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    PXK PX domain containing serine/threonine kinase like [ Homo sapiens (human) ]

    Gene ID: 54899, updated on 27-Nov-2024

    Summary

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    Official Symbol
    PXKprovided by HGNC
    Official Full Name
    PX domain containing serine/threonine kinase likeprovided by HGNC
    Primary source
    HGNC:HGNC:23326
    See related
    Ensembl:ENSG00000168297 MIM:611450; AllianceGenome:HGNC:23326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLOB; MONAKA
    Summary
    This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
    Expression
    Broad expression in thyroid (RPKM 17.1), brain (RPKM 11.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PXK in Genome Data Viewer
    Location:
    3p14.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (58332892..58426127)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (58373299..58466504)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (58318619..58411854)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58222930-58223869 Neighboring gene abhydrolase domain containing 6, acylglycerol lipase Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58276464-58277147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20008 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:58298051-58298552 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr3:58307710-58308471 Neighboring gene ribonuclease P/MRP subunit p14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14488 Neighboring gene Sharpr-MPRA regulatory region 6112 Neighboring gene hydroxyacyl-thioester dehydratase type 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20010 Neighboring gene uncharacterized LOC105377106 Neighboring gene MPRA-validated peak4672 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr3:58363583-58363810 Neighboring gene WDR53 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:58383233-58383732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20011 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20012 Neighboring gene uncharacterized LOC107986092 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14489 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:58420577-58421186 Neighboring gene pyruvate dehydrogenase E1 subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14490 Neighboring gene potassium channel tetramerization domain containing 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Polymorphisms of PXK are associated with autoantibody production, but not disease risk, of systemic lupus erythematosus in Chinese mainland population. Yu B, et al. Lupus, 2011 Jan. PMID 20829310
    2. Different genetic effect of PXK on systemic lupus erythematosus in the Korean population. Kim EM, et al. Rheumatol Int, 2012 Jan. PMID 21243490
    3. Expression pattern and subcellular localization of five splice isoforms of human PXK. Zou X, et al. Int J Mol Med, 2005 Oct. PMID 16142408
    4. PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6. Oparina NY, et al. Ann Rheum Dis, 2015 Mar. PMID 24534757
    5. Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis. Lee YH, et al. Inflamm Res, 2012 Sep. PMID 22592861

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Telomere Length and Male Fertility.
      Title: Telomere Length and Male Fertility.
    2. First described as part of human kinome analysis, named Slob after Drosophila ortholog.
      Title: The mouse kinome: discovery and comparative genomics of all mouse protein kinases.
    3. Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
      Title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
    4. genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L [rs2275247(A/G)] or JAZF1 [rs1635852(C/T)] are not associated.
      Title: Association between KIAA0319L, PXK and JAZF1 gene polymorphisms and unexplained recurrent pregnancy loss in Chinese Han couples.
    5. Results confirm the genetic association of the locus 3p14.3 with systemic lupus erythematosus in Europeans and point to the ABHD6 and not PXK, as the major susceptibility gene in the region.
      Title: PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6.
    6. study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
      Title: A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    7. The rs6445975 polymorphism of PXK and the rs2304256 polymorphism of tyrosine kinase 2 are associated with the development of systemic lupus erythematosus in Europeans
      Title: Associations between PXK and TYK2 polymorphisms and systemic lupus erythematosus: a meta-analysis.
    8. The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese.
      Title: Different genetic effect of PXK on systemic lupus erythematosus in the Korean population.
    9. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients.
    10. Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
      Title: Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus.
    Submit: New GeneRIF Correction See all GeneRIFs (17)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
    EBI GWAS Catalog
    Discovery and refinement of loci associated with lipid levels.
    EBI GWAS Catalog
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20335

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables ATP binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables nucleotide binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT enables protein kinase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in modulation of chemical synaptic transmission ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of ATP-dependent activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in negative regulation of monoatomic ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    NOT involved_in protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PX domain-containing protein kinase-like protein
    Names
    PX ser/thr kinase v2
    PX serine/threonine kinase
    modulator of Na,K-ATPase long form

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289095.2 → NP_001276024.1  PX domain-containing protein kinase-like protein isoform b

