-specific fashion. Minervini CF, et al. Gene, 2007 May 15. PMID 17343996

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A search for co-factors identified the ubiquitously expressed Combgap (Cg) as a novel transcriptional partner that impedes cell cycle exit and interferes with Eya-So activity specifically in this context. Cg acts as a flexible transcriptional platform that contributes to numerous gene expression outcomes by a variety of mechanisms.
      Title: Pleiotropy in Drosophila organogenesis: Mechanistic insights from Combgap and the retinal determination gene network.
    2. Uncover a novel role for Eya and So in promoting cell cycle exit in the retinal second mitotic wave (SMW), a synchronized, terminal cell division that occurs several hours after passage of the furrow. We show that Combgap (Cg), a zinc-finger transcription factor, antagonizes Eya-So function in the SMW.
      Title: Antagonistic regulation of the second mitotic wave by Eyes absent-Sine oculis and Combgap coordinates proliferation and specification in the Drosophila retina.
    3. Polytene chromosome stains showed that Cg co-localizes with EcR, the major regulator of BR-C, at the BR-C locus and that EcR binding to chromatin was sensitive to changes in Cg levels
      Title: Combgap Promotes Ovarian Niche Development and Chromatin Association of EcR-Binding Regions in BR-C.
    4. Combgap binds to GTGT motifs, which are present within the regulatory regions of Polycomb group target genes. Genome-wide analyses suggest that Combgap may directly recruit Polyhomeotic, a Polycomb group protein.
      Title: Combgap contributes to recruitment of Polycomb group proteins in Drosophila.
    5. combgap relays wingless signal reception to the determination of cortical cell fate in the visual system
      Title: Combgap relays wingless signal reception to the determination of cortical cell fate in the Drosophila visual system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    combgap
    Names
    CG8367-PA
    CG8367-PB
    CG8367-PC
    CG8367-PD
    CG8367-PF
    CG8367-PI
    CG8367-PJ
    CG8367-PK
    CG8367-PL
    CG8367-PM
    CG8367-PN
    cg-PA
    cg-PB
    cg-PC
    cg-PD
    cg-PF
    cg-PI
    cg-PJ
    cg-PK
    cg-PL
    cg-PM
    cg-PN
    comb gap
    migraine
    NP_001097306.2
    • unusual splice
    NP_001286409.1
    • unusual splice
    NP_001303348.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      14173693..14182838
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103836.4 → NP_001097306.2  combgap, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097306.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYD1, C9QPD9
      Conserved Domains (5) summary
      cd11674
      Location:491 → 603
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:287 → 371
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:294 → 314
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:306 → 331
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:425 → 465
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    2. NM_001103834.4 → NP_001097304.2  combgap, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097304.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYD2, C9QPD9
      Conserved Domains (5) summary
      cd11674
      Location:479 → 591
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:275 → 359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:282 → 302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:294 → 319
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:413 → 453
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    3. NM_001103835.2 → NP_001097305.1  combgap, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097305.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYD3, C9QPD9
      Conserved Domains (2) summary
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:286 → 311
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001316419.1 → NP_001303348.1  combgap, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A126GUP1, Q9NI49
      Conserved Domains (4) summary
      cd11674
      Location:439 → 499
      lambda-1; inner capsid protein lambda-1 or VP3
      sd00017
      Location:188 → 208
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:285 → 310
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:320 → 360
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    5. NM_001299480.1 → NP_001286409.1  combgap, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286409.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LFC7, C9QPD9
      Conserved Domains (5) summary
      cd11674
      Location:539 → 599
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:282 → 366
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 309
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:301 → 326
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:420 → 460
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    6. NM_001144194.2 → NP_001137666.1  combgap, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137666.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZE6, C9QPD9
      Conserved Domains (2) summary
      sd00017
      Location:282 → 302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:294 → 319
      zf-H2C2_2; Zinc-finger double domain

    7. NM_166034.2 → NP_725362.1  combgap, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725362.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9M3, C9QPD9
      Related
      FBpp0086656
      Conserved Domains (5) summary
      cd11674
      Location:479 → 591
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:275 → 359
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:282 → 302
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:294 → 319
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:413 → 453
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    8. NM_079014.3 → NP_523738.2  combgap, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523738.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KHK4, Q9NI49
      Related
      FBpp0086655
      Conserved Domains (2) summary
      sd00017
      Location:181 → 201
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:193 → 218
      zf-H2C2_2; Zinc-finger double domain

    9. NM_001299479.1 → NP_001286408.1  combgap, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286408.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LF29, Q9NI49
      Conserved Domains (4) summary
      cd11674
      Location:424 → 484
      lambda-1; inner capsid protein lambda-1 or VP3
      sd00017
      Location:173 → 193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:270 → 295
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:305 → 345
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    10. NM_166036.2 → NP_725364.1  combgap, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725364.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9M4, Q9NI49
      Related
      FBpp0086657
      Conserved Domains (5) summary
      cd11674
      Location:336 → 448
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:132 → 216
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:139 → 159
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:151 → 176
      zf-H2C2_2; Zinc-finger double domain
      cl00195
      Location:270 → 310
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    11. NM_166035.2 → NP_725363.1  combgap, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725363.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KHK4, Q9NI49
      Related
      FBpp0086658
      Conserved Domains (2) summary
      sd00017
      Location:181 → 201
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:193 → 218
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LF29 A0A0B4LF29
    A0A0B4LFC7 A0A0B4LFC7
    A0A126GUP1 A0A126GUP1
    A1Z9M3 A1Z9M3
    A1Z9M4 A1Z9M4
    A8DYD1 A8DYD1
    A8DYD2 A8DYD2
    A8DYD3 A8DYD3
    B7YZE6 B7YZE6
    Q7KHK4 Q7KHK4
    Q8IGK0 Q8IGK0
    Q8T0L4 Q8T0L4
    Q95RL3 Q95RL3
    Q9GT73 Q9GT73
    Q9NI49 Q9NI49

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