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    SF3B5 splicing factor 3b subunit 5 [ Homo sapiens (human) ]

    Gene ID: 83443, updated on 10-Dec-2024

    Summary

    Official Symbol
    SF3B5provided by HGNC
    Official Full Name
    splicing factor 3b subunit 5provided by HGNC
    Primary source
    HGNC:HGNC:21083
    See related
    Ensembl:ENSG00000169976 MIM:617847; AllianceGenome:HGNC:21083
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Ysf3; SF3b10
    Summary
    Enables RNA binding activity and splicing factor binding activity. Involved in mRNA splicing, via spliceosome. Located in nucleoplasm. Part of U12-type spliceosomal complex and U2-type precatalytic spliceosome. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
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    Genomic context

    See SF3B5 in Genome Data Viewer
    Location:
    6q24.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (144094884..144095573, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (145287613..145288302, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144416021..144416710, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene PLAG1 like zinc finger 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:144328825-144329007 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17632 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17633 Neighboring gene hydatidiform mole associated and imprinted Neighboring gene FKBP prolyl isomerase 7 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17635 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17637 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:144410739-144410950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25211 Neighboring gene uncharacterized LOC105378036 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 3

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3133

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables splicing factor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of SAGA complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U12-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of U2 snRNP NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of U2-type precatalytic spliceosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of U2-type spliceosomal complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of spliceosomal complex NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    splicing factor 3B subunit 5
    Names
    pre-mRNA-splicing factor SF3b 10 kDa subunit
    splicing factor 3b, subunit 5, 10kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031287.3NP_112577.1  splicing factor 3B subunit 5

      See identical proteins and their annotated locations for NP_112577.1

      Status: VALIDATED

      Source sequence(s)
      AK074417
      Consensus CDS
      CCDS5204.1
      UniProtKB/Swiss-Prot
      B2R568, Q7RTV1, Q9BWJ5
      Related
      ENSP00000356541.2, ENST00000367569.4
      Conserved Domains (1) summary
      pfam07189
      Location:377
      SF3b10; Splicing factor 3B subunit 10 (SF3b10)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      144094884..144095573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      145287613..145288302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)