U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from OMIM

    • Showing Current items.

    PCSK6 proprotein convertase subtilisin/kexin type 6 [ Homo sapiens (human) ]

    Gene ID: 5046, updated on 10-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PCSK6provided by HGNC
    Official Full Name
    proprotein convertase subtilisin/kexin type 6provided by HGNC
    Primary source
    HGNC:HGNC:8569
    See related
    Ensembl:ENSG00000140479 MIM:167405; AllianceGenome:HGNC:8569
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPC4; PACE4
    Summary
    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]
    Expression
    Biased expression in spleen (RPKM 31.3), liver (RPKM 30.7) and 12 other tissues See more
    Orthologs
    mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PCSK6 in Genome Data Viewer
    Location:
    15q26.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (101303933..101489707, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (99058998..99244970, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (101844138..102029910, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6888 Neighboring gene selenoprotein S Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101834407-101835038 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10193 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10194 Neighboring gene small nuclear ribonucleoprotein polypeptide A' Neighboring gene SNRPA1 divergent transcript Neighboring gene uncharacterized LOC100507472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101866838-101867338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6890 Neighboring gene PCSK6 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101897421-101898364 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101899309-101900252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101900253-101901196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101903043-101903860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101910467-101910968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101910969-101911468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101926563-101927064 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:101927065-101927564 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101951801-101952617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:101966524-101967114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:101991219-101991952 Neighboring gene Sharpr-MPRA regulatory region 2389 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:101996796-101996999 Neighboring gene uncharacterized LOC124903566 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr15:102009487-102010686 Neighboring gene uncharacterized LOC107987228 Neighboring gene uncharacterized LOC124903567

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors. Bakrania A, et al. Can J Physiol Pharmacol, 2020 Jul. PMID 32119574
    2. Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis. Wang F, et al. J Rheumatol, 2015 Feb. PMID 25433529
    3. Multi-Leu PACE4 Inhibitor Retention within Cells Is PACE4 Dependent and a Prerequisite for Antiproliferative Activity. Couture F, et al. Biomed Res Int, 2015. PMID 26114115, Free PMC Article
    4. PCSK6 regulated by LH inhibits the apoptosis of human granulosa cells via activin A and TGFβ2. Wang Y, et al. J Endocrinol, 2014 Jul. PMID 24860148
    5. Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis. Perisic L, et al. Arterioscler Thromb Vasc Biol, 2013 Oct. PMID 23908247

    See all (102) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation.
      Title: PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation.
    2. PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
      Title: PCSK6 and Survival in Idiopathic Pulmonary Fibrosis.
    3. PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer.
      Title: PACE4-altCT isoform of proprotein convertase PACE4 as tissue and plasmatic biomarker for prostate cancer.
    4. Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome.
      Title: Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome.
    5. Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis.
      Title: Up-regulation of PCSK6 by lipid oxidation products: A possible role in atherosclerosis.
    6. Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
      Title: Paired Basic Amino Acid-cleaving Enzyme 4 (PCSK6): An Emerging New Target Molecule in Human Melanoma.
    7. Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors.
      Title: Upregulation of PACE4 in prostate cancer is not dependent on E2F transcription factors.
    8. PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.
      Title: PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.
    9. PCSK6, a gene that has been implicated in the ontogenesis of bodily asymmetries by regulating the nodal cascade, is also relevant for structural asymmetries in the human brain.
      Title: Structural Asymmetry in the Frontal and Temporal Lobes Is Associated with PCSK6 VNTR Polymorphism.
    10. Data suggest that soluble corin lacking transmembrane domain is activated by PCSK6 in conditioned medium or in cell-free system but not intracellularly; cell membrane association is unnecessary for PCSK6 to activate corin; soluble corin and PCSK6 are secreted by cardiomyocytes (or HEK293 cells) via different intracellular pathways. (PCSK6 = proprotein convertase subtilisin/kexin type-6)
      Title: Functional analysis of corin protein domains required for PCSK6-mediated activation.
    Submit: New GeneRIF Correction See all GeneRIFs (40)

