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    TAAR5 trace amine associated receptor 5 [ Homo sapiens (human) ]

    Gene ID: 9038, updated on 10-Dec-2024

    Summary

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    Official Symbol
    TAAR5provided by HGNC
    Official Full Name
    trace amine associated receptor 5provided by HGNC
    Primary source
    HGNC:HGNC:30236
    See related
    Ensembl:ENSG00000135569 MIM:607405; AllianceGenome:HGNC:30236
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PNR; taR-5
    Summary
    Enables trimethylamine receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and cognition. Is active in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    mouse all
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    Genomic context

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    See TAAR5 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132588592..132616747, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133783556..133811705, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132909731..132937886, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 7, pseudogene Neighboring gene trace amine associated receptor 6 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene Neighboring gene trace amine associated receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17552 Neighboring gene trace amine associated receptor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis. Vaganova AN, et al. Int J Mol Sci, 2021 Aug 16. PMID 34445502, Free PMC Article
    2. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming. Gisladottir RS, et al. Curr Biol, 2020 Dec 7. PMID 33035477
    3. Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5. Dinter J, et al. PLoS One, 2015. PMID 25706283, Free PMC Article
    4. Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain. Zeng Z, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464258
    5. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine. Wallrabenstein I, et al. PLoS One, 2013. PMID 23393561, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis.
      Title: Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis.
    2. Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming.
      Title: Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming.
    3. The murine and human TAAR5 (hTAAR5) display significant basal activity in the Gq/11 pathway.
      Title: Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5.
    4. Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
      Title: Human trace amine-associated receptor TAAR5 can be activated by trimethylamine.
    5. Previous studies reported TAAR expression in brain. This paper found TAAR expression only in olfactory epithelial cells and that each TAAR detects a unique set of amine ligands. TAARs seem to function as a family of chemosensory receptors for amines.
      Title: A second class of chemosensory receptors in the olfactory epithelium.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC138414, MGC138416

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trimethylamine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of smell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trace amine-associated receptor 5
    Names
    putative neurotransmitter receptor
    trace amine receptor 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001389527.1 → NP_001376456.1  trace amine-associated receptor 5

      Status: VALIDATED

      Source sequence(s)
      AL513524
      Consensus CDS
      CCDS5156.1
      UniProtKB/Swiss-Prot
      D8KZS1, O14804, Q2M1V1, Q4VBL1, Q5VUQ3, Q6NTA8
      Conserved Domains (1) summary
      cd15318
      Location:35 → 316
      7tmA_TAAR5; trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_003967.3 → NP_003958.2  trace amine-associated receptor 5

      See identical proteins and their annotated locations for NP_003958.2

      Status: VALIDATED

      Source sequence(s)
      AL513524
      Consensus CDS
      CCDS5156.1
      UniProtKB/Swiss-Prot
      D8KZS1, O14804, Q2M1V1, Q4VBL1, Q5VUQ3, Q6NTA8
      Related
      ENSP00000258034.2, ENST00000258034.4
      Conserved Domains (1) summary
      cd15318
      Location:35 → 316
      7tmA_TAAR5; trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132588592..132616747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133783556..133811705 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O14804.2 GenPept UniProtKB/Swiss-Prot:O14804

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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