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    Eva1c eva-1 homolog C [ Mus musculus (house mouse) ]

    Gene ID: 70967, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Eva1cprovided by MGI
    Official Full Name
    eva-1 homolog Cprovided by MGI
    Primary source
    MGI:MGI:1918217
    See related
    Ensembl:ENSMUSG00000039903 AllianceGenome:MGI:1918217
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam176c; 1700092M14Rik; 4931408A02Rik
    Summary
    Predicted to enable heparin binding activity. Predicted to be located in plasma membrane. Predicted to colocalize with extracellular region. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human EVA1C (eva-1 homolog C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 10.3), lung adult (RPKM 2.6) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eva1c in Genome Data Viewer
    Location:
    16 C3.3; 16 52.02 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (90623607..90701997)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (90826719..90905109)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene melanocortin 2 receptor accessory protein Neighboring gene STARR-seq mESC enhancer starr_41464 Neighboring gene URB1 ribosome biogenesis 1 homolog (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E1929 Neighboring gene predicted gene, 36363 Neighboring gene STARR-seq mESC enhancer starr_41466 Neighboring gene STARR-seq mESC enhancer starr_41467 Neighboring gene STARR-seq mESC enhancer starr_41468 Neighboring gene predicted gene, 53919 Neighboring gene STARR-positive B cell enhancer ABC_E4188 Neighboring gene cilia and flagella associate protien 298 Neighboring gene synaptojanin 1 Neighboring gene RIKEN cDNA 4930404I05 gene Neighboring gene STARR-positive B cell enhancer mm9_chr16:91012148-91012449

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system. James G, et al. PLoS One, 2013. PMID 24040182, Free PMC Article
    2. EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans. Chan KK, et al. PLoS Genet, 2014 Aug. PMID 25122090, Free PMC Article
    3. From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map. Reymond A, et al. Genomics, 2001 Nov. PMID 11707072
    4. Single-cell transcriptomics of the early developing mouse cerebral cortex disentangle the spatial and temporal components of neuronal fate acquisition. Moreau MX, et al. Development, 2021 Jul 15. PMID 34170322
    5. Regulatory pathway analysis by high-throughput in situ hybridization. Visel A, et al. PLoS Genet, 2007 Oct. PMID 17953485, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we demonstrate that MADD-4 interacts with an EVA-1/UNC-40 co-receptor complex to attract cell extensions
      Title: EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
    2. We report that EVA1C is expressed by axons contributing to commissures, tracts and nerve pathways of the developing spinal cord and forebrain.
      Title: The expression pattern of EVA1C, a novel Slit receptor, is consistent with an axon guidance role in the mouse nervous system.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117713

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    colocalizes_with extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein eva-1 homolog C
    Names
    protein FAM176C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199210.2 → NP_001186139.1  protein eva-1 homolog C isoform 1 precursor

      See identical proteins and their annotated locations for NP_001186139.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC134560, AK016443, AK037486, BC100350
      Consensus CDS
      CCDS57038.1
      UniProtKB/Swiss-Prot
      A2RSZ2, P58659, Q497W3, Q9D4L3
      UniProtKB/TrEMBL
      A0A384DV69
      Related
      ENSMUSP00000036695.8, ENSMUST00000037539.15
      Conserved Domains (2) summary
      pfam02140
      Location:75 → 158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:300 → 440
      FAM176; FAM176 family

    2. NM_001316760.1 → NP_001303689.1  protein eva-1 homolog C isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AC134560, AK016443, AK037486
      Consensus CDS
      CCDS84261.1
      UniProtKB/TrEMBL
      B2RXT2
      Related
      ENSMUST00000232665.2
      Conserved Domains (2) summary
      pfam02140
      Location:81 → 164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:205 → 345
      FAM176; FAM176 family

    3. NM_001316761.1 → NP_001303690.1  protein eva-1 homolog C isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC134560, AK016443, AK037486
      Consensus CDS
      CCDS88968.1
      UniProtKB/TrEMBL
      A0A338P750, B2RXT2
      Related
      ENSMUSP00000156225.2, ENSMUST00000231280.2
      Conserved Domains (2) summary
      pfam02140
      Location:69 → 152
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:193 → 333
      FAM176; FAM176 family

    4. NM_027627.3 → NP_081903.1  protein eva-1 homolog C isoform 2

      See identical proteins and their annotated locations for NP_081903.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC134560, AK037486, BC100350
      Consensus CDS
      CCDS28319.1
      UniProtKB/Swiss-Prot
      P58659
      UniProtKB/TrEMBL
      Q8CAX0
      Related
      ENSMUSP00000097141.4, ENSMUST00000099543.10
      Conserved Domains (2) summary
      pfam02140
      Location:75 → 158
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:252 → 392
      FAM176; FAM176 family

    RNA

    1. NR_133572.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC134560, AK037486
      Related
      ENSMUST00000130868.8

    2. NR_133573.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
      Source sequence(s)
      AC134560, AK016443, AK037486
      Related
      ENSMUST00000152223.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      90623607..90701997
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317131.1 → XP_017172620.1  protein eva-1 homolog C isoform X2

      UniProtKB/TrEMBL
      B2RXT2
      Conserved Domains (2) summary
      pfam02140
      Location:81 → 164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:205 → 345
      FAM176; FAM176 family

    2. XM_006523085.5 → XP_006523148.1  protein eva-1 homolog C isoform X1

      UniProtKB/TrEMBL
      A0A384DV69
      Conserved Domains (2) summary
      pfam02140
      Location:75 → 157
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:299 → 439
      FAM176; FAM176 family

    3. XM_030249282.2 → XP_030105142.1  protein eva-1 homolog C isoform X3

      UniProtKB/TrEMBL
      B2RXT2
      Conserved Domains (1) summary
      pfam14851
      Location:145 → 285
      FAM176; FAM176 family

    4. XM_017317132.1 → XP_017172621.1  protein eva-1 homolog C isoform X2

      UniProtKB/TrEMBL
      B2RXT2
      Conserved Domains (2) summary
      pfam02140
      Location:81 → 164
      Gal_Lectin; Galactose binding lectin domain
      pfam14851
      Location:205 → 345
      FAM176; FAM176 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58659.2 GenPept UniProtKB/Swiss-Prot:P58659

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