      See identical proteins and their annotated locations for NP_001276024.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and contains an alternate exon in the 3' coding region, compared to variant 1. This results in a frameshift and an early stop codon, compared to variant 1. It encodes isoform b (also known as isoform 2), which is shorter and has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK131385, AL137938, AY437879, DA296189
      Consensus CDS
      CCDS74954.1
      UniProtKB/TrEMBL
      A0A0C4DG95, B4DID9
      Related
      ENSP00000419049.1, ENST00000479241.5
      Conserved Domains (2) summary
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    2. NM_001289096.2 → NP_001276025.1  PX domain-containing protein kinase-like protein isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two consecutive, alternate, in-frame exons in the 5' coding region, compared to variant 1. It encodes isoform c (also known as isoform 3), which is shorter than isoform a.
      Source sequence(s)
      AL137938, AY274811, AY437879, BG613223, DA296189
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    3. NM_001289098.2 → NP_001276027.1  PX domain-containing protein kinase-like protein isoform d

      See identical proteins and their annotated locations for NP_001276027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform d (also known as isoform 4), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 4 and 8 both encode the same isoform (d).
      Source sequence(s)
      AK131385, AK296034, AL137938, DQ124708, HY164612
      Consensus CDS
      CCDS74952.1
      UniProtKB/TrEMBL
      B4DID9
      Related
      ENSP00000373222.4, ENST00000383716.7
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    4. NM_001289099.2 → NP_001276028.1  PX domain-containing protein kinase-like protein isoform e

      See identical proteins and their annotated locations for NP_001276028.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform e (also known as isoform 5), which has a shorter N-terminus, compared to isoform a. Variants 5 and 9 both encode the same isoform (e).
      Source sequence(s)
      AK131385, AL137938, AY847220, HY164612
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (3) summary
      cd22062
      Location:462 → 492
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    5. NM_001289100.2 → NP_001276029.1  PX domain-containing protein kinase-like protein isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two consecutive, alternate, in-frame exons in the 5' coding region and contains an alternate exon in the 3' region, resulting in an early stop codon, compared to variant 1. It encodes isoform f (also known as isoform 6), which is shorter and has a distinct C-terminus, compared to isoform a. Variants 6 and 10 both encode the same isoform (f).
      Source sequence(s)
      AK295542, AK296034, AL137938, AY274811, DA296189
      Consensus CDS
      CCDS74955.1
      UniProtKB/TrEMBL
      B4DID9, E9PD56
      Related
      ENSP00000417903.1, ENST00000463280.5
      Conserved Domains (3) summary
      COG0515
      Location:153 → 459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    6. NM_001289101.2 → NP_001276030.1  PX domain-containing protein kinase-like protein isoform g

      See identical proteins and their annotated locations for NP_001276030.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform g (also known as isoform 7), which is shorter at the N-terminus, compared to isoform a. Variants 7 and 11 both encode the same isoform (g).
      Source sequence(s)
      AK131385, AK296215, AL137938, AY274811, DA296189
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:408 → 438
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61 → 208
      PKc_like; Protein Kinases, catalytic domain

    7. NM_001349488.2 → NP_001336417.1  PX domain-containing protein kinase-like protein isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8), as well as variant 4, encodes isoform d.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS74952.1
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    8. NM_001349489.2 → NP_001336418.1  PX domain-containing protein kinase-like protein isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 5, encodes isoform e.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (3) summary
      cd22062
      Location:462 → 492
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl21453
      Location:115 → 262
      PKc_like; Protein Kinases, catalytic domain

    9. NM_001349490.2 → NP_001336419.1  PX domain-containing protein kinase-like protein isoform f

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 6, encodes isoform f.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS74955.1
      UniProtKB/TrEMBL
      B4DID9, E9PD56
      Conserved Domains (3) summary
      COG0515
      Location:153 → 459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    10. NM_001349491.2 → NP_001336420.1  PX domain-containing protein kinase-like protein isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (11), as well as variant 7, encodes isoform g.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:408 → 438
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61 → 208
      PKc_like; Protein Kinases, catalytic domain

    11. NM_001349492.2 → NP_001336421.1  PX domain-containing protein kinase-like protein isoform h

      Status: VALIDATED

      Description
      Transcript Variant: This variant (12) encodes the longest isoform (h).
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    12. NM_001349493.2 → NP_001336422.1  PX domain-containing protein kinase-like protein isoform i

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13) encodes isoform i.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cl21453
      Location:198 → 345
      PKc_like; Protein Kinases, catalytic domain

    13. NM_001349494.2 → NP_001336423.1  PX domain-containing protein kinase-like protein isoform j

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14) encodes isoform j.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:529 → 559
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:182 → 329
      PKc_like; Protein Kinases, catalytic domain

