foxo forkhead box, sub-group O [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: foxoprovided by FlyBase
Official Full Name: forkhead box, sub-group Oprovided by FlyBase
Primary source: FLYBASE:FBgn0038197
Locus tag: Dmel_CG3143
See related: AllianceGenome:FB:FBgn0038197
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 3143; Afx; Akh; anon-WO0118547.374; cg3143; CG3143; dfoxo; dfoxO; dFoxo; dFoxO; dFOXO; Dfoxo; DfoxO; DFOXO; Dmel\CG3143; DmQ95V5; fd88A; FKHR; foxO; fOXO; Foxo; FoxO; FOXO; Foxo1; FOXO1; Q95V55; TORC
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of autophagy; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of with a negative effect on regulation of hemocyte proliferation and regulation of organ growth. Located in cytosol and nucleus. Is expressed in several structures, including embryonic segment; embryonic/larval midgut primordium; epidermis; fat body; and gut section. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to several human genes including FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88A5-88A8; 3-54 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14056945..14087978)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9882667..9913700)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
Title: Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodeling and Xbp1.
FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila.
Title: FOXO-mediated repression of Dicer1 regulates metabolism, stress resistance, and longevity in Drosophila.
Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
Title: Constitutive immune activity promotes JNK- and FoxO-dependent remodeling of Drosophila airways.
Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways.
Title: Differential Dose- and Tissue-Dependent Effects of foxo on Aging, Metabolic and Proteostatic Pathways.
Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.
Title: Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster.
AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections.
Title: AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections.
A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.
Title: A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila.
these data suggest that FOXO temporally regulates olfactory projection neurons cell fate specification
Title: FOXO regulates cell fate specification of Drosophila ventral olfactory projection neurons.
Flies lacking fat body fs(1)h exhibit short lifespan, increased expression of immune target genes, an inability to metabolize triglyceride, and low basal AKT activity, mostly resulting from systemic defects in insulin signalling.
Title: fs(1)h controls metabolic and immune function and enhances survival via AKT and FOXO in Drosophila.
In Drosophila, reduced insulin/IGF signaling extends lifespan by coordinating activation of Aop and Foxo. Aop and Foxo bind the same genomic loci, and individually, they affect similar transcriptional programs in vivo. In combination, Aop can both moderate or synergise with Foxo, dependent on promoter context. Also, Foxo and Aop oppose the gene-regulatory activity of Pnt.
Title: Longevity is determined by ETS transcription factors in multiple tissues and diverse species.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in female germ-line stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lymph gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of fat cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidoglycan recognition protein signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of entry into reproductive diapause	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of octopamine signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of triglyceride catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of growth	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect regulation of hemocyte proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: forkhead box, sub-group O

Names: CG3143-PB; CG3143-PC; CG3143-PF; CG3143-PG; CG3143-PH; dFOXO; forkhead Box O; forkhead bOX-containing protein, subfamily O; forkhead box; forkhead box sub-group O; forkhead box type O; forkhead box, subgroup O; forkhead box-containing protein, O subfamily; forkhead boxO transcription factor; forkhead transcription factor; foxo; foxo-PB; foxo-PC; foxo-PF; foxo-PG; foxo-PH

NP_001303426.1

unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14056945..14087978

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206483.3 → NP_996205.1 forkhead box, sub-group O, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996205.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KF42, Q95TK1, Q95V55, Q9VFN8

Conserved Domains (1) summary

cd00059
Location:95 → 175

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_142073.5 → NP_650330.3 forkhead box, sub-group O, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_650330.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGN1

Conserved Domains (1) summary

cd00059
Location:95 → 175

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001316497.1 → NP_001303426.1 forkhead box, sub-group O, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A126GUT4

Conserved Domains (1) summary

cd00059
Location:95 → 175

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_206482.3 → NP_996204.1 forkhead box, sub-group O, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996204.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7KF42, Q95TK1, Q95V55, Q9VFN8

Conserved Domains (1) summary

cd00059
Location:95 → 175

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
NM_001275628.1 → NP_001262557.1 forkhead box, sub-group O, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262557.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KGN1

Conserved Domains (1) summary

cd00059
Location:95 → 175

FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...