Car3 carbonic anhydrase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Car3provided by RGD
Official Full Name: carbonic anhydrase 3provided by RGD
Primary source: RGD:2241
See related: EnsemblRapid:ENSRNOG00000010079 AllianceGenome:RGD:2241
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ca3
Summary: Enables phosphatase activity. Involved in response to ethanol and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human CA3 (carbonic anhydrase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 11846.3), Liver (RPKM 3098.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (88491666..88501299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (86770418..86780011, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (88126519..88136063, complement)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation.
Title: Carbonic anhydrase 3 increases during liver adipogenesis even in pre-obesity, and its inhibitors reduce liver adipose accumulation.
Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line.
Title: Carbonic Anhydrase III Attenuates Hypoxia-Induced Apoptosis and Activates PI3K/Akt/mTOR Pathway in H9c2 Cardiomyocyte Cell Line.
these data clearly suggests that CAIII serves as an important antioxidant critical in protecting NP cells against oxidative stress-induced injury.
Title: Expression of Carbonic Anhydrase III, a Nucleus Pulposus Phenotypic Marker, is Hypoxia-responsive and Confers Protection from Oxidative Stress-induced Cell Death.
These results indicated that, following denervation, changes in the expression of CAIII were associated with myofiber remodeling. Specifically, the change in the expression of CAIII reflected the conversion to type I myofibers, suggesting the importance of CAIII in resistance to fatigue in skeletal muscle.
Title: Expression of carbonic anhydrase III and skeletal muscle remodeling following selective denervation.
The results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury.
Title: Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury.
CA-III expression is down-regulated in the liver of chronically alcohol-fed rats.
Title: Combined proteomic analysis of liver tissue and serum in chronically alcohol-fed rats.
Suppression of carbonic anhydrase III (CAIII) accompanied hepatocarcinogenesis and it is a secondary consequence of the high copper levels in the liver.
Title: Sexual dimorphism in LEC rat liver: suppression of carbonic anhydrase III by copper accumulation during hepatocarcinogenesis.
Evi1 represses transcription of caIII gene expression, leading to increased sensitivity to H(2)O(2)-induced apoptosis
Title: Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III.
Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Title: Carbonic anhydrase III and four-and-a-half LIM protein 1 are preferentially oxidized with muscle unloading.
Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes
Title: Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes; an immunocytochemical study.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Car3 (e-PCR), detects polymorphism
- UniSTS:506772

RH129349 (e-PCR)
- UniSTS:212656

RH127589 (e-PCR)
- UniSTS:210899

UniSTS:498421 (e-PCR)
- UniSTS:498421

Car3 (e-PCR), detects polymorphism
- UniSTS:498421

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables carbonate dehydratase activity	ISO Inferred from Sequence Orthology more info
enables carbonate dehydratase activity	TAS Traceable Author Statement more info	PubMed
enables nickel cation binding	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	ISO Inferred from Sequence Orthology more info
enables phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbonic anhydrase 3

Names: CA-III; carbonate dehydratase III; carbonic anhydrase III

NP_062165.2

EC 4.2.1.1

XP_006232178.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019292.4 → NP_062165.2 carbonic anhydrase 3

See identical proteins and their annotated locations for NP_062165.2

Status: PROVISIONAL

Source sequence(s)

AB030830

UniProtKB/Swiss-Prot

O54961, P14141, Q9QV77

UniProtKB/TrEMBL

A0A8L2Q6S9, A6IH11

Related

ENSRNOP00000014177.5, ENSRNOT00000014180.8

Conserved Domains (1) summary

cd03119
Location:1 → 259

alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

88491666..88501299 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232116.3 → XP_006232178.1 carbonic anhydrase 3 isoform X1

See identical proteins and their annotated locations for XP_006232178.1

UniProtKB/Swiss-Prot

O54961, P14141, Q9QV77

UniProtKB/TrEMBL

A0A8L2Q6S9, A6IH11

Conserved Domains (1) summary

cd03119
Location:1 → 259

alpha_CA_I_II_III_XIII; Carbonic anhydrase alpha, isozymes I, II, and III and XIII. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on ...