MYO1G myosin IG [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYO1Gprovided by HGNC
Official Full Name: myosin IGprovided by HGNC
Primary source: HGNC:HGNC:13880
See related: Ensembl:ENSG00000136286 MIM:600642; AllianceGenome:HGNC:13880
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HA2; MHAG; HLA-HA2
Summary: MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]
Expression: Biased expression in bone marrow (RPKM 19.0), spleen (RPKM 14.5) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7p13

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (44962662..44979015, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (45123008..45139360, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (45002261..45018614, complement)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in Lung Cancer.
Title: Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in Lung Cancer.
Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies.
Title: Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies.
Maternal-smoking sensitive CpG sites in newborns were significantly associated with rs61087368 SNP located proximal to MYO1G.
Title: Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
the information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population
Title: Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation.
gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia
Title: Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs.
Observational study of gene-disease association. (HuGE Navigator)
Title: Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation.
Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain
Title: Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH).

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of myosin IG (MYO1G) expression by HIV-1 Vpr in Vpr transduced macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-3,4-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol-4,5-bisphosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Fc-gamma receptor signaling pathway involved in phagocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell meandering migration	IEA Inferred from Electronic Annotation more info
involved_in T cell mediated immunity	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell gliding	IEA Inferred from Electronic Annotation more info
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of localization in cell	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in leading edge membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in phagocytic cup	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: unconventional myosin-Ig

Names: minor histocompatibility antigen HA-2; myosin-Ig

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033054.3 → NP_149043.2 unconventional myosin-Ig

See identical proteins and their annotated locations for NP_149043.2

Status: VALIDATED

Source sequence(s)

AA651942, AC004847, BC117241

Consensus CDS

CCDS34629.1

UniProtKB/Swiss-Prot

B0I1T2, Q8TEI9, Q8TES2, Q96BE2, Q96RI5, Q96RI6

UniProtKB/TrEMBL

A0A3B3IU30

Related

ENSP00000258787.7, ENST00000258787.12

Conserved Domains (3) summary

smart00242
Location:4 → 706

MYSc; Myosin. Large ATPases

cd01378
Location:23 → 694

MYSc_Myo1; class I myosin, motor domain

pfam06017
Location:815 → 980

Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding