Klk1b5 kallikrein 1-related peptidase b5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klk1b5provided by MGI
Official Full Name: kallikrein 1-related peptidase b5provided by MGI
Primary source: MGI:MGI:892020
See related: Ensembl:ENSMUSG00000066512 AllianceGenome:MGI:892020
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Klk5; mGK-5; kallikrein
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
Expression: Biased expression in colon adult (RPKM 532.5), kidney adult (RPKM 433.1) and 4 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43865898..43870127)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44216474..44220703)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice.
Title: Deletion of kallikrein 1b5 (Klk1b5) has no impact on fertility in mice.
Data support a completely novel mechanism in which miR-382 targets kallikrein 5 and contributes to the development of renal inner medullary interstitial fibrosis.
Title: MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

General gene information

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Markers

Klk1b5 (e-PCR), detects polymorphism
- UniSTS:164691

Klk5 (e-PCR), detects polymorphism
- UniSTS:143703

Ngfa (e-PCR), detects polymorphism
- UniSTS:144010

Klk1b5 (e-PCR), detects polymorphism
- UniSTS:507383

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	ISM Inferred from Sequence Model more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type peptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in zymogen activation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kallikrein 1-related peptidase b5

Names: glandular kallikrein K5; tissue kallikrein-5

NP_032482.1

EC 3.4.21.35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008456.4 → NP_032482.1 kallikrein 1-related peptidase b5 preproprotein

See identical proteins and their annotated locations for NP_032482.1

Status: REVIEWED

Source sequence(s)

AC124176

Consensus CDS

CCDS21201.1

UniProtKB/Swiss-Prot

P15945, Q52KM1, Q565D7

UniProtKB/TrEMBL

A0A1R3UCI2

Related

ENSMUSP00000073964.3, ENSMUST00000074359.4

Conserved Domains (2) summary

smart00020
Location:24 → 253

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:25 → 256

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...