    14. NM_001349495.2 → NP_001336424.1  PX domain-containing protein kinase-like protein isoform k

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15) encodes isoform k.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:528 → 558
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:182 → 329
      PKc_like; Protein Kinases, catalytic domain

    15. NM_001349496.2 → NP_001336425.1  PX domain-containing protein kinase-like protein isoform jj

      Status: VALIDATED

      Description
      Transcript Variant: This variant (16) encodes isoform jj.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      COG0515
      Location:169 → 475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    16. NM_001349497.2 → NP_001336426.1  PX domain-containing protein kinase-like protein isoform l

      Status: VALIDATED

      Description
      Transcript Variant: This variant (17) encodes isoform l.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    17. NM_001349498.1 → NP_001336427.1  PX domain-containing protein kinase-like protein isoform m

      Status: VALIDATED

      Description
      Transcript Variant: This variant (18) encodes isoform m.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      W5RWD6
      Conserved Domains (3) summary
      cd06871
      Location:15 → 112
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:166 → 472
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:178 → 325
      PKc; Catalytic domain of Protein Kinases

    18. NM_001349499.2 → NP_001336428.1  PX domain-containing protein kinase-like protein isoform n

      Status: VALIDATED

      Description
      Transcript Variant: This variant (19) encodes isoform n.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS87097.1
      UniProtKB/TrEMBL
      W5RWE6
      Related
      ENSP00000305045.6, ENST00000302779.9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 526
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    19. NM_001349500.2 → NP_001336429.1  PX domain-containing protein kinase-like protein isoform o

      Status: VALIDATED

      Description
      Transcript Variant: This variant (20) encodes isoform o.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    20. NM_001349501.2 → NP_001336430.1  PX domain-containing protein kinase-like protein isoform p

      Status: VALIDATED

      Description
      Transcript Variant: This variant (21) encodes isoform p.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170 → 510
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182 → 329
      PKc; Catalytic domain of Protein Kinases

    21. NM_001349502.2 → NP_001336431.1  PX domain-containing protein kinase-like protein isoform q

      Status: VALIDATED

      Description
      Transcript Variant: This variant (22) encodes isoform q.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (3) summary
      COG0515
      Location:169 → 509
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    22. NM_001349503.2 → NP_001336432.1  PX domain-containing protein kinase-like protein isoform r

      Status: VALIDATED

      Description
      Transcript Variant: This variant (23), as well as variant 26, encodes isoform r.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    23. NM_001349504.2 → NP_001336433.1  PX domain-containing protein kinase-like protein isoform kk

      Status: VALIDATED

      Description
      Transcript Variant: This variant (24), as well as variant 25, encodes isoform kk.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    24. NM_001349506.2 → NP_001336435.1  PX domain-containing protein kinase-like protein isoform kk

      Status: VALIDATED

      Description
      Transcript Variant: This variant (25), as well as variant 24, encodes isoform kk.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    25. NM_001349507.2 → NP_001336436.1  PX domain-containing protein kinase-like protein isoform r

      Status: VALIDATED

      Description
      Transcript Variant: This variant (26), as well as variant 23, encodes isoform r.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    26. NM_001349508.2 → NP_001336437.1  PX domain-containing protein kinase-like protein isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (27), as well as variant 28, encodes isoform s.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    27. NM_001349509.2 → NP_001336438.1  PX domain-containing protein kinase-like protein isoform s

      Status: VALIDATED

      Description
      Transcript Variant: This variant (28), as well as variant 27, encodes isoform s.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    28. NM_001349510.2 → NP_001336439.1  PX domain-containing protein kinase-like protein isoform t

      Status: VALIDATED

      Description
      Transcript Variant: This variant (29) encodes isoform t.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170 → 476
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182 → 329
      PKc; Catalytic domain of Protein Kinases

    29. NM_001349511.2 → NP_001336440.1  PX domain-containing protein kinase-like protein isoform u

      Status: VALIDATED

      Description
      Transcript Variant: This variant (30) encodes isoform u.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:182 → 329
      PKc; Catalytic domain of Protein Kinases

    30. NM_001349512.2 → NP_001336441.1  PX domain-containing protein kinase-like protein isoform ll

      Status: VALIDATED

      Description
      Transcript Variant: This variant (31) encodes isoform ll.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:170 → 476
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:182 → 329
      PKc; Catalytic domain of Protein Kinases

