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    POTEB POTE ankyrin domain family member B [ Homo sapiens (human) ]

    Gene ID: 100996331, updated on 3-Dec-2024

    Summary

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    Official Symbol
    POTEBprovided by HGNC
    Official Full Name
    POTE ankyrin domain family member Bprovided by HGNC
    Primary source
    HGNC:HGNC:33734
    See related
    Ensembl:ENSG00000233917 MIM:608912; AllianceGenome:HGNC:33734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    A26B1; POTE15; POTEB2; CT104.5; POTE-15
    Expression
    Restricted expression toward testis (RPKM 5.8) See more
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    Genomic context

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    See POTEB in Genome Data Viewer
    Location:
    15q11.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (21846329..21877735, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (22051853..22083259, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379207 Neighboring gene microRNA 3118-4 Neighboring gene RNA, U6 small nuclear 631, pseudogene Neighboring gene vomeronasal 1 receptor 62 pseudogene Neighboring gene vomeronasal 1 receptor 63 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Personalized copy number and segmental duplication maps using next-generation sequencing. Alkan C, et al. Nat Genet, 2009 Oct. PMID 19718026, Free PMC Article
    2. Five POTE paralogs and their splice variants are expressed in human prostate and encode proteins of different lengths. Bera TK, et al. Gene, 2004 Aug 4. PMID 15276201
    3. POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Bera TK, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12475935, Free PMC Article
    4. Analysis of the DNA sequence and duplication history of human chromosome 15. Zody MC, et al. Nature, 2006 Mar 30. PMID 16572171
    5. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identifies POTEB as being one of 30 genes with the most variable copy numbers in three human genomes.
      Title: Personalized copy number and segmental duplication maps using next-generation sequencing.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119373

    General protein information

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    Preferred Names
    POTE ankyrin domain family member B
    Names
    ANKRD26-like family B, member 1
    POTE ankyrin domain family member B2
    cancer/testis antigen family 104, member 5
    prostate, ovary, testis-expressed protein on chromosome 15
    protein expressed in prostate, ovary, testis, and placenta 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277304.2 → NP_001264233.1  POTE ankyrin domain family member B

      See identical proteins and their annotated locations for NP_001264233.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer variant and encodes the supported protein.
      Source sequence(s)
      AC183089
      Consensus CDS
      CCDS59250.1
      UniProtKB/Swiss-Prot
      A0A0A6YYL3, H3BUK9, Q495V7
      Related
      ENSP00000457689.2, ENST00000439682.2
      Conserved Domains (4) summary
      cd00204
      Location:130 → 255
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:201 → 232
      ANK; ANK repeat [structural motif]
      pfam14915
      Location:489 → 542
      CCDC144C; CCDC144C protein coiled-coil region
      cl25732
      Location:412 → 542
      SMC_N; RecF/RecN/SMC N terminal domain

    RNA

    1. NR_102391.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC183089
      Related
      ENST00000435397.6

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      21846329..21877735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017021858.2 → XP_016877347.1  POTE ankyrin domain family member B isoform X3

      UniProtKB/TrEMBL
      A0A0G2JQ08

    2. XM_047432072.1 → XP_047288028.1  POTE ankyrin domain family member B isoform X1

      UniProtKB/TrEMBL
      D7UEQ8

    3. XM_011543794.3 → XP_011542096.1  POTE ankyrin domain family member B isoform X2

      See identical proteins and their annotated locations for XP_011542096.1

      UniProtKB/TrEMBL
      A0A0G2JQ08
      Conserved Domains (4) summary
      cd00204
      Location:130 → 255
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:140 → 232
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:106 → 156
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:201 → 232
      ANK; ANK repeat [structural motif]

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160017.1 Reference GRCh38.p14 PATCHES

      Range
      3023460..3054807
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0A6YYL3.1 GenPept UniProtKB/Swiss-Prot:A0A0A6YYL3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials