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    GPRC5D G protein-coupled receptor class C group 5 member D [ Homo sapiens (human) ]

    Gene ID: 55507, updated on 10-Dec-2024

    Summary

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    Official Symbol
    GPRC5Dprovided by HGNC
    Official Full Name
    G protein-coupled receptor class C group 5 member Dprovided by HGNC
    Primary source
    HGNC:HGNC:13310
    See related
    Ensembl:ENSG00000111291 MIM:607437; AllianceGenome:HGNC:13310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See GPRC5D in Genome Data Viewer
    Location:
    12p13.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (12940575..12952170, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (12814207..12827419, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13093509..13105104, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902881 Neighboring gene RPL13AP20-GPRC5A intergenic CAGE-defined mid-level expression enhancer Neighboring gene G protein-coupled receptor class C group 5 member A Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13058787 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13059781 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13073965 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:13075202 Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene heme binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4269

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review. Rodriguez-Otero P, et al. Blood Cancer J, 2024 Feb 2. PMID 38307865, Free PMC Article
    2. Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells. Mi X, et al. N Engl J Med, 2023 Oct 12. PMID 37819961
    3. Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation. Derrien J, et al. Nat Cancer, 2023 Nov. PMID 37653140
    4. GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer. Mei J, et al. J Transl Med, 2023 Aug 13. PMID 37574551, Free PMC Article
    5. GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells. Cohen Y, et al. Hematology, 2013 Nov. PMID 23510526

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.
      Title: GPRC5D as a novel target for the treatment of multiple myeloma: a narrative review.
    2. Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.
      Title: Acquired resistance to a GPRC5D-directed T-cell engager in multiple myeloma is mediated by genetic or epigenetic target inactivation.
    3. Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.
      Title: Genetic Basis of Relapse after GPRC5D-Targeted CAR T Cells.
    4. GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.
      Title: GPRC5D as a promising therapeutic target in EGFR-wild and immuno-cold non-small cell lung cancer.
    5. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies.
      Title: GPRC5D is a promising marker for monitoring the tumor load and to target multiple myeloma cells.
    6. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.
      Title: Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma.
    7. Observational study of gene-disease association. (HuGE Navigator)
      Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC129713, MGC129714

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular exosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor family C group 5 member D
    Names
    orphan G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018654.2 → NP_061124.1  G-protein coupled receptor family C group 5 member D

      See identical proteins and their annotated locations for NP_061124.1

      Status: REVIEWED

      Source sequence(s)
      AC007688
      Consensus CDS
      CCDS8658.1
      UniProtKB/Swiss-Prot
      Q3KNV3, Q7Z5J9, Q8TDS6, Q9NZD1
      Related
      ENSP00000228887.1, ENST00000228887.6
      Conserved Domains (2) summary
      cd14964
      Location:22 → 46
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:21 → 267
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      12940575..12952170 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017019583.3 → XP_016875072.1  G-protein coupled receptor family C group 5 member D isoform X1

      UniProtKB/Swiss-Prot
      Q9NZD1
      Related
      ENSP00000379624.3, ENST00000396333.3
      Conserved Domains (1) summary
      pfam00003
      Location:75 → 264
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      12814207..12827419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372460.1 → XP_054228435.1  G-protein coupled receptor family C group 5 member D isoform X2

      UniProtKB/Swiss-Prot
      Q3KNV3, Q7Z5J9, Q8TDS6, Q9NZD1

    2. XM_054372461.1 → XP_054228436.1  G-protein coupled receptor family C group 5 member D isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NZD1.1 GenPept UniProtKB/Swiss-Prot:Q9NZD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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