    31. NM_001349513.2 → NP_001336442.1  PX domain-containing protein kinase-like protein isoform mm

      Status: VALIDATED

      Description
      Transcript Variant: This variant (32) encodes isoform mm.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103 → 409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    32. NM_001349514.2 → NP_001336443.1  PX domain-containing protein kinase-like protein isoform nn

      Status: VALIDATED

      Description
      Transcript Variant: This variant (33) encodes isoform nn.
      Source sequence(s)
      AC098479, AC135507
      Consensus CDS
      CCDS87098.1
      UniProtKB/TrEMBL
      B4DID9, H7BYG4
      Related
      ENSP00000373221.4, ENST00000383715.8
      Conserved Domains (3) summary
      COG0515
      Location:169 → 475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    33. NM_001349515.2 → NP_001336444.1  PX domain-containing protein kinase-like protein isoform v

      Status: VALIDATED

      Description
      Transcript Variant: This variant (34) encodes isoform v.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    34. NM_001349516.2 → NP_001336445.1  PX domain-containing protein kinase-like protein isoform oo

      Status: VALIDATED

      Description
      Transcript Variant: This variant (35) encodes isoform oo.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd06871
      Location:13 → 116
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd00180
      Location:182 → 329
      PKc; Catalytic domain of Protein Kinases

    35. NM_001349517.2 → NP_001336446.1  PX domain-containing protein kinase-like protein isoform pp

      Status: VALIDATED

      Description
      Transcript Variant: This variant (36) encodes isoform pp.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:169 → 475
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    36. NM_001349518.2 → NP_001336447.1  PX domain-containing protein kinase-like protein isoform w

      Status: VALIDATED

      Description
      Transcript Variant: This variant (37) encodes isoform w.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:181 → 328
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 115
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    37. NM_001349519.2 → NP_001336448.1  PX domain-containing protein kinase-like protein isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (38), as well as variant 39, encodes isoform x.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 493
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    38. NM_001349520.2 → NP_001336449.1  PX domain-containing protein kinase-like protein isoform x

      Status: VALIDATED

      Description
      Transcript Variant: This variant (39), as well as variant 38, encodes isoform x.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 493
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    39. NM_001349521.2 → NP_001336450.1  PX domain-containing protein kinase-like protein isoform qq

      Status: VALIDATED

      Description
      Transcript Variant: This variant (40) encodes isoform qq.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    40. NM_001349522.2 → NP_001336451.1  PX domain-containing protein kinase-like protein isoform y

      Status: VALIDATED

      Description
      Transcript Variant: This variant (41) encodes isoform y.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:153 → 459
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    41. NM_001349524.2 → NP_001336453.1  PX domain-containing protein kinase-like protein isoform z

      Status: VALIDATED

      Description
      Transcript Variant: This variant (42) encodes isoform z.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:165 → 312
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:13 → 99
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    42. NM_001349525.2 → NP_001336454.1  PX domain-containing protein kinase-like protein isoform aa

      Status: VALIDATED

      Description
      Transcript Variant: This variant (43) encodes isoform aa.
      Source sequence(s)
      AC098479, AC135507
      Conserved Domains (2) summary
      COG0515
      Location:49 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    43. NM_001349526.2 → NP_001336455.1  PX domain-containing protein kinase-like protein isoform bb

      Status: VALIDATED

      Description
      Transcript Variant: This variant (44) encodes isoform bb.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      cd22062
      Location:407 → 437
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:61 → 208
      PKc_like; Protein Kinases, catalytic domain

    44. NM_001349527.2 → NP_001336456.1  PX domain-containing protein kinase-like protein isoform cc

      Status: VALIDATED

      Description
      Transcript Variant: This variant (45) encodes isoform cc.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      COG0515
      Location:186 → 492
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:198 → 345
      PKc; Catalytic domain of Protein Kinases

    45. NM_001349528.2 → NP_001336457.1  PX domain-containing protein kinase-like protein isoform dd

      Status: VALIDATED

      Description
      Transcript Variant: This variant (46), as well as variant 47, encodes isoform dd.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103 → 409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    46. NM_001349529.2 → NP_001336458.1  PX domain-containing protein kinase-like protein isoform dd

      Status: VALIDATED

      Description
      Transcript Variant: This variant (47), as well as variant 46, encodes isoform dd.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103 → 409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    47. NM_001349530.2 → NP_001336459.1  PX domain-containing protein kinase-like protein isoform ee

