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    Scnn1g sodium channel, nonvoltage-gated 1 gamma [ Mus musculus (house mouse) ]

    Gene ID: 20278, updated on 27-Nov-2024

    Summary

    Official Symbol
    Scnn1gprovided by MGI
    Official Full Name
    sodium channel, nonvoltage-gated 1 gammaprovided by MGI
    Primary source
    MGI:MGI:104695
    See related
    Ensembl:ENSMUSG00000000216 AllianceGenome:MGI:104695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCNEG
    Summary
    This gene encodes the gamma subunit of the epithelial sodium channel, a member of the amiloride-sensitive sodium channel family of proteins. This channel regulates sodium homeostasis and blood pressure, by controlling sodium transport in the kidney, colon and lung. Proteolytic processing of the encoded protein results in the release of an inhibitory peptide and channel activation. Homozygous knockout mice for this gene exhibit perinatal lethality, likely due to excess serum potassium. [provided by RefSeq, Oct 2015]
    Expression
    Biased expression in lung adult (RPKM 55.1), kidney adult (RPKM 20.3) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Scnn1g in Genome Data Viewer
    Location:
    7 F2; 7 65.07 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (121333643..121367705)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (121734420..121768482)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene heparan sulfate (glucosamine) 3-O-sulfotransferase 2 Neighboring gene RIKEN cDNA 1700025J12 gene Neighboring gene STARR-positive B cell enhancer ABC_E10470 Neighboring gene ubiquitin specific peptidase 31 Neighboring gene STARR-positive B cell enhancer ABC_E6594 Neighboring gene STARR-positive B cell enhancer ABC_E8205 Neighboring gene STARR-seq mESC enhancer starr_20066 Neighboring gene STARR-seq mESC enhancer starr_20067 Neighboring gene predicted gene, 36848 Neighboring gene STARR-seq mESC enhancer starr_20068 Neighboring gene sodium channel, nonvoltage-gated 1 beta Neighboring gene STARR-seq mESC enhancer starr_20069 Neighboring gene component of oligomeric golgi complex 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular response to acidic pH IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to acidic pH ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to aldosterone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to aldosterone NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to vasopressin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular sodium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in intracellular sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organismal-level water homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in multicellular organismal-level water homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of blood pressure NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of salty taste NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sensory perception of sour taste NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in sodium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sodium ion import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sodium ion import across plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sodium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within sodium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within sodium ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of sodium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of sodium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sodium channel complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of sodium channel complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    amiloride-sensitive sodium channel subunit gamma
    Names
    ENaC gamma
    epithelial Na(+) channel subunit gamma
    gamma-ENaC
    gamma-NaCH
    nonvoltage-gated sodium channel 1 subunit gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011326.3NP_035456.1  amiloride-sensitive sodium channel subunit gamma

      See identical proteins and their annotated locations for NP_035456.1

      Status: REVIEWED

      Source sequence(s)
      AC165081, AF112187, BP767443
      Consensus CDS
      CCDS21803.1
      UniProtKB/Swiss-Prot
      Q9WU39
      UniProtKB/TrEMBL
      Q3UNU3
      Related
      ENSMUSP00000000221.6, ENSMUST00000000221.6
      Conserved Domains (2) summary
      TIGR00859
      Location:24636
      ENaC; sodium channel transporter
      TIGR00867
      Location:32557
      deg-1; degenerin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      121333643..121367705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507477.4XP_006507540.1  amiloride-sensitive sodium channel subunit gamma isoform X1

      UniProtKB/TrEMBL
      Q3UNU3
      Conserved Domains (1) summary
      TIGR00859
      Location:2489
      ENaC; sodium channel transporter