F11R F11 receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: F11Rprovided by HGNC
Official Full Name: F11 receptorprovided by HGNC
Primary source: HGNC:HGNC:14685
See related: Ensembl:ENSG00000158769 MIM:605721; AllianceGenome:HGNC:14685
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
Summary: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1q23.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (160995211..161021152, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (160132277..160158230, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (160965001..160990942, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
Title: JAM-A Overexpression in Human Umbilical Cord-Derived Mesenchymal Stem Cells Accelerated the Angiogenesis of Diabetic Wound By Enhancing Both Paracrine Function and Survival of Mesenchymal Stem Cells.
A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
Title: A Transcriptional Link between HER2, JAM-A and FOXA1 in Breast Cancer.
MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
Title: MIR21-induced loss of junctional adhesion molecule A promotes activation of oncogenic pathways, progression and metastasis in colorectal cancer.
Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
Title: Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation.
LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
Title: LncRNA TP73-AS1 regulates miR-495 expression to promote migration and invasion of nasopharyngeal carcinoma cells through junctional adhesion molecule A.
Association of F11R polymorphisms and gene expression with primary Sjogren's syndrome patients.
Title: Association of F11R polymorphisms and gene expression with primary Sjögren's syndrome patients.
Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
Title: Helicobacter pylori PqqE is a new virulence factor that cleaves junctional adhesion molecule A and disrupts gastric epithelial integrity.
Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
Title: Anti-CD321 antibody immunotherapy protects liver against ischemia and reperfusion-induced injury.
Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
Title: Low junctional adhesion molecule-A expression is associated with an epithelial to mesenchymal transition and poorer outcomes in high-grade serous carcinoma of uterine adnexa.
Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.
Title: Aberrant expression of junctional adhesion molecule-A contributes to the malignancy of cervical adenocarcinoma by interaction with poliovirus receptor/CD155.

Submit: New GeneRIF Correction See all GeneRIFs (102)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of F11R	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC)	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10S275 (e-PCR)
- UniSTS:147992

G59842 (e-PCR)
- UniSTS:136991

D8S2279 (e-PCR)
- UniSTS:473907

D1S3328 (e-PCR)
- UniSTS:37753

RH36905 (e-PCR)
- UniSTS:87932

D11S3114 (e-PCR)
- UniSTS:152207

D1S3269 (e-PCR)
- UniSTS:29615

SGC34299 (e-PCR)
- UniSTS:48830

F11R_1772 (e-PCR)
- UniSTS:277219

A006O06 (e-PCR)
- UniSTS:5368

RH18213 (e-PCR)
- UniSTS:71417

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables virus receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actomyosin structure organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to mechanical stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of endothelial intestinal barrier	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of endothelial intestinal barrier	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of endothelial intestinal barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in intestinal absorption	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of blood-brain barrier	NAS Non-traceable Author Statement more info	PubMed
involved_in memory T cell extravasation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rho protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet aggregation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to bicellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of membrane permeability	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	TAS Traceable Author Statement more info
located_in cell-cell junction	TAS Traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in tight junction	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: junctional adhesion molecule A

Names: junctional adhesion molecule 1; platelet F11 receptor; platelet adhesion molecule 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001348091.2 → NP_001335020.1 junctional adhesion molecule A isoform 6 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK304412, AL591806

Consensus CDS

CCDS86026.1

UniProtKB/TrEMBL

Q9Y5B2

Related

ENSP00000440812.1, ENST00000537746.1

Conserved Domains (1) summary

pfam13927
Location:78 → 167

Ig_3; Immunoglobulin domain
NM_001382727.1 → NP_001369656.1 junctional adhesion molecule A isoform 7 precursor

Status: REVIEWED

Source sequence(s)

AL591806

UniProtKB/TrEMBL

B7Z5W1, E7EPV8

Conserved Domains (2) summary

cd20946
Location:30 → 129

IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains

cd20950
Location:135 → 231

IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
NM_001382730.1 → NP_001369659.1 junctional adhesion molecule A isoform 8 precursor

Status: REVIEWED

Source sequence(s)

AL591806

UniProtKB/TrEMBL

Q9Y5B2

Conserved Domains (2) summary

cd20946
Location:30 → 129

IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains

cd20950
Location:135 → 231

IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
NM_001382733.1 → NP_001369662.1 junctional adhesion molecule A isoform 9 precursor

Status: REVIEWED

Source sequence(s)

AL591806

UniProtKB/TrEMBL

Q9Y5B2

Conserved Domains (2) summary

cd20946
Location:30 → 129

IgV_1_JAM1-like; First Ig-like domain of Junctional adhesion molecule-1 (JAM1)and similar domains; a member of the V-set of IgSF domains

cd20950
Location:135 → 231

IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains
NM_001382734.1 → NP_001369663.1 junctional adhesion molecule A isoform 10 precursor

Status: REVIEWED

Source sequence(s)

AL591806

UniProtKB/TrEMBL

Q9Y5B2

Conserved Domains (3) summary

cd00096
Location:22 → 30

Ig; Ig strand B [structural motif]

cd20950
Location:112 → 208

IgI_2_JAM1; Second Ig-like domain of Junctional adhesion molecule-1 (JAM1); a member of the I-set of IgSF domains

cl11960
Location:22 → 106

Ig; Immunoglobulin domain
NM_016946.6 → NP_058642.1 junctional adhesion molecule A isoform 1 precursor

See identical proteins and their annotated locations for NP_058642.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AF172398, AL591806, DA907460

Consensus CDS

CCDS1213.1

UniProtKB/Swiss-Prot

B7Z941, Q9Y624

UniProtKB/TrEMBL

Q6FIB4, Q9Y5B2

Related

ENSP00000357005.5, ENST00000368026.11

Conserved Domains (2) summary

smart00410
Location:36 → 125

IG_like; Immunoglobulin like

pfam13927
Location:135 → 216

Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

160995211..161021152 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

160132277..160158230 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_144501.1: Suppressed sequence

Description

NM_144501.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_144502.1: Suppressed sequence

Description

NM_144502.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
NM_144503.1: Suppressed sequence

Description

NM_144503.1: This RefSeq was permanently suppressed because it is now thought that it represents a rare read-through transcript.
NM_144504.1: Suppressed sequence

Description

NM_144504.1: This RefSeq was removed because currently there is insufficient support for the transcript.