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    FABP6 fatty acid binding protein 6 [ Homo sapiens (human) ]

    Gene ID: 2172, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FABP6provided by HGNC
    Official Full Name
    fatty acid binding protein 6provided by HGNC
    Primary source
    HGNC:HGNC:3561
    See related
    Ensembl:ENSG00000170231 MIM:600422; AllianceGenome:HGNC:3561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ILBP; I-15P; I-BAP; ILBP3; ILLBP; I-BABP; I-BALB
    Summary
    This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward small intestine (RPKM 820.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See FABP6 in Genome Data Viewer
    Location:
    5q33.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (160187381..160238722)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (160715939..160767284)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (159614388..159665729)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901124 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159455528-159455695 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159469604-159470298 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159470299-159470993 Neighboring gene tetratricopeptide repeat domain 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:159487609-159488120 Neighboring gene PWWP domain containing 2A Neighboring gene MPRA-validated peak5557 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:159507098-159508004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159508005-159508910 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:159513521-159513688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23555 Neighboring gene MPRA-validated peak5558 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16575 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159546009-159546508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16578 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23557 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159588248-159588903 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:159589561-159590215 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159591897-159592496 Neighboring gene Sharpr-MPRA regulatory region 721 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:159593698-159594298 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159602660-159603248 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16579 Neighboring gene MPRA-validated peak5559 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16580 Neighboring gene FABP6 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16581 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:159664401-159665356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23558 Neighboring gene uncharacterized LOC105377691 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene cyclin J like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma. Fang C, et al. Cancer Res, 2007 Oct 1. PMID 17909007
    2. Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein. Fujita M, et al. Eur J Biochem, 1995 Oct 15. PMID 7588781
    3. Cloning and chromosomal localization of the human ileal lipid-binding protein. Oelkers P, et al. Biochim Biophys Acta, 1995 Jul 13. PMID 7619861
    4. Immunohistochemical distribution of intestinal 15 kDa protein in human tissues. Watanabe K, et al. Arch Histol Cytol, 1995 Aug. PMID 8527237
    5. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. Kurz M, et al. Proteins, 2003 Feb 1. PMID 12486725

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway.
      Title: REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway.
    2. Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
      Title: Multiple Timescale Dynamic Analysis of Functionally-Impairing Mutations in Human Ileal Bile Acid-Binding Protein.
    3. Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
      Title: Fatty Acid Binding Protein 6 Inhibition Decreases Cell Cycle Progression, Migration and Autophagy in Bladder Cancers.
    4. Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
      Title: Inhibition of FABP6 Reduces Tumor Cell Invasion and Angiogenesis through the Decrease in MMP-2 and VEGF in Human Glioblastoma Cells.
    5. Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
      Title: Study of FABP's interactome and detecting new molecular targets in clear cell renal cell carcinoma.
    6. Functional suppression of FABP7 significantly inhibited SKRC10 clear cell renal cell carcinoma (ccRCC) cells growth and resulted in a significant reduction of the invasive potential but did not cause growth inhibition of SKRC7 cells. Functional suppression of FABP6 resulted in significant growth inhibition of SKRC7 cells. This is the first report about the complementary role of FABP6 for FABP7 in ccRCC.
      Title: Fatty acid binding protein 7 may be a marker and therapeutic targets in clear cell renal cell carcinoma.
    7. Experimental analysis showed the importance of LEF1, ETV4 and FABP6 as three co-regulated prognostic markers in patients with colorectal cancer metastasis.
      Title: An integrated study on TFs and miRNAs in colorectal cancer metastasis and evaluation of three co-regulated candidate genes as prognostic markers.
    8. Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR
      Title: Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.
    9. Analysis of slow and fast motions in I-BABP indicates largely different energy landscapes for the apo and holo states suggesting that optimization of binding interactions might be achieved by altering the dynamic behavior of specific protein segments.
      Title: Temperature dependence of backbone dynamics in human ileal bile acid-binding protein: implications for the mechanism of ligand binding.
    10. show, using electrospray ionization mass spectroscopy, that human ILBP binds bile acids with a 3:1 ratio, even at low protein and ligand concentrations
      Title: Cooperativity and site selectivity in the ileal lipid binding protein.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gastrotropin
    Names
    GT
    fatty acid binding protein 6, ileal
    ileal bile acid binding protein
    ileal lipid-binding protein
    illeal lipid-binding protein
    intestinal 15 kDa protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029500.1 RefSeqGene

      Range
      47140..56350
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001040442.1 → NP_001035532.1  gastrotropin isoform 1

      See identical proteins and their annotated locations for NP_001035532.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AI208231, BC022489, X90908
      Consensus CDS
      CCDS43393.1
      UniProtKB/Swiss-Prot
      P51161
      Conserved Domains (1) summary
      pfam14651
      Location:52 → 177
      Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

    2. NM_001130958.2 → NP_001124430.1  gastrotropin isoform 1

      See identical proteins and their annotated locations for NP_001124430.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an additional 5' exon, as compared to variant 1. Both variants 1 and 3 encode the same isoform 1.
      Source sequence(s)
      DQ132786
      Consensus CDS
      CCDS43393.1
      UniProtKB/Swiss-Prot
      P51161
      Related
      ENSP00000377549.4, ENST00000393980.8
      Conserved Domains (1) summary
      pfam14651
      Location:52 → 177
      Lipocalin_7; Lipocalin / cytosolic fatty-acid binding protein family

    3. NM_001445.3 → NP_001436.1  gastrotropin isoform 2

      See identical proteins and their annotated locations for NP_001436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two 5' exons and has an alternate 5' sequence, and the translation initiation starts from a downstream AUG codon, as compared to variant 1. The encoded protein (isoform 2) is dominant and shorter at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      X90908
      Consensus CDS
      CCDS4349.1
      UniProtKB/Swiss-Prot
      P51161, Q07DR7, Q8TBI3, Q9UGI7
      Related
      ENSP00000385433.4, ENST00000402432.4
      Conserved Domains (1) summary
      cl21528
      Location:1 → 128
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      160187381..160238722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      160715939..160767284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P51161.2 GenPept UniProtKB/Swiss-Prot:P51161

    Gene LinkOut

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