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    FASTKD3 FAST kinase domains 3 [ Homo sapiens (human) ]

    Gene ID: 79072, updated on 9-Dec-2024

    Summary

    Official Symbol
    FASTKD3provided by HGNC
    Official Full Name
    FAST kinase domains 3provided by HGNC
    Primary source
    HGNC:HGNC:28758
    See related
    Ensembl:ENSG00000124279 MIM:617530; AllianceGenome:HGNC:28758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene encodes a member of a small family of Fas-activated serine/threonine kinase domain (FASTKD) containing proteins that share an amino terminal mitochondrial targeting domain and multiple carboxy terminal FAST domains as well as a putative RNA-binding RAP domain. The members of this family are ubiquitously expressed and are generally most abundant in mitochondria-enriched tissues such as heart, skeletal muscle and brown-adipose tissue. Some members of this protein family may play a role in apoptosis. The protein encoded by this gene interacts with components of the mitochondrial respiratory and translation networks. A pseudogene of this gene is also present on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
    Expression
    Ubiquitous expression in kidney (RPKM 3.9), lymph node (RPKM 3.8) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See FASTKD3 in Genome Data Viewer
    Location:
    5p15.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (7859159..7869031, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (7798283..7808155, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (7859272..7869144, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374646 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7420020-7420743 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7420744-7421468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:7422307-7423176 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7424665-7425194 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7425195-7425722 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:7427184-7427875 Neighboring gene adenylate cyclase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:7480982-7481482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:7481483-7481983 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:7515349-7515849 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:7526205-7526704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7596934-7597448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7597449-7597963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:7663263-7663836 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:7663837-7664409 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:7667125-7668324 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:7683613-7683799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22346 Neighboring gene Sharpr-MPRA regulatory region 1766 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7815313-7815850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7816087-7816815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:7816816-7817543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15904 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15905 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15906 Neighboring gene cilia and flagella associated protein 90 Neighboring gene uncharacterized LOC124900936 Neighboring gene 5-methyltetrahydrofolate-homocysteine methyltransferase reductase Neighboring gene semaphorin 5A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC5297, FLJ23274, MGC142123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion HTP PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    FAST kinase domain-containing protein 3, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033101.1 RefSeqGene

      Range
      5007..14879
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_024091.4NP_076996.2  FAST kinase domain-containing protein 3, mitochondrial

      See identical proteins and their annotated locations for NP_076996.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longest transcript and encodes the protein.
      Source sequence(s)
      AK026927, BC001295, BP317791, BQ921348, DA297400
      Consensus CDS
      CCDS3873.1
      UniProtKB/Swiss-Prot
      Q14CZ7, Q9BVD3
      Related
      ENSP00000264669.5, ENST00000264669.10
      Conserved Domains (3) summary
      smart00952
      Location:593650
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:409477
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:493579
      FAST_2; FAST kinase-like protein, subdomain 2

    RNA

    1. NR_036553.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) omits the first coding exon, compared to variant 1. The transcript is predicted to be non-coding because the next available AUG does not appear to be in a favorable context and would result in a severely N-terminally truncated protein. Therefore a coding sequence is not annotated.
      Source sequence(s)
      AF161354, AK026927, BC001295, DA297400
    2. NR_073608.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) omits the first coding exon and uses an alternate splice site in a downstream exon, compared to variant 1. The transcript is predicted to be non-coding because the next available AUG does not appear to be in a favorable context and would result in a severely N-terminally truncated protein. Therefore a coding sequence is not annotated.
      Source sequence(s)
      BC001295, BG613096, DA297400
      Related
      ENST00000513658.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      7859159..7869031 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006714498.2XP_006714561.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006714561.1

      UniProtKB/Swiss-Prot
      Q14CZ7, Q9BVD3
      Conserved Domains (3) summary
      smart00952
      Location:593650
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:409477
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:493579
      FAST_2; FAST kinase-like protein, subdomain 2
    2. XM_047417699.1XP_047273655.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q14CZ7, Q9BVD3
    3. XM_047417700.1XP_047273656.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D6RAR6
      Related
      ENSP00000421798.1, ENST00000507036.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      7798283..7808155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054353439.1XP_054209414.1  FAST kinase domain-containing protein 3, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      Q14CZ7, Q9BVD3
    2. XM_054353440.1XP_054209415.1  FAST kinase domain-containing protein 3, mitochondrial isoform X2

      UniProtKB/TrEMBL
      D6RAR6