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    TAS1R2 taste 1 receptor member 2 [ Homo sapiens (human) ]

    Gene ID: 80834, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAS1R2provided by HGNC
    Official Full Name
    taste 1 receptor member 2provided by HGNC
    Primary source
    HGNC:HGNC:14905
    See related
    Ensembl:ENSG00000179002 MIM:606226; AllianceGenome:HGNC:14905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TR2; T1R2; GPR71
    Summary
    Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See TAS1R2 in Genome Data Viewer
    Location:
    1p36.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (18839599..18859660, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (18659394..18679451, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19166093..19186154, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18877005-18877829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18879379-18879880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18879881-18880380 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18883865-18884372 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18884373-18884880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18898371-18898870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18901646-18902224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18902225-18902802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18925717-18926246 Neighboring gene PAX7 promoter region Neighboring gene PAX7 intron homotypic clusters of transcription factor binding sites enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18962444-18963061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18963062-18963678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18963679-18964296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18967445-18967966 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18976025-18976654 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:18978097-18978886 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:18979869-18980025 Neighboring gene Sharpr-MPRA regulatory region 1855 Neighboring gene paired box 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19018361-19018860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19064331-19064838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19064839-19065345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19066201-19066702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19119189-19119690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19119691-19120190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19144000-19144500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19146197-19146706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19146707-19147216 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19147395-19147573 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19176158-19176291 Neighboring gene Sharpr-MPRA regulatory region 7483 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19210623-19210854 Neighboring gene aldehyde dehydrogenase 4 family member A1 Neighboring gene microRNA 4695 Neighboring gene microRNA 1290

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns. Hoti Q, et al. Mol Biol Rep, 2023 Nov. PMID 37817023
    2. Variation in the TAS1R2 Gene, Sweet Taste Perception and Intake of Sugars. Dias AG, et al. J Nutrigenet Nutrigenomics, 2015. PMID 26279452
    3. Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico. Ramos-Lopez O, et al. Nutrients, 2016 Feb 19. PMID 26907331, Free PMC Article
    4. Temperature-dependent conformational change affecting Tyr11 and sweetness loops of brazzein. Cornilescu CC, et al. Proteins, 2013 Jun. PMID 23349025, Free PMC Article
    5. Structure-based screening for discovery of sweet compounds. Ben Shoshan-Galeczki Y, et al. Food Chem, 2020 Jun 15. PMID 32018080

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.
      Title: Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries.
    2. Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
      Title: Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
    3. The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
      Title: The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
    4. Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
      Title: Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
    5. Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
      Title: Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
    6. The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
      Title: The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
    7. Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
      Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
    8. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
      Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    9. Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
      Title: Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
    10. Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
      Title: Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
    Submit: New GeneRIF Correction See all GeneRIFs (36)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sweet taste receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to sweet taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to taste receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables taste receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sweet taste IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sweet taste IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of sweet taste receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sweet taste receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    taste receptor type 1 member 2
    Names
    G-protein coupled receptor 71
    sweet taste receptor T1R2
    taste receptor, type 1, member 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152232.6 → NP_689418.2  taste receptor type 1 member 2 precursor

      See identical proteins and their annotated locations for NP_689418.2

      Status: VALIDATED

      Source sequence(s)
      AL831755, BX537160
      Consensus CDS
      CCDS187.1
      UniProtKB/Swiss-Prot
      Q5TZ19, Q8TE23
      Related
      ENSP00000364520.3, ENST00000375371.4
      Conserved Domains (4) summary
      cd06363
      Location:27 → 484
      PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
      pfam00003
      Location:577 → 814
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:70 → 454
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:493 → 543
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      18839599..18859660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      18659394..18679451 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TE23.2 GenPept UniProtKB/Swiss-Prot:Q8TE23

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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