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    MIOX myo-inositol oxygenase [ Homo sapiens (human) ]

    Gene ID: 55586, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIOXprovided by HGNC
    Official Full Name
    myo-inositol oxygenaseprovided by HGNC
    Primary source
    HGNC:HGNC:14522
    See related
    Ensembl:ENSG00000100253 MIM:606774; AllianceGenome:HGNC:14522
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALDRL6
    Summary
    Enables ferric iron binding activity and inositol oxygenase activity. Involved in inositol catabolic process. Predicted to be located in cytoplasm and inclusion body. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward kidney (RPKM 162.3) See more
    Orthologs
    mouse all
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    Genomic context

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    See MIOX in Genome Data Viewer
    Location:
    22q13.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50486859..50490648)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50996041..50999830)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50925288..50929077)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene adrenomedullin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13983 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50955745-50956678 Neighboring gene lipase maturation factor 2 Neighboring gene non-SMC condensin II complex subunit H2 Neighboring gene synthesis of cytochrome C oxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus. Yang B, et al. J Diabetes Complications, 2010 Nov-Dec. PMID 19896870
    2. myo-inositol oxygenase from rat kidneys. Substrate-dependent oligomerization. Koller F, et al. Eur J Biochem, 1990 Oct 24. PMID 2226462
    3. The inositol phospholipids: a stereochemical view of biological activity. Parthasarathy R, et al. Biochem J, 1986 Apr 15. PMID 3017301, Free PMC Article
    4. Up-regulation of human myo-inositol oxygenase by hyperosmotic stress in renal proximal tubular epithelial cells. Prabhu KS, et al. J Biol Chem, 2005 May 20. PMID 15778219
    5. MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Meng L, et al. Redox Biol, 2023 Dec. PMID 37977044, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
      Title: MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma.
    2. Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
      Title: Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome.
    3. Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
      Title: Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA.
    4. Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
      Title: Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes.
    5. MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury.
      Title: Myo-inositol oxygenase accentuates renal tubular injury initiated by endoplasmic reticulum stress.
    6. increased MIOX expression in the kidney contributes to tubular damage in DN (Diabetic Nephropathy). The concentration of MIOX in the serum and urine may serve as a new biomarker for the early diagnosis of DN.
      Title: The Kidney Specific Protein myo-Inositol Oxygenase, a Potential Biomarker for Diabetic Nephropathy.
    7. Our results suggest that serum MIOX levels do not change in polycystic ovary syndrome. It was, therefore, concluded that myoinositol deficiency observed in PCOS was not related to the level of MIOX enzyme which cleaves myoinositol.
      Title: Does myo-inositol oxygenase, the only enzyme to catalyze myo-inositol in vivo, play a role in the etiology of polycystic ovarian syndrome?
    8. these findings highlight the epigenetic regulation of MIOX in the pathogenesis of diabetic tubulopathy.
      Title: High Glucose-Induced Hypomethylation Promotes Binding of Sp-1 to Myo-Inositol Oxygenase: Implication in the Pathobiology of Diabetic Tubulopathy.
    9. Data suggest that MIOX expression/activity is up-regulated in kidneys tubules during oxidative stress (as in obesity and diabetic nephropathy); up-regulation of MIOX activity is related to phosphorylation of serine/threonine residues.
      Title: Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids: IMPLICATIONS IN RENAL TUBULAR INJURY INDUCED IN OBESITY AND DIABETES.
    10. results demonstrated that the polymorphism (rs761745) in the promoter region of myo-inositol oxygenase(MIOX) gene may be associated with the development of type 1 diabetes mellitus in our studied population
      Title: Polymorphisms of myo-inositol oxygenase gene are associated with Type 1 diabetes mellitus.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ferric iron binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol oxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inositol oxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inositol oxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in inositol catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in inclusion body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inositol oxygenase
    Names
    MI oxygenase
    aldehyde reductase (aldose reductase) like 6
    aldehyde reductase-like 6
    kidney-specific protein 32
    renal-specific oxidoreductase
    NP_060054.4
    XP_005261982.1
    XP_011529007.1
    XP_047297399.1
    XP_054181762.1
    XP_054181763.1
    XP_054181764.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017584.6 → NP_060054.4  inositol oxygenase

      See identical proteins and their annotated locations for NP_060054.4

      Status: VALIDATED

      Source sequence(s)
      AF197129, AL096767, BC012025, BC064395
      Consensus CDS
      CCDS14092.1
      UniProtKB/Swiss-Prot
      Q05DJ6, Q5S8C9, Q9BZZ1, Q9UGB7, Q9UHB8
      UniProtKB/TrEMBL
      A6PVH4
      Related
      ENSP00000216075.6, ENST00000216075.11
      Conserved Domains (1) summary
      pfam05153
      Location:37 → 285
      MIOX; Myo-inositol oxygenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      50486859..50490648
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047441443.1 → XP_047297399.1  inositol oxygenase isoform X3

      Related
      ENSP00000379082.3, ENST00000395733.7

    2. XM_011530705.3 → XP_011529007.1  inositol oxygenase isoform X2

      Conserved Domains (1) summary
      pfam05153
      Location:37 → 113
      MIOX; Myo-inositol oxygenase

    3. XM_005261925.5 → XP_005261982.1  inositol oxygenase isoform X1

      UniProtKB/TrEMBL
      A6PVH4
      Conserved Domains (1) summary
      pfam05153
      Location:1 → 239
      MIOX; Myo-inositol oxygenase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      50996041..50999830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325789.1 → XP_054181764.1  inositol oxygenase isoform X3

    2. XM_054325788.1 → XP_054181763.1  inositol oxygenase isoform X2

    3. XM_054325787.1 → XP_054181762.1  inositol oxygenase isoform X1

      UniProtKB/TrEMBL
      A6PVH4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UGB7.1 GenPept UniProtKB/Swiss-Prot:Q9UGB7

    Gene LinkOut

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