U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Kif12 kinesin family member 12 [ Mus musculus (house mouse) ]

    Gene ID: 16552, updated on 27-Nov-2024

    Summary

    Official Symbol
    Kif12provided by MGI
    Official Full Name
    kinesin family member 12provided by MGI
    Primary source
    MGI:MGI:1098232
    See related
    Ensembl:ENSMUSG00000028357 AllianceGenome:MGI:1098232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Located in microtubule organizing center. Is expressed in embryo and inner cell mass. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human KIF12 (kinesin family member 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney adult (RPKM 61.1), colon adult (RPKM 9.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Kif12 in Genome Data Viewer
    Location:
    4 B3; 4 33.96 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63076185..63090382, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63157948..63172145, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene predicted gene, 30764 Neighboring gene alpha 1 microglobulin/bikunin precursor Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62883492-62883675 Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:62968523-62968632 Neighboring gene STARR-seq mESC enhancer starr_10435 Neighboring gene predicted gene, 52743

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF12
    Names
    N-9 kinesin
    kinesin 12
    kinesin superfamily protein 12

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317352.1NP_001304281.1  kinesin-like protein KIF12 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL691496
      Consensus CDS
      CCDS89761.1
      UniProtKB/TrEMBL
      A0A097ZP89, A0A1Y7VK29
      Related
      ENSMUSP00000152690.2, ENSMUST00000156618.9
      Conserved Domains (3) summary
      cd00106
      Location:25358
      KISc; Kinesin motor domain
      pfam00225
      Location:31360
      Kinesin; Kinesin motor domain
      pfam12711
      Location:379464
      Kinesin-relat_1; Kinesin motor
    2. NM_010616.3NP_034746.1  kinesin-like protein KIF12 isoform 2

      See identical proteins and their annotated locations for NP_034746.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK018598, BP765257
      Consensus CDS
      CCDS18249.1
      UniProtKB/Swiss-Prot
      O35061, Q9D2Z8
      UniProtKB/TrEMBL
      A0A097ZP89
      Related
      ENSMUSP00000030042.3, ENSMUST00000030042.3
      Conserved Domains (3) summary
      cd00106
      Location:25358
      KISc; Kinesin motor domain
      pfam00225
      Location:31360
      Kinesin; Kinesin motor domain
      pfam12711
      Location:379464
      Kinesin-relat_1; Kinesin motor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63076185..63090382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017319998.3XP_017175487.1  kinesin-like protein KIF12 isoform X1

      UniProtKB/TrEMBL
      A0A097ZP89
      Conserved Domains (1) summary
      cd00106
      Location:25358
      KISc; Kinesin motor domain
    2. XM_017319999.3XP_017175488.1  kinesin-like protein KIF12 isoform X2

      UniProtKB/TrEMBL
      A0A097ZP89
      Conserved Domains (1) summary
      cd00106
      Location:25358
      KISc; Kinesin motor domain
    3. XM_017320000.2XP_017175489.1  kinesin-like protein KIF12 isoform X3

      Conserved Domains (1) summary
      cd00106
      Location:25358
      KISc; Kinesin motor domain