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    PAM peptidylglycine alpha-amidating monooxygenase [ Homo sapiens (human) ]

    Gene ID: 5066, updated on 3-Dec-2024

    Summary

    Official Symbol
    PAMprovided by HGNC
    Official Full Name
    peptidylglycine alpha-amidating monooxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:8596
    See related
    Ensembl:ENSG00000145730 MIM:170270; AllianceGenome:HGNC:8596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PAL; PHM; PAM-1
    Summary
    This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
    Expression
    Broad expression in heart (RPKM 269.6), adrenal (RPKM 54.3) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PAM in Genome Data Viewer
    Location:
    5q21.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (102754783..103031105)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (103262795..103539139)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (102090487..102366809)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 492 Neighboring gene long intergenic non-protein coding RNA 491 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:101996845-101997345 Neighboring gene VISTA enhancer hs1649 Neighboring gene uncharacterized LOC105379104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16207 Neighboring gene NANOG hESC enhancer GRCh37_chr5:102085276-102085842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:102090038-102090563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16208 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:102091571-102092071 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16209 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:102363594-102364793 Neighboring gene Sharpr-MPRA regulatory region 7406 Neighboring gene uncharacterized LOC105379105 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables copper ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidylamidoglycolate lyase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables peptidylamidoglycolate lyase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidylglycine monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidylglycine monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
     
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid primary amide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide amidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to zinc ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    located_in secretory granule membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidyl-glycine alpha-amidating monooxygenase
    Names
    pancreatic peptidylglycine alpha-amidating monooxygenase
    peptidyl alpha-amidating enzyme
    peptidyl-alpha-hydroxyglycine alpha-amidating lyase
    peptidylamidoglycolate lyase
    peptidylglycine 2-hydroxylase
    peptidylglycine alpha-hydroxylating monooxygenase
    NP_000910.2
    NP_001170777.1
    NP_001306872.1
    NP_001351511.1
    NP_001351512.1
    NP_001351513.1
    NP_001351514.1
    NP_001351515.1
    NP_001351516.1
    NP_001351517.1
    NP_001351518.1
    NP_001351519.1
    NP_001351520.1
    NP_001351521.1
    NP_001351522.1
    NP_001351523.1
    NP_620121.1
    NP_620176.1
    NP_620177.1
    XP_011541721.1
    XP_016864984.1
    XP_016864985.1
    XP_016864986.1
    XP_016864991.1
    XP_016864994.1
    XP_016864996.1
    XP_016865000.1
    XP_024301834.1
    XP_024301837.1
    XP_024301838.1
    XP_024301840.1
    XP_024301842.1
    XP_024301843.1
    XP_024301844.1
    XP_024301846.1
    XP_024301848.1
    XP_024301849.1
    XP_024301852.1
    XP_024301853.1
    XP_047273196.1
    XP_047273197.1
    XP_047273198.1
    XP_047273199.1
    XP_047273200.1
    XP_047273201.1
    XP_047273202.1
    XP_047273203.1
    XP_047273204.1
    XP_047273205.1
    XP_047273206.1
    XP_047273207.1
    XP_047273208.1
    XP_047273209.1
    XP_047273210.1
    XP_047273211.1
    XP_047273212.1
    XP_054208643.1
    XP_054208644.1
    XP_054208645.1
    XP_054208646.1
    XP_054208647.1
    XP_054208648.1
    XP_054208649.1
    XP_054208650.1
    XP_054208651.1
    XP_054208652.1
    XP_054208653.1
    XP_054208654.1
    XP_054208655.1
    XP_054208656.1
    XP_054208657.1
    XP_054208658.1
    XP_054208659.1
    XP_054208660.1
    XP_054208661.1
    XP_054208662.1
    XP_054208663.1
    XP_054208664.1
    XP_054208665.1
    XP_054208666.1
    XP_054208667.1
    XP_054208668.1
    XP_054208669.1
    XP_054208670.1
    XP_054208671.1
    XP_054208672.1
    XP_054208673.1
    XP_054208674.1
    XP_054208675.1
    XP_054208676.1
    XP_054208677.1
    XP_054208678.1
    XP_054208679.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029444.2 RefSeqGene

