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    NPY1R neuropeptide Y receptor Y1 [ Homo sapiens (human) ]

    Gene ID: 4886, updated on 10-Dec-2024

    Summary

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    Official Symbol
    NPY1Rprovided by HGNC
    Official Full Name
    neuropeptide Y receptor Y1provided by HGNC
    Primary source
    HGNC:HGNC:7956
    See related
    Ensembl:ENSG00000164128 MIM:162641; AllianceGenome:HGNC:7956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NPYR; NPY1-R
    Summary
    This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in spleen (RPKM 33.6), fat (RPKM 10.5) and 9 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See NPY1R in Genome Data Viewer
    Location:
    4q32.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (163323962..163344689, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (166671793..166692717, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (164245114..164253748, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_75696 Neighboring gene mitochondrial ribosomal protein S5 pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:164238175-164238759 Neighboring gene neuropeptide Y receptor Y5 Neighboring gene ribosomal protein L35a pseudogene 12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:164336685-164337439 Neighboring gene transketolase like 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A case of autism with an interstitial deletion on 4q leading to hemizygosity for genes encoding for glutamine and glycine neurotransmitter receptor sub-units (AMPA 2, GLRA3, GLRB) and neuropeptide receptors NPY1R, NPY5R. Ramanathan S, et al. BMC Med Genet, 2004 Apr 16. PMID 15090072, Free PMC Article
    2. Characterization of an interstitial 4q32 deletion in a patient with mental retardation and a complex chromosome rearrangement. Tzschach A, et al. Am J Med Genet A, 2010 Apr. PMID 20358617
    3. [Lys(DOTA)4]BVD15, a novel and potent neuropeptide Y analog designed for Y1 receptor-targeted breast tumor imaging. Guérin B, et al. Bioorg Med Chem Lett, 2010 Feb 1. PMID 20042335
    4. Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. Wang L, et al. J Am Coll Cardiol, 2009 Sep 1. PMID 19712806, Free PMC Article
    5. Contribution of a tyrosine-based motif to cellular trafficking of wild-type and truncated NPY Y(1) receptors. Lecat S, et al. Cell Signal, 2011 Jan. PMID 20837140

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
      Title: Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity.
    2. Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
      Title: Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation.
    3. NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
      Title: NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer.
    4. Structural basis of neuropeptide Y signaling through Y1 receptor.
      Title: Structural basis of neuropeptide Y signaling through Y1 receptor.
    5. Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
      Title: Theoretical study of the interactions between peptide tyrosine tyrosine [PYY (1-36)], a newly identified modulator in type 2 diabetes pathophysiology, with receptors NPY1R and NPY4R.
    6. Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
      Title: Differential regulation of NPY and SP receptor expression in STRO-1+ve PDLSCs by inflammatory cytokines.
    7. Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
      Title: Clinical Significance of Immunohistochemical Expression of Neuropeptide Y1 Receptor in Patients With Breast Cancer in Egypt.
    8. Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
      Title: Further evidence for the association of GAL, GALR1 and NPY1R variants with opioid dependence.
    9. Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
      Title: Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer.
    10. the current review aims to compile, evaluate and summarise current knowledge on PYY, with particular emphasis on obesity and diabetes treatment, and the importance of specific Y receptor interactions for this.
      Title: Emerging therapeutic potential for peptide YY for obesity-diabetes.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables neuropeptide Y receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables neuropeptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neuropeptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pancreatic polypeptide receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide YY receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in feeding behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in locomotory behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of blood pressure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of pain IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    neuropeptide Y receptor type 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000909.6 → NP_000900.1  neuropeptide Y receptor type 1

      See identical proteins and their annotated locations for NP_000900.1

      Status: VALIDATED

      Source sequence(s)
      AC079238, BC036657
      Consensus CDS
      CCDS34089.1
      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Related
      ENSP00000354652.2, ENST00000296533.3
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52 → 176
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      163323962..163344689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263031.5 → XP_005263088.1  neuropeptide Y receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_005263088.1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52 → 176
      7tm_4; Olfactory receptor

    2. XM_011532010.4 → XP_011530312.1  neuropeptide Y receptor type 1 isoform X1

      See identical proteins and their annotated locations for XP_011530312.1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
      Conserved Domains (2) summary
      pfam00001
      Location:57 → 320
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:52 → 176
      7tm_4; Olfactory receptor

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      166671793..166692717 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350119.1 → XP_054206094.1  neuropeptide Y receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929

    2. XM_054350120.1 → XP_054206095.1  neuropeptide Y receptor type 1 isoform X1

      UniProtKB/Swiss-Prot
      B2R6H5, P25929
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25929.1 GenPept UniProtKB/Swiss-Prot:P25929

    Gene LinkOut

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