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    MIRLET7BHG MIRLET7B host gene [ Homo sapiens (human) ]

    Gene ID: 400931, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIRLET7BHGprovided by HGNC
    Official Full Name
    MIRLET7B host geneprovided by HGNC
    Primary source
    HGNC:HGNC:37189
    See related
    Ensembl:ENSG00000197182 MIM:618216; AllianceGenome:HGNC:37189
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRR34-AS1; linc-Ppara
    Summary
    Predicted to be involved in miRNA-mediated post-transcriptional gene silencing. Predicted to be part of RISC complex. Implicated in lung cancer. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in skin (RPKM 5.0), placenta (RPKM 2.2) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MIRLET7BHG in Genome Data Viewer
    Location:
    22q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (46085997..46113928)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (46570566..46598616)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (46481877..46509808)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene collagen alpha-1(III) chain-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19231 Neighboring gene PRR34 antisense RNA 1 Neighboring gene PRR34 long non-coding RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13898 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13900 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46467816-46468370 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46468371-46468923 Neighboring gene long intergenic non-protein coding RNA 2939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46480369-46480940 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:46481213-46482412 Neighboring gene uncharacterized LOC112268288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46483852-46484461 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:46500537-46501051 Neighboring gene microRNA 3619 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46506657-46507190 Neighboring gene microRNA let-7a-3 Neighboring gene microRNA let-7b Neighboring gene microRNA 4763 Neighboring gene uncharacterized LOC124905137 Neighboring gene uncharacterized LOC124905138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:46533901-46534402 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13903 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19232 Neighboring gene uncharacterized LOC105373074 Neighboring gene peroxisome proliferator activated receptor alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic sequestration of HDAC7 from mitochondrial and nuclear compartments upon initiation of apoptosis. Bakin RE, et al. J Biol Chem, 2004 Dec 3. PMID 15364908
    2. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. Sauvageau M, et al. Elife, 2013 Dec 31. PMID 24381249, Free PMC Article
    3. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article
    4. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. Choudhury NR, et al. BMC Biol, 2017 Nov 8. PMID 29117863, Free PMC Article
    5. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • MIRLET7B host gene (non-protein coding)
    • PRR34 antisense RNA 1

    Clone Names

    • FLJ27365

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in miRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RISC complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_027033.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AK023424, AK130875, FP325332

    2. NR_110479.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate internal exon and uses an alternate splice site at the 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK023424, AK130875, FP325332
      Related
      ENST00000360737.4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      46085997..46113928
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      46570566..46598616
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_207477.1: Suppressed sequence

      Description
      NM_207477.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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