      Range
      5523..279934
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000919.4NP_000910.2  peptidyl-glycine alpha-amidating monooxygenase isoform a precursor

      See identical proteins and their annotated locations for NP_000910.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region compared to variant 5. The encoded isoform (a) is longer than isoform e. This isoform (a) may undergo proteolytic processing similar to isoform e.
      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS43348.1
      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000507038.1, ENST00000684529.1
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. NM_001177306.2NP_001170777.1  peptidyl-glycine alpha-amidating monooxygenase isoform e preproprotein

      See identical proteins and their annotated locations for NP_001170777.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes isoform e.
      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS54885.1
      UniProtKB/Swiss-Prot
      A6NMR0, A8K293, O43211, O95080, P19021, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0
      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000396493.3, ENST00000438793.8
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    3. NM_001319943.1NP_001306872.1  peptidyl-glycine alpha-amidating monooxygenase isoform f precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and contains an alternate in-frame exon in its central coding region compared to variant 5. The encoded isoform (f) is longer than isoform e and may undergo proteolytic processing similar to isoform e.
      Source sequence(s)
      AB095007, AC010250, BI966687, DA240822, DA406933, U19966
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    4. NM_001364582.2NP_001351511.1  peptidyl-glycine alpha-amidating monooxygenase isoform g precursor

      Status: REVIEWED

      Source sequence(s)
      AC008779, AC010250, AC113373
      Consensus CDS
      CCDS93753.1
      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000506966.1, ENST00000682407.1
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    5. NM_001364583.2NP_001351512.1  peptidyl-glycine alpha-amidating monooxygenase isoform h precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS93754.1
      UniProtKB/TrEMBL
      A0A804HI59, A0A8C8KD64
      Related
      ENSP00000306100.8, ENST00000304400.12
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    6. NM_001364584.2NP_001351513.1  peptidyl-glycine alpha-amidating monooxygenase isoform i precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    7. NM_001364585.2NP_001351514.1  peptidyl-glycine alpha-amidating monooxygenase isoform j precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    8. NM_001364586.2NP_001351515.1  peptidyl-glycine alpha-amidating monooxygenase isoform k precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS93755.1
      UniProtKB/TrEMBL
      A0A804HI59, A0A804HIQ0
      Related
      ENSP00000507172.1, ENST00000682972.1
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    9. NM_001364587.2NP_001351516.1  peptidyl-glycine alpha-amidating monooxygenase isoform l precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    10. NM_001364588.2NP_001351517.1  peptidyl-glycine alpha-amidating monooxygenase isoform m precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    11. NM_001364589.2NP_001351518.1  peptidyl-glycine alpha-amidating monooxygenase isoform n precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    12. NM_001364590.2NP_001351519.1  peptidyl-glycine alpha-amidating monooxygenase isoform o

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS93757.1
      UniProtKB/TrEMBL
      A0A804HI59, A0A804HKM7
      Related
      ENSP00000507990.1, ENST00000682882.1
      Conserved Domains (3) summary
      cd14958
      Location:424731
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:392
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:120266
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    13. NM_001364591.2NP_001351520.1  peptidyl-glycine alpha-amidating monooxygenase isoform p precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:411718
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    14. NM_001364592.2NP_001351521.1  peptidyl-glycine alpha-amidating monooxygenase isoform q precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:411718
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    15. NM_001364593.2NP_001351522.1  peptidyl-glycine alpha-amidating monooxygenase isoform r precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    16. NM_001364594.2NP_001351523.1  peptidyl-glycine alpha-amidating monooxygenase isoform s precursor

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC010250, AC113373
      Consensus CDS
      CCDS93756.1
      UniProtKB/TrEMBL
      A0A804HI59, A0A804HKV8
      Related
      ENSP00000508091.1, ENST00000510208.2
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    17. NM_138766.2NP_620121.1  peptidyl-glycine alpha-amidating monooxygenase isoform b precursor