    Phenotypes

    Go to the top of the page Help

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog
    PCSK6 is associated with handedness in individuals with dyslexia.
    EBI GWAS Catalog

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

    Go to the top of the page Help

    Replication interactions

    Interaction Pubs
    Knockdown of proprotein convertase subtilisin/kexin type 6 (PCSK6) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Kexin/subtilisin-related convertases such as furin, PACE4, PC1, PC2, PC5 and its isoform PC5/6-B can process HIV-1 gp160 to gp120/gp41 PubMed
    Vpr vpr Vpr processing by soluble PCSK6 (PACE4) DOES NOT involve PAR1 PubMed
    vpr soluble PCSK6 (PACE4) cleaves Vpr PubMed
    vpr Proprotein convertase PC5 cleaves extracellular HIV-1 Vpr between amino-acids 88-89 located within the functionally important C-terminal arginine-rich domain RQRR(88)V/A/G(89)R in Vpr PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endopeptidase activity TAS
    Traceable Author Statement
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nerve growth factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycoprotein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nerve growth factor production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptide hormone processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptide hormone processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in plasma lipoprotein particle remodeling TAS
    Traceable Author Statement
    more info
    		  
    involved_in protein processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of BMP signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in secretion by cell IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in zygotic determination of anterior/posterior axis, embryo IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    proprotein convertase subtilisin/kexin type 6
    Names
    paired basic amino acid cleaving enzyme 4
    paired basic amino acid cleaving system 4
    subtilisin-like proprotein convertase 4
    subtilisin/kexin-like protease PACE4
    NP_001278238.1
    NP_002561.1
    NP_612192.1
    NP_612195.1
    NP_612196.1
    NP_612197.1
    NP_612198.2

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030047.4 RefSeqGene

      Range
      40496..226270
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_888

    mRNA and Protein(s)

    1. NM_001291309.2 → NP_001278238.1  proprotein convertase subtilisin/kexin type 6 isoform i preproprotein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks two consecutive exons in the central coding region but maintains reading frame, compared to variant 1. The encoded isoform (i) is shorter, compared to isoform PACE4-AI.
      Source sequence(s)
      AB208955, AM491522, BU732171, DB143095, M80482
      UniProtKB/TrEMBL
      Q59H04
      Related
      ENSP00000381246.2, ENST00000398185.6
      Conserved Domains (7) summary
      cd04059
      Location:160 → 436
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:770 → 812
      FU; Furin-like repeats
      cd00064
      Location:725 → 771
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam01483
      Location:465 → 555
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:868 → 891
      PLAC; PLAC (protease and lacunin) domain
      pfam14843
      Location:620 → 730
      GF_recep_IV; Growth factor receptor domain IV
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    2. NM_002570.5 → NP_002561.1  proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein

      See identical proteins and their annotated locations for NP_002561.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the predominant isoform (PACE4-AI, also known as PACE4 and PACE4-A).
      Source sequence(s)
      AL545278, AM491522, BU732171, BX428035, M80482
      Consensus CDS
      CCDS73790.1
      UniProtKB/Swiss-Prot
      P29122, Q15099, Q15100, Q9UEG7, Q9UEJ1, Q9UEJ2, Q9UEJ7, Q9UEJ8, Q9UEJ9, Q9Y4G9, Q9Y4H0, Q9Y4H1
      UniProtKB/TrEMBL
      A0A087WY68
      Related
      ENSP00000482760.1, ENST00000611716.5
      Conserved Domains (8) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:743 → 789
      FU; Furin-like repeats
      cd00064
      Location:799 → 845
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:196 → 479
      Peptidase_S8; Subtilase family
      pfam01483
      Location:539 → 629
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:942 → 965
      PLAC; PLAC (protease and lacunin) domain
      pfam15913
      Location:751 → 847
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    3. NM_138319.4 → NP_612192.1  proprotein convertase subtilisin/kexin type 6 isoform PACE4-AII preproprotein

