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    PDGFA platelet derived growth factor subunit A [ Homo sapiens (human) ]

    Gene ID: 5154, updated on 9-Dec-2024

    Summary

    Official Symbol
    PDGFAprovided by HGNC
    Official Full Name
    platelet derived growth factor subunit Aprovided by HGNC
    Primary source
    HGNC:HGNC:8799
    See related
    Ensembl:ENSG00000197461 MIM:173430; AllianceGenome:HGNC:8799
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDGF1; PDGF-A
    Summary
    This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
    Expression
    Ubiquitous expression in lung (RPKM 8.8), placenta (RPKM 8.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PDGFA in Genome Data Viewer
    Location:
    7p22.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (497258..520700, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (598210..621677, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (536895..560337, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116435278 Neighboring gene uncharacterized LOC112267991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:473022-473858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:473859-474694 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:475441-476640 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:485302-485962 Neighboring gene uncharacterized LOC124901566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:499317-500044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:500045-500772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:510601-511557 Neighboring gene Sharpr-MPRA regulatory region 3057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:515046-515940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:519557-520077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:530277-531056 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:531057-531836 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:535084-536005 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:536006-536926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:543335-544112 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:549933-550440 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:550441-550948 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:551965-552472 Neighboring gene Sharpr-MPRA regulatory region 8552 Neighboring gene NANOG hESC enhancer GRCh37_chr7:555259-555760 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:556430-557352 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:558275-559196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17808 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17809 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:561041-561962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17812 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:570324-570520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:572659-573216 Neighboring gene PDGFA divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:578299-579242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:579243-580184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:592082-592582 Neighboring gene PRKAR1B antisense RNA 2 Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:611753-612521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:612522-613291 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:630646-630792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17813 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25471 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:643285-643970 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25473 Neighboring gene PRKAR1B antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates members of the PDGF/VEGF growth factor family (PDGFA, VEGFA,VEGFB, VEGFC) in mammary epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables collagen binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables growth factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables platelet-derived growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables platelet-derived growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables platelet-derived growth factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables platelet-derived growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in animal organ morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell activation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell projection assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in digestive tract development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic lung development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hair follicle development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lung alveolus development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of platelet activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in platelet-derived growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of ERK1 and ERK2 cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fibroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of mesenchymal cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of DNA biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in regulation of glomerular mesangial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of smooth muscle cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to wounding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in skin development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in wound healing TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microvillus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
     
    part_of platelet-derived growth factor complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    platelet-derived growth factor subunit A
    Names
    PDGF A-chain
    PDGF subunit A
    platelet-derived growth factor A-chain
    platelet-derived growth factor alpha chain
    platelet-derived growth factor alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029727.1 RefSeqGene

      Range
      4999..27587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001395363.1NP_001382292.1  platelet-derived growth factor subunit A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC147651
      Conserved Domains (2) summary
      smart00141
      Location:139226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:96140
      PDGF_N; Platelet-derived growth factor, N terminal region
    2. NM_001395364.1NP_001382293.1  platelet-derived growth factor subunit A isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC147651
      UniProtKB/TrEMBL
      H7BYW6
      Conserved Domains (1) summary
      smart00141
      Location:107194
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    3. NM_001395365.1NP_001382294.1  platelet-derived growth factor subunit A isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC147651
      UniProtKB/TrEMBL
      H7BYW6
      Conserved Domains (1) summary
      smart00141
      Location:97184
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    4. NM_001395366.1NP_001382295.1  platelet-derived growth factor subunit A isoform 2 preproprotein

      Status: VALIDATED

      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS47524.1
      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
    5. NM_002607.6NP_002598.4  platelet-derived growth factor subunit A isoform 1 preproprotein

      See identical proteins and their annotated locations for NP_002598.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The protein contains a C-terminal basic motif encoded by exon 6, the exon missing in variant 2.
      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS34578.1
      UniProtKB/Swiss-Prot
      B5BU73, P04085
      UniProtKB/TrEMBL
      A8K852
      Related
      ENSP00000346508.5, ENST00000354513.9
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region
    6. NM_033023.5NP_148983.1  platelet-derived growth factor subunit A isoform 2 preproprotein

      See identical proteins and their annotated locations for NP_148983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks exon 6, compared to variant 1, and encodes the shorter isoform (2).
      Source sequence(s)
      AC147651
      Consensus CDS
      CCDS47524.1
      UniProtKB/TrEMBL
      A8K852
      Related
      ENSP00000383889.3, ENST00000402802.8
      Conserved Domains (2) summary
      smart00141
      Location:94181
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2195
      PDGF_N; Platelet-derived growth factor, N terminal region

    RNA

    1. NR_172526.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147651
    2. NR_172527.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC147651

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      497258..520700 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420456.1XP_047276412.1  platelet-derived growth factor subunit A isoform X6

      UniProtKB/TrEMBL
      A8K852
    2. XM_047420455.1XP_047276411.1  platelet-derived growth factor subunit A isoform X4

    3. XM_011515415.2XP_011513717.1  platelet-derived growth factor subunit A isoform X1

      Conserved Domains (2) summary
      smart00141
      Location:139226
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:101140
      PDGF_N; Platelet-derived growth factor, N terminal region
    4. XM_011515418.2XP_011513720.1  platelet-derived growth factor subunit A isoform X3

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:132219
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:59133
      PDGF_N; Platelet-derived growth factor, N terminal region
    5. XM_011515416.2XP_011513718.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (1) summary
      smart00141
      Location:132219
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    6. XM_047420457.1XP_047276413.1  platelet-derived growth factor subunit A isoform X7

      UniProtKB/Swiss-Prot
      B5BU73, P04085
      UniProtKB/TrEMBL
      A8K852
    7. XM_017012289.2XP_016867778.1  platelet-derived growth factor subunit A isoform X5

      UniProtKB/TrEMBL
      A8K852
    8. XM_047420458.1XP_047276414.1  platelet-derived growth factor subunit A isoform X9

      UniProtKB/TrEMBL
      H7BYW6
    9. XM_011515419.4XP_011513721.1  platelet-derived growth factor subunit A isoform X8

      UniProtKB/TrEMBL
      A8K852
      Conserved Domains (2) summary
      smart00141
      Location:93180
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
      pfam04692
      Location:2194
      PDGF_N; Platelet-derived growth factor, N terminal region

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      598210..621677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358366.1XP_054214341.1  platelet-derived growth factor subunit A isoform X6

      UniProtKB/TrEMBL
      A8K852
    2. XM_054358364.1XP_054214339.1  platelet-derived growth factor subunit A isoform X4

    3. XM_054358361.1XP_054214336.1  platelet-derived growth factor subunit A isoform X1

    4. XM_054358363.1XP_054214338.1  platelet-derived growth factor subunit A isoform X3

      UniProtKB/TrEMBL
      A8K852
    5. XM_054358362.1XP_054214337.1  platelet-derived growth factor subunit A isoform X2

      UniProtKB/TrEMBL
      A8K852
    6. XM_054358367.1XP_054214342.1  platelet-derived growth factor subunit A isoform X7

      UniProtKB/Swiss-Prot
      B5BU73, P04085
      UniProtKB/TrEMBL
      A8K852
    7. XM_054358365.1XP_054214340.1  platelet-derived growth factor subunit A isoform X5

      UniProtKB/TrEMBL
      A8K852
    8. XM_054358369.1XP_054214344.1  platelet-derived growth factor subunit A isoform X9

      UniProtKB/TrEMBL
      H7BYW6
    9. XM_054358368.1XP_054214343.1  platelet-derived growth factor subunit A isoform X8

      UniProtKB/TrEMBL
      A8K852