      See identical proteins and their annotated locations for NP_620121.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as PAM-15) lacks an alternate in-frame exon in the 3' coding region compared to variant 5. The encoded isoform (b) is shorter than isoform e. This isoform (b) may undergo proteolytic processing similar to isoform e.
      Source sequence(s)
      AC010250, BI966687, DA240822, S75038
      Consensus CDS
      CCDS4092.1
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    18. NM_138821.2NP_620176.1  peptidyl-glycine alpha-amidating monooxygenase isoform c precursor

      See identical proteins and their annotated locations for NP_620176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 5. The encoded isoform (c) is shorter than isoform e. This isoform (c) may undergo proteolytic processing similar to isoform e.
      Source sequence(s)
      AC010250, BI966687, BT007419, DA240822
      Consensus CDS
      CCDS4093.1
      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    19. NM_138822.2NP_620177.1  peptidyl-glycine alpha-amidating monooxygenase isoform d precursor

      See identical proteins and their annotated locations for NP_620177.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region compared to variant 5. The encoded isoform (d) is shorter than isoform e. This isoform (d) may undergo proteolytic processing similar to isoform e.
      Source sequence(s)
      AC010250, AF010472, BI966687, DA240822
      Consensus CDS
      CCDS4094.1
      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000282992.3, ENST00000346918.7
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RNA

    1. NR_033440.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon in the 5' region and uses two alternate splice sites in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC010250, AC113373, AK296521, BI966687, DA240822
    2. NR_157231.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC008501, AC008779, AC113373

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      102754783..103031105
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024446066.2XP_024301834.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. XM_024446069.2XP_024301837.1  peptidyl-glycine alpha-amidating monooxygenase isoform X6

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    3. XM_017009495.3XP_016864984.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    4. XM_017009496.3XP_016864985.1  peptidyl-glycine alpha-amidating monooxygenase isoform X3

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    5. XM_047417241.1XP_047273197.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

      UniProtKB/TrEMBL
      A0A804HI59
    6. XM_017009502.3XP_016864991.1  peptidyl-glycine alpha-amidating monooxygenase isoform X10

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    7. XM_024446072.2XP_024301840.1  peptidyl-glycine alpha-amidating monooxygenase isoform X11

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    8. XM_024446075.2XP_024301843.1  peptidyl-glycine alpha-amidating monooxygenase isoform X14

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    9. XM_017009511.3XP_016865000.1  peptidyl-glycine alpha-amidating monooxygenase isoform X21

      Conserved Domains (3) summary
      cd14958
      Location:518795
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    10. XM_024446080.2XP_024301848.1  peptidyl-glycine alpha-amidating monooxygenase isoform X22

      Conserved Domains (3) summary
      cd14958
      Location:518795
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    11. XM_024446081.2XP_024301849.1  peptidyl-glycine alpha-amidating monooxygenase isoform X26

      Conserved Domains (3) summary
      cd14958
      Location:518795
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    12. XM_024446070.2XP_024301838.1  peptidyl-glycine alpha-amidating monooxygenase isoform X8

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    13. XM_047417242.1XP_047273198.1  peptidyl-glycine alpha-amidating monooxygenase isoform X9

      UniProtKB/TrEMBL
      A0A804HI59
    14. XM_024446074.2XP_024301842.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000403461.2, ENST00000455264.7
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    15. XM_024446076.2XP_024301844.1  peptidyl-glycine alpha-amidating monooxygenase isoform X15

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    16. XM_047417249.1XP_047273205.1  peptidyl-glycine alpha-amidating monooxygenase isoform X24

    17. XM_047417250.1XP_047273206.1  peptidyl-glycine alpha-amidating monooxygenase isoform X25

    18. XM_047417251.1XP_047273207.1  peptidyl-glycine alpha-amidating monooxygenase isoform X27

    19. XM_024446078.2XP_024301846.1  peptidyl-glycine alpha-amidating monooxygenase isoform X17

      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000314638.3, ENST00000348126.7
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    20. XM_047417245.1XP_047273201.1  peptidyl-glycine alpha-amidating monooxygenase isoform X18

      UniProtKB/TrEMBL
      A0A804HI59
    21. XM_024446084.2XP_024301852.1  peptidyl-glycine alpha-amidating monooxygenase isoform X29