      See identical proteins and their annotated locations for NP_612192.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (PACE4-AII) is shorter but maintains the same reading frame, compared to isoform PACE4-AI.
      Source sequence(s)
      AL545278, AM491522, BU732171, BX428035, M80482
      Consensus CDS
      CCDS73789.1
      UniProtKB/TrEMBL
      A0A087WZR0
      Related
      ENSP00000479496.1, ENST00000618548.4
      Conserved Domains (8) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      smart00261
      Location:730 → 776
      FU; Furin-like repeats
      cd00064
      Location:786 → 832
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00082
      Location:196 → 479
      Peptidase_S8; Subtilase family
      pfam01483
      Location:539 → 629
      P_proprotein; Proprotein convertase P-domain
      pfam08686
      Location:929 → 952
      PLAC; PLAC (protease and lacunin) domain
      pfam15913
      Location:738 → 834
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    4. NM_138322.4 → NP_612195.1  proprotein convertase subtilisin/kexin type 6 isoform PACE4B preproprotein

      See identical proteins and their annotated locations for NP_612195.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, one of which is a frameshift, compared to variant 1. The encoded isoform PACE4B (also known as PACE4.1) has a distinct C-terminus compared to isoform PACE4-AI. This isoform is thought to be catalytically inactive.
      Source sequence(s)
      AC087528, AM491522, HY122769, M80482
      UniProtKB/Swiss-Prot
      P29122
      UniProtKB/TrEMBL
      A2RQD9
      Conserved Domains (3) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:196 → 455
      Peptidase_S8; Subtilase family
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    5. NM_138323.3 → NP_612196.1  proprotein convertase subtilisin/kexin type 6 isoform PACE4CS preproprotein

      See identical proteins and their annotated locations for NP_612196.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate exon in the 3' coding region and lacks several downstream exons when compared to variant 1. These differences cause a frameshift and thus isoform PACE4CS has a distinct C-terminus compared to isoform PACE4-AI.
      Source sequence(s)
      AC023024, AL545278, AM491522, BX428035, D28513, M80482
      Consensus CDS
      CCDS73791.1
      UniProtKB/TrEMBL
      H0YKZ4
      Related
      ENSP00000478081.1, ENST00000615296.4
      Conserved Domains (4) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:196 → 455
      Peptidase_S8; Subtilase family
      pfam01483
      Location:539 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    6. NM_138324.3 → NP_612197.1  proprotein convertase subtilisin/kexin type 6 isoform PACE4C preproprotein

      See identical proteins and their annotated locations for NP_612197.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses two alternate exons in the 3' coding region and lacks several downstream exons when compared to variant 1. These differences cause a frameshift and thus isoform PACE4C has a distinct C-terminus compared to isoform PACE4-AI.
      Source sequence(s)
      AC023024, AL545278, AM491522, BX428035, D28513, M80482
      Consensus CDS
      CCDS73793.1
      UniProtKB/TrEMBL
      H0YKZ4
      Related
      ENSP00000477768.1, ENST00000611967.4
      Conserved Domains (4) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:196 → 479
      Peptidase_S8; Subtilase family
      pfam01483
      Location:539 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    7. NM_138325.4 → NP_612198.2  proprotein convertase subtilisin/kexin type 6 isoform f preproprotein

      See identical proteins and their annotated locations for NP_612198.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks multiple 3' exons and uses an alternate 3' terminal exon, compared to variant 1. This results in a shorter isoform (f) that has a distinct C-terminus, compared to isoform PACE4-AI.
      Source sequence(s)
      AC023024, AL545278, AM491522, BX428035, D28514, HY205376, M80482
      Consensus CDS
      CCDS73792.1
      UniProtKB/TrEMBL
      H0YKZ4, H7BXT3
      Related
      ENSP00000332052.8, ENST00000331826.12
      Conserved Domains (4) summary
      cd04059
      Location:160 → 454
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:196 → 479
      Peptidase_S8; Subtilase family
      pfam01483
      Location:539 → 623
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:73 → 149
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      101303933..101489707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      99058998..99244970 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_138320.1: Suppressed sequence

      Description
      NM_138320.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    2. NM_138321.1: Suppressed sequence

      Description
      NM_138321.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29122.1 GenPept UniProtKB/Swiss-Prot:P29122

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous