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    IQCG IQ motif containing G [ Homo sapiens (human) ]

    Gene ID: 84223, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IQCGprovided by HGNC
    Official Full Name
    IQ motif containing Gprovided by HGNC
    Primary source
    HGNC:HGNC:25251
    See related
    Ensembl:ENSG00000114473 MIM:612477; AllianceGenome:HGNC:25251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRC9; CFAP122
    Summary
    Enables Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 19.6), ovary (RPKM 6.1) and 20 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IQCG in Genome Data Viewer
    Location:
    3q29
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (197889077..197960177, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (200621536..200692632, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (197615948..197686862, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC124909482 Neighboring gene uncharacterized LOC105374310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21121 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:197581553-197582752 Neighboring gene ribosomal protein L17 pseudogene 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197594026-197594561 Neighboring gene NUP98-IQCG recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197626412-197627184 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:197628168-197628668 Neighboring gene RNA, U6 small nuclear 858, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15094 Neighboring gene uncharacterized LOC124906330 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:197639502-197640701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197676763-197677545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197678329-197679110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:197685865-197686365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15095 Neighboring gene MPRA-validated peak4998 silencer Neighboring gene ribosomal protein L35a Neighboring gene MPRA-validated peak4999 silencer Neighboring gene leishmanolysin like peptidase Neighboring gene RNA, U6 small nuclear 621, pseudogene Neighboring gene LMLN antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway. Pan MM, et al. Leukemia, 2016 Jul. PMID 26675333
    2. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. Harris TP, et al. G3 (Bethesda), 2014 Feb 19. PMID 24362311, Free PMC Article
    3. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. Bower R, et al. Mol Biol Cell, 2013 Apr. PMID 23427265, Free PMC Article
    4. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Chen LT, et al. Nat Commun, 2014 May 2. PMID 24787902
    5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. human NUP98-IQCG fusion protein could induce fatal and transplantable acute myelomonocytic leukemia in a mouse model
      Title: Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ11667, FLJ23571, FLJ37775, DKFZp434B227

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calmodulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in spermatid development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in manchette ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in sperm flagellum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in sperm flagellum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein regulatory complex protein 9
    Names
    IQ domain-containing protein G
    dynein regulatory complex subunit 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033072.1 RefSeqGene

      Range
      5025..75939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134435.3 → NP_001127907.1  dynein regulatory complex protein 9 isoform a

      See identical proteins and their annotated locations for NP_001127907.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 3 encode the same isoform (a).
      Source sequence(s)
      AK027224, CR533515, DA566107
      Consensus CDS
      CCDS3331.1
      UniProtKB/Swiss-Prot
      Q9BST2, Q9H095, Q9HAG8
      UniProtKB/TrEMBL
      B9EG57
      Related
      ENSP00000407736.1, ENST00000455191.5
      Conserved Domains (2) summary
      smart00015
      Location:393 → 412
      IQ; Calmodulin-binding motif
      TIGR02169
      Location:179 → 396
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_001323027.2 → NP_001309956.1  dynein regulatory complex protein 9 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 3 encode the same isoform (a).
      Source sequence(s)
      AC135893, BC004816
      Consensus CDS
      CCDS3331.1
      UniProtKB/Swiss-Prot
      Q9BST2, Q9H095, Q9HAG8
      UniProtKB/TrEMBL
      B9EG57
      Conserved Domains (2) summary
      smart00015
      Location:393 → 412
      IQ; Calmodulin-binding motif
      TIGR02169
      Location:179 → 396
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. NM_001323028.2 → NP_001309957.1  dynein regulatory complex protein 9 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC135893, BC004816
      UniProtKB/TrEMBL
      B9EG57
      Conserved Domains (2) summary
      PTZ00108
      Location:312 → 381
      PTZ00108; DNA topoisomerase 2-like protein; Provisional
      pfam04111
      Location:204 → 345
      APG6; Autophagy protein Apg6

    4. NM_001323029.2 → NP_001309958.1  dynein regulatory complex protein 9 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC135893, BC004816
      UniProtKB/Swiss-Prot
      Q9H095
      Conserved Domains (1) summary
      TIGR02169
      Location:81 → 298
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    5. NM_001323030.2 → NP_001309959.1  dynein regulatory complex protein 9 isoform d

      Status: VALIDATED

      Source sequence(s)
      BC068973, DA566107
      Consensus CDS
      CCDS82898.1
      UniProtKB/TrEMBL
      C9JKX8
      Related
      ENSP00000389897.1, ENST00000453254.5

    6. NM_032263.5 → NP_115639.1  dynein regulatory complex protein 9 isoform a

      See identical proteins and their annotated locations for NP_115639.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1 through 3 encode the same isoform (a).
      Source sequence(s)
      AL136889, BC004816, BC016156, CK001737
      Consensus CDS
      CCDS3331.1
      UniProtKB/Swiss-Prot
      Q9BST2, Q9H095, Q9HAG8
      UniProtKB/TrEMBL
      B9EG57
      Related
      ENSP00000265239.6, ENST00000265239.11
      Conserved Domains (2) summary
      smart00015
      Location:393 → 412
      IQ; Calmodulin-binding motif
      TIGR02169
      Location:179 → 396
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      197889077..197960177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453790.2 → XP_024309558.1  dynein regulatory complex protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q9BST2, Q9H095, Q9HAG8
      UniProtKB/TrEMBL
      B9EG57
      Conserved Domains (2) summary
      smart00015
      Location:393 → 412
      IQ; Calmodulin-binding motif
      TIGR02169
      Location:179 → 396
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RNA

    1. XR_007095755.1 RNA Sequence

    2. XR_007095756.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      200621536..200692632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348086.1 → XP_054204061.1  dynein regulatory complex protein 9 isoform X1

      UniProtKB/Swiss-Prot
      Q9BST2, Q9H095, Q9HAG8
      UniProtKB/TrEMBL
      B9EG57

    RNA

    1. XR_008486840.1 RNA Sequence

    2. XR_008486841.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H095.1 GenPept UniProtKB/Swiss-Prot:Q9H095

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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