      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    22. XM_047417254.1XP_047273210.1  peptidyl-glycine alpha-amidating monooxygenase isoform X32

    23. XM_047417255.1XP_047273211.1  peptidyl-glycine alpha-amidating monooxygenase isoform X33

    24. XM_047417256.1XP_047273212.1  peptidyl-glycine alpha-amidating monooxygenase isoform X34

    25. XM_047417246.1XP_047273202.1  peptidyl-glycine alpha-amidating monooxygenase isoform X19

    26. XM_047417247.1XP_047273203.1  peptidyl-glycine alpha-amidating monooxygenase isoform X20

    27. XM_047417253.1XP_047273209.1  peptidyl-glycine alpha-amidating monooxygenase isoform X31

    28. XM_011543419.4XP_011541721.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      See identical proteins and their annotated locations for XP_011541721.1

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:518825
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    29. XM_017009497.3XP_016864986.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    30. XM_047417240.1XP_047273196.1  peptidyl-glycine alpha-amidating monooxygenase isoform X5

      UniProtKB/Swiss-Prot
      A6NMR0, A8K293, O43211, O95080, P19021, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0
      UniProtKB/TrEMBL
      A0A804HI59
    31. XM_047417243.1XP_047273199.1  peptidyl-glycine alpha-amidating monooxygenase isoform X12

      UniProtKB/TrEMBL
      A0A804HI59
    32. XM_017009505.3XP_016864994.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:500807
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    33. XM_017009507.3XP_016864996.1  peptidyl-glycine alpha-amidating monooxygenase isoform X16

      UniProtKB/TrEMBL
      A0A804HI59, A0A804HIQ0
      Conserved Domains (3) summary
      cd14958
      Location:393700
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:59168
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:196342
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    34. XM_047417244.1XP_047273200.1  peptidyl-glycine alpha-amidating monooxygenase isoform X17

      UniProtKB/TrEMBL
      A0A804HI59
    35. XM_024446085.2XP_024301853.1  peptidyl-glycine alpha-amidating monooxygenase isoform X30

      UniProtKB/TrEMBL
      A0A804HI59
      Conserved Domains (3) summary
      cd14958
      Location:442749
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:392
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:120266
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    36. XM_047417248.1XP_047273204.1  peptidyl-glycine alpha-amidating monooxygenase isoform X23

      UniProtKB/TrEMBL
      A0A804HI59
      Related
      ENSP00000369125.3, ENST00000379799.7
    37. XM_047417252.1XP_047273208.1  peptidyl-glycine alpha-amidating monooxygenase isoform X28

      UniProtKB/TrEMBL
      A0A804HI59

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      103262795..103539139
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352668.1XP_054208643.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A804HI59
    2. XM_054352674.1XP_054208649.1  peptidyl-glycine alpha-amidating monooxygenase isoform X6

      UniProtKB/TrEMBL
      A0A804HI59
    3. XM_054352670.1XP_054208645.1  peptidyl-glycine alpha-amidating monooxygenase isoform X2

      UniProtKB/TrEMBL
      A0A804HI59
    4. XM_054352671.1XP_054208646.1  peptidyl-glycine alpha-amidating monooxygenase isoform X3

      UniProtKB/TrEMBL
      A0A804HI59
    5. XM_054352675.1XP_054208650.1  peptidyl-glycine alpha-amidating monooxygenase isoform X7

      UniProtKB/TrEMBL
      A0A804HI59
    6. XM_054352678.1XP_054208653.1  peptidyl-glycine alpha-amidating monooxygenase isoform X10

      UniProtKB/TrEMBL
      A0A804HI59
    7. XM_054352679.1XP_054208654.1  peptidyl-glycine alpha-amidating monooxygenase isoform X11

      UniProtKB/TrEMBL
      A0A804HI59
    8. XM_054352683.1XP_054208658.1  peptidyl-glycine alpha-amidating monooxygenase isoform X14

      UniProtKB/TrEMBL
      A0A804HI59
    9. XM_054352691.1XP_054208666.1  peptidyl-glycine alpha-amidating monooxygenase isoform X21

