Slc24a1 solute carrier family 24 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc24a1provided by RGD
Official Full Name: solute carrier family 24 member 1provided by RGD
Primary source: RGD:620080
See related: EnsemblRapid:ENSRNOG00000052051 AllianceGenome:RGD:620080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nckx1
Summary: Predicted to enable calcium channel activity and calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport. Located in cell surface. Human ortholog(s) of this gene implicated in congenital stationary night blindness 1D. Orthologous to human SLC24A1 (solute carrier family 24 member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 6.1), Brain (RPKM 2.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (74334556..74361313, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (65440842..65466001, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (70409683..70438352, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential expression in the rat brain
Title: Differential expression of Na/Ca exchanger and Na/Ca + K exchanger transcripts in rat brain.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium, potassium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in long-term synaptic depression	IBA Inferred from Biological aspect of Ancestor more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium/calcium exchanger 1

Names: Na(+)/K(+)/Ca(2+)-exchange protein 1; retinal Na/Ca,K exchanger; retinal rod Na-Ca+K exchanger; sodium/calcium/potassium exchanger; solute carrier family 24 (sodium/potassium/calcium exchanger), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_020090.1 → NP_064475.1 sodium/potassium/calcium exchanger 1

See identical proteins and their annotated locations for NP_064475.1

Status: PROVISIONAL

Source sequence(s)

AF176688

UniProtKB/Swiss-Prot

Q62932, Q9QZM6

UniProtKB/TrEMBL

A0A0G2K8E1

Related

ENSRNOP00000074571.2, ENSRNOT00000077152.3

Conserved Domains (4) summary

TIGR00927
Location:1 → 1181

2A1904; K+-dependent Na+/Ca+ exchanger

pfam01699
Location:1018 → 1169

Na_Ca_ex; Sodium/calcium exchanger protein

pfam03247
Location:837 → 918

Prothymosin; Prothymosin/parathymosin family

cl22451
Location:746 → 866

ASF1_hist_chap; ASF1 like histone chaperone