      Status: VALIDATED

      Description
      Transcript Variant: This variant (48) encodes isoform ee.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (2) summary
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    48. NM_001349531.2 → NP_001336460.1  PX domain-containing protein kinase-like protein isoform rr

      Status: VALIDATED

      Description
      Transcript Variant: This variant (49) encodes isoform rr.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DID9
      Conserved Domains (3) summary
      COG0515
      Location:103 → 409
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:115 → 262
      PKc; Catalytic domain of Protein Kinases
      cl02563
      Location:1 → 49
      PX_domain; The Phox Homology domain, a phosphoinositide binding module

    49. NM_001349532.2 → NP_001336461.1  PX domain-containing protein kinase-like protein isoform ff

      Status: VALIDATED

      Description
      Transcript Variant: This variant (50) encodes isoform ff.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJS8
      Conserved Domains (2) summary
      COG0515
      Location:49 → 389
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    50. NM_001349533.2 → NP_001336462.1  PX domain-containing protein kinase-like protein isoform gg

      Status: VALIDATED

      Description
      Transcript Variant: This variant (51), as well as variant 52, encodes isoform gg.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    51. NM_001349534.2 → NP_001336463.1  PX domain-containing protein kinase-like protein isoform gg

      Status: VALIDATED

      Description
      Transcript Variant: This variant (52), as well as variant 51, encodes isoform gg.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    52. NM_001349535.2 → NP_001336464.1  PX domain-containing protein kinase-like protein isoform hh

      Status: VALIDATED

      Description
      Transcript Variant: This variant (53), as well as variant 54, encodes isoform hh.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    53. NM_001349536.2 → NP_001336465.1  PX domain-containing protein kinase-like protein isoform hh

      Status: VALIDATED

      Description
      Transcript Variant: This variant (54), as well as variant 53, encodes isoform hh.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (2) summary
      COG0515
      Location:49 → 355
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    54. NM_001349537.2 → NP_001336466.1  PX domain-containing protein kinase-like protein isoform ss

      Status: VALIDATED

      Description
      Transcript Variant: This variant (55), as well as variant 56, encodes isoform ss.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    55. NM_001349538.2 → NP_001336467.1  PX domain-containing protein kinase-like protein isoform ss

      Status: VALIDATED

      Description
      Transcript Variant: This variant (56), as well as variant 55, encodes isoform ss.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    56. NM_001349539.2 → NP_001336468.1  PX domain-containing protein kinase-like protein isoform ii

      Status: VALIDATED

      Description
      Transcript Variant: This variant (57), as well as variant 58, encodes isoform ii.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    57. NM_001349540.2 → NP_001336469.1  PX domain-containing protein kinase-like protein isoform ii

      Status: VALIDATED

      Description
      Transcript Variant: This variant (58), as well as variant 57, encodes isoform ii.
      Source sequence(s)
      AC098479, AC135507
      UniProtKB/TrEMBL
      B4DJD8
      Conserved Domains (1) summary
      cd00180
      Location:61 → 208
      PKc; Catalytic domain of Protein Kinases

    58. NM_017771.5 → NP_060241.2  PX domain-containing protein kinase-like protein isoform a

      See identical proteins and their annotated locations for NP_060241.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a (also known as isoform 1).
      Source sequence(s)
      AK296034, AL137938, AY274811, DQ124707, DQ124708, HY164612
      Consensus CDS
      CCDS2889.1
      UniProtKB/Swiss-Prot
      Q3BCH4, Q3BCH5, Q3BCH6, Q3BDW1, Q45L83, Q59EX3, Q6PK17, Q6ZN39, Q7Z7A4, Q96CA3, Q96R07, Q9NXB8
      Related
      ENSP00000348472.2, ENST00000356151.7
      Conserved Domains (3) summary
      cd06871
      Location:13 → 132
      PX_MONaKA; The phosphoinositide binding Phox Homology domain of Modulator of Na,K-ATPase
      cd22062
      Location:545 → 575
      WH2_DdVASP-like; Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Dictyostelium discoideum Vasodilator-stimulated phosphoprotein (VASP) and similar proteins
      cl21453
      Location:198 → 345
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. NR_146193.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098479, AC135507

    2. NR_146194.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC098479, AC135507

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      58332892..58426127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      58373299..58466504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z7A4.1 GenPept UniProtKB/Swiss-Prot:Q7Z7A4

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