    10. XM_054352692.1XP_054208667.1  peptidyl-glycine alpha-amidating monooxygenase isoform X22

    11. XM_054352696.1XP_054208671.1  peptidyl-glycine alpha-amidating monooxygenase isoform X26

    12. XM_054352676.1XP_054208651.1  peptidyl-glycine alpha-amidating monooxygenase isoform X8

      UniProtKB/TrEMBL
      A0A804HI59
    13. XM_054352677.1XP_054208652.1  peptidyl-glycine alpha-amidating monooxygenase isoform X9

      UniProtKB/TrEMBL
      A0A804HI59
    14. XM_054352681.1XP_054208656.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A804HI59
    15. XM_054352684.1XP_054208659.1  peptidyl-glycine alpha-amidating monooxygenase isoform X15

      UniProtKB/TrEMBL
      A0A804HI59
    16. XM_054352694.1XP_054208669.1  peptidyl-glycine alpha-amidating monooxygenase isoform X24

    17. XM_054352695.1XP_054208670.1  peptidyl-glycine alpha-amidating monooxygenase isoform X25

    18. XM_054352697.1XP_054208672.1  peptidyl-glycine alpha-amidating monooxygenase isoform X27

    19. XM_054352686.1XP_054208661.1  peptidyl-glycine alpha-amidating monooxygenase isoform X17

      UniProtKB/TrEMBL
      A0A804HI59
    20. XM_054352688.1XP_054208663.1  peptidyl-glycine alpha-amidating monooxygenase isoform X18

      UniProtKB/TrEMBL
      A0A804HI59
    21. XM_054352699.1XP_054208674.1  peptidyl-glycine alpha-amidating monooxygenase isoform X29

    22. XM_054352702.1XP_054208677.1  peptidyl-glycine alpha-amidating monooxygenase isoform X32

    23. XM_054352703.1XP_054208678.1  peptidyl-glycine alpha-amidating monooxygenase isoform X33

    24. XM_054352704.1XP_054208679.1  peptidyl-glycine alpha-amidating monooxygenase isoform X34

    25. XM_054352689.1XP_054208664.1  peptidyl-glycine alpha-amidating monooxygenase isoform X19

    26. XM_054352690.1XP_054208665.1  peptidyl-glycine alpha-amidating monooxygenase isoform X20

    27. XM_054352701.1XP_054208676.1  peptidyl-glycine alpha-amidating monooxygenase isoform X31

    28. XM_054352669.1XP_054208644.1  peptidyl-glycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A804HI59
    29. XM_054352672.1XP_054208647.1  peptidyl-glycine alpha-amidating monooxygenase isoform X4

      UniProtKB/TrEMBL
      A0A804HI59
    30. XM_054352673.1XP_054208648.1  peptidyl-glycine alpha-amidating monooxygenase isoform X5

      UniProtKB/Swiss-Prot
      A6NMR0, A8K293, O43211, O95080, P19021, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0
      UniProtKB/TrEMBL
      A0A804HI59
    31. XM_054352680.1XP_054208655.1  peptidyl-glycine alpha-amidating monooxygenase isoform X12

      UniProtKB/TrEMBL
      A0A804HI59
    32. XM_054352682.1XP_054208657.1  peptidyl-glycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A804HI59
    33. XM_054352685.1XP_054208660.1  peptidyl-glycine alpha-amidating monooxygenase isoform X16

      UniProtKB/TrEMBL
      A0A804HI59, A0A804HIQ0
    34. XM_054352687.1XP_054208662.1  peptidyl-glycine alpha-amidating monooxygenase isoform X17

      UniProtKB/TrEMBL
      A0A804HI59
    35. XM_054352700.1XP_054208675.1  peptidyl-glycine alpha-amidating monooxygenase isoform X30

      UniProtKB/TrEMBL
      A0A804HI59
    36. XM_054352693.1XP_054208668.1  peptidyl-glycine alpha-amidating monooxygenase isoform X23

      UniProtKB/TrEMBL
      A0A804HI59
    37. XM_054352698.1XP_054208673.1  peptidyl-glycine alpha-amidating monooxygenase isoform X28

      UniProtKB/TrEMBL
